Implantable sensor employing an auxiliary electrode

• US 5,914,026 A
• Filed: 01/06/1997
• Issued: 06/22/1999
• Est. Priority Date: 01/06/1997
• Status: Expired due to Term

• Current Assignee: Tenax Therapeutics, Inc.
• Original Assignee: Implanted Biosystems Incorporated
• Inventors: Houser, Kevin L., Brunsman, Alan R., Blubaugh, Elmo A. Jr.
• Primary Examiner(s): Beisner, William H.
• Assistant Examiner(s): Noguerda, Alex
• Application Number:
  US08/779,304
• Time in Patent Office: 897 Days
• Field of Search: 604/20, 604/891.1, 204/403, 205/777.5, 205/779, 205/792, 606/41, 606/34, 606/32, 435/817, 435/180, 435/287.9
• US Class Current: 600/347
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: Y10S 435/817 Enzyme or microbe electrode

Abstract

An implantable sensor comprising a biocompatible electroconductive case which houses a measuring electrode, a reference electrode, an auxiliary electrode, and an electronic circuit for measuring the response of the measuring electrode where the measuring electrode, reference electrode and auxiliary electrode are not in direct electrical contact with one another is provided. The implantable sensor of the present invention is particularly useful as a glucose sensor, especially when an enzyme-containing membrane is included in the measuring electrode.

Claims

1. A sensor for implanting in the body of a patient comprising a biocompatible electroconductive case, a voltage source, a measuring electrode, and a reference electrode;

the case, the voltage source, the measuring electrode and the reference electrode being associated in an electrical circuit in which the case functions as an auxiliary electrode, wherein the measuring electrode includes an enzyme-containing membrane having a semi-interpenetrating polymer network of fibrillated polytetrafluoroethylene and a silicon compound, wherein the network is infiltrated with an enzyme.

2. The sensor of claim 1 wherein said measuring electrode is a platinum anode.

3. The sensor of claim 2 wherein said reference electrode is a silver electrode.

4. The sensor of claim 2 wherein said reference electrode is a silver/silver chloride electrode.

5. The sensor of claim 2 wherein said case is titanium.

6. The sensor of claim 5 wherein the electronic circuit includes a potentiostat for sensing the potential difference between the reference electrode and the measuring electrode.

7. The sensor of claim 5 wherein the case includes a first port containing the reference electrode and a second port containing the measuring electrode.

8. The sensor of claim 5 wherein the electrical circuit further includes means for transmitting a signal to a receiver located outside the body.

9. The sensor of claim 5 wherein the case includes a port containing the reference electrode and the measuring electrode.

10. The sensor of claim 1 wherein the measuring electrode, the reference electrode and the case, when in contact with an ionically conductive solution complete an electric circuit.

11. A method for detecting the glucose level in a patient comprising:

implanting a glucose sensor including biocompatible electroconductive case, a voltage source, a measuring electrode, and a reference electrode;

the case, voltage source, measuring electrode and reference electrode being associated in an electrical circuit in which the case function as an auxiliary electrode, wherein the measuring electrode includes an enzyme-containing membrane having a semi-interpenetrating polymer network of fibrillated polytetrafluoroethylene and a silicon compound, wherein the network is infiltrated with an enzyme.

12. The method of claim 11 wherein the measuring electrode is a platinum anode.

13. The method claim 12 wherein the reference electrode is a silver electrode.

14. The method claim 13 wherein said reference electrode is a silver/silver chloride electrode.

15. The method claim 13 wherein the case is titanium.

16. The method of claim 15 wherein the electronic circuit includes a potentiostat for sensing the potential difference between the reference electrode and the measuring electrode.

17. The method of claim 16 wherein the case includes a first port containing the reference electrode and a second port containing the measuring electrode.

18. The method of claim 16 wherein the electronic circuit further includes means for transmitting a signal to receive located outside the body.

19. The method of claim 16 wherein the case includes a port containing the reference electrode and the measuring electrode.