Method of enhancing performance in pulse oximetry via electrical stimulation

• US 5,916,154 A
• Filed: 04/22/1998
• Issued: 06/29/1999
• Est. Priority Date: 04/22/1998
• Status: Expired due to Term

• Current Assignee: NELLCOR PURITAN BENNETT
• Original Assignee: NELLCOR PURITAN BENNETT
• Inventors: Hobbs, Steven E., Flewelling, Ross
• Primary Examiner(s): O'Connor, Cary
• Assistant Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US09/064,639
• Time in Patent Office: 433 Days
• Field of Search: 600/310, 600/322, 600/323, 600/334, 600/335, 600/473, 600/476
• US Class Current: 600/334
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61N 1/326 for promoting growth of cells, e.g. bone cells

Abstract

An improved method for optically measuring a characteristic of a patient'"'"'s blood or tissue is provided which involves first passing an arterialization current (typically from about 1-10 mA AC or DC) through a relatively short tissue segment of a patient (up to about 12 inches) for a period of time sufficient to significantly increase blood flow, whereupon a transcutaneous optical measurement is made. The method is especially suited for pulse oximetry and permits more accurate readings owing to the increased amplitude of the detection signal. In another embodiment, a probe molecule composition may be initially applied to the patient'"'"'s skin, and the arterialization current is used to rapidly and evenly diffuse the probe molecule into the tissue segment. An appropriate sensor can then be employed for detecting the probe molecule.

Claims

1. A method of optically measuring a characteristic of a patient'"'"'s blood or tissue comprising the steps of:

(a) passing a current through a tissue segment of a patient, the tissue segment having blood flow therethrough, including the steps of placing a pair of electrodes on the patient'"'"'s skin at a distance apart of up to about twelve inches, and passing the current through the electrodes and the tissue segment therebetween in order to increase the blood flow through the tissue segment without the use of chemical irritants or perfusion enhancing solutions;

(b) transmitting light into a test site in the tissue segment during the time of the increased blood flow; and

(c) detecting light adjacent the test site as a parameter indicative of the characteristic to be measured.

2. The method of claim 1, said characteristic to be measured being the amount of arterial blood oxygen.

3. The method of claim 1, wherein the current is from about 1 mA to about 10 mA.

4. The method of claim 1, wherein the steps of transmitting and detecting are performed with a pulse oximeter.

5. The method of claim 4, further including the step of varying the current to maintain an enhanced signal from the pulse oximeter.

6. The method of claim 1, wherein the current is applied for about 1 minute to about 30 minutes.

7. The method of claim 1, further including the steps of applying a composition containing a probe molecule to a portion of the patient'"'"'s skin adjacent said tissue segment prior to said current passing step, and causing said probe molecule to be transmitted through the patient'"'"'s skin by said passage of current.

8. The method of claim 7, said probe molecule being selected from the group consisting of pH fluorescent probes, pH absorbance probes, fluorescent Ca²⁺ probes and fluorescent oxygen probes.

9. The method of claim 1, wherein said characteristic to be measured is the amount of a selected gas in the patient'"'"'s blood.

10. The method of claim 9, wherein the gas is selected from the group consisting of oxygen and carbon dioxide.

11. The method of claim 1, wherein said characteristics to be measured is the amount of an electrolyte in the patient'"'"'s blood.

12. The method of claim 11, wherein the electrolyte is selected from the group consisting of Na⁺, Ca²⁺, and K⁺.

13. The method of claim 1, wherein said characteristics to be measured is tissue oxygen pressure.

14. The method of claim 1, wherein said characteristic to be measured is pH.

15. The method of claim 1, one of said electrodes including a pad and further including the steps of applying a probe molecule to said electrode pad prior to said current passing step, and causing said probe molecule to be transmitted through the patient'"'"'s skin by said passage of current.

16. The method of claim 15, said molecule being selected from the group consisting of pH fluorescent probes, pH absorbance probes, fluorescent Ca²⁺ probes and fluorescent oxygen probes.