Tissue monitor

• US 5,916,171 A
• Filed: 05/27/1997
• Issued: 06/29/1999
• Est. Priority Date: 05/31/1994
• Status: Expired due to Fees

• Current Assignee: Vital Media
• Original Assignee: Vital Media
• Inventors: Mayevsky, Avraham
• Primary Examiner(s): Casler, Brian L.
• Application Number:
  US08/863,928
• Time in Patent Office: 763 Days
• Field of Search: 600/476, 600/310, 600/342, 600/345, 600/477-480, 600/309, 600/486, 600/505, 600/549, 356/39-42, 356/326, 356/432, 356/445
• US Class Current: 600/476
• CPC Class Codes: A61B 5/14553 specially adapted for cerebral tissue

Abstract

A single signal-single probe multiparameter analyzer apparatus for monitoring various parameters of the identical volume element of body tissue, which includes an input signal generator, a single signal guide which transmits input signal in, and transmits output signal out, constituting a single signal-single probe, a signal splitter which splits output signal into two or more parts, filters which separate various components of output signal, detectors which measure the different components of the output signal, a computer and an analog to digital convertor; and algorithms to evaluate the data.

Claims

1. A multisignal-multiprobe multiparameter analyzer apparatus to monitor simultaneously a redox state (NADH), blood volume and a blood flow (MBF) of a substantially identical volume of tissue element, and in a region of the substantially identical volume of tissue element, ECoG (electrocortical activity), the apparatus comprising:

(a) a Multiprobe Assembly, including an optical fiber bundle/light guide comprising 240μ

excitation optical fiber for laser Doppler flowmetry and NADH monitoring to measure the substantially identical volume of tissue element;

(b) at least one electrocortical electrode for measuring ECoG;

(c) at least one reference electrode;

(d) a single housing for containing said Multiprobe Assembly, said at least one electrocortical electrode and said at least one reference electrode, said single housing being built with a cannula connected respectively to;

(e) a Fluorometer Reflectometer Doppler Analyzer (FRDA); and

(f) an amplifier.

2. The apparatus of claim 1, further comprising:

(g) an analog to digital converter for converting a signal from said FRDA and said amplifier; and

(h) a computer for evaluating said signal from said FRDA and said amplifier to determine a brain viability index.

3. The apparatus of claim 2, wherein said Multiprobe Assembly further includes a surrounding dc steady potential electrode and a plurality of tissue ion specific electrodes for measuring a concentration of extracellular ions, said extracellular ions being K⁺, Ca⁺⁺, H⁺ and Na⁺.

4. The apparatus of claim 3, further comprising:

(i) a fiber optic probe for monitoring parenchymal pressure, said probe being contained in said single housing;

(j) a thermocouple electrode for monitoring temperature, said electrode being contained in said single housing;

(k) a pressure transducer contained in said single housing and connected to said computer; and

(l) a temperature meter contained in said single housing and connected to said computer;

wherein said analog to digital converter further converts a signal from said pressure transducer, from said temperature meter and from said plurality of tissue ion electrodes and wherein said computer further evaluates said signal from said pressure transducer, from said temperature meter and from said plurality of tissue ion electrodes to determine a brain function index.