Estrogen or estradiol need determination by vaginal or urethral acidity determination
First Claim
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1. In the method of determining need for estrogen replacement therapy or estrogen or estradiol dose change, the steps that include:
- a) determining local acidity proximate a moist wall surface of the vagina or urethra, as differing from desired threshold level, and in the substantial absence of bacterial vaginosis,b) and administering sufficient estrogen or estradiol to result in change in said acidity toward said level,c) said determining step including providing an elongated carrier, providing a pH indicating detector on the carrier, providing color comparison measurement means, providing a longitudinally elongated receptacle for said carrier and detector, said color comparison measurement means provided in association with the receptacle, and manipulating said detector for visual color comparison with said color comparison measurement means.
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Abstract
In the method of determining need for human estrogen replacement therapy or estrogen or estradiol dose change, the steps include determining local acidity proximate a moist wall surface of the vagina, or urethra, as differing from desired threshold level (pH 4.5), and administering sufficient estrogen or estradiol to result in change in acidity toward such level.
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Citations
23 Claims
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1. In the method of determining need for estrogen replacement therapy or estrogen or estradiol dose change, the steps that include:
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a) determining local acidity proximate a moist wall surface of the vagina or urethra, as differing from desired threshold level, and in the substantial absence of bacterial vaginosis, b) and administering sufficient estrogen or estradiol to result in change in said acidity toward said level, c) said determining step including providing an elongated carrier, providing a pH indicating detector on the carrier, providing color comparison measurement means, providing a longitudinally elongated receptacle for said carrier and detector, said color comparison measurement means provided in association with the receptacle, and manipulating said detector for visual color comparison with said color comparison measurement means. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. In the method of determining need for estrogen or estradiol change, the steps that include:
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a) providing a pH detection means on a carrier stick, b) providing a protective porous layer adjacent said pH detection means, c) manipulating the stick to obtain pH detection of vaginal or urethral moisture, and including allowing vaginal or urethral moisture to penetrate said porous layer for contact with said pH detection means, d) visually observing said detection means, e) and determining from said observed pH detection means a need for a change in estrogen or estradiol level to be administered to a female, f) said method carried out in the absence of bacterial vaginosis, g) said method also including providing color comparison measurement means, providing an elongated receptacle for said detection means and on said carrier stick, said color comparison measurement means provided in association with said receptacle, and including manipulating said detector means for visual color comparison with said color comparison measurement means. - View Dependent Claims (12, 13)
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14. In the method of determining need for human estrogen or estradiol change, the steps that include:
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a) first determining local acidity proximate a moist wall surface of the vagina, or urethra, said determining employed as an indicator of the presence or absence of bacterial vaginosis, b) and, after a vaginosis condition has been treated and eliminated, then again determining local acidity proximate a moist wall surface of the vagina or urethra, as differing from desired threshold level, c) and administering sufficient estrogen or estradiol to result in change in said acidity toward said threshold level, d) said determining step including providing an elongated carrier, providing a pH indicating detector on the carrier, providing color comparison measurement means, providing a longitudinally elongated receptacle for said carrier and detector, said color comparison measurement means provided in association with the receptacle, and manipulating said detector for visual color comparison with said color comparison measurement means. - View Dependent Claims (15, 16, 17, 18, 19)
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20. In the method of employing detected pH of vaginal or urethral moisture in estrogen therapy, the steps that include:
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a) providing an acidity sensing means on a carrier, b) providing a protective porous layer adjacent said sensing means, c) manipulating the carrier proximate vaginal or urethral moisture, and including allowing vaginal or urethral moisture to penetrate said porous layer for contact with said sensing means, d) and detecting a vaginal or urethral moisture produced change in said sensing means, for determining need for a change in estrogen or estradiol dosage, e) said method also including providing color comparison measurement means, providing an elongated receptacle for said sensing means and for said carrier, said color comparison measurement means provided in association with said receptacle, and including manipulating said sensing means for visual color comparison with said color comparison measurement means.
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- 21. The method for measuring pH of vaginal or urethral moisture for determining need for a change in estrogen or estradiol dosage, that includes providing an elongated carrier, providing a pH indicating detector on the carrier, providing color comparison measurement means, providing a longitudinally elongated receptacle for said carrier and detector, said color comparison measurement means provided in association with the receptacle, there being a longitudinal window along which said color comparison measurement means is displayed in the form of bands, and manipulating said detector within the receptacle and along the window for visual color comparison with said bands, after exposure of said detector to vaginal or urethral moisture.
Specification