Electrochemical analytical cartridge
First Claim
1. An analytical cartridge for use in electrochemical analysis of fluids, said cartridge comprising:
- a housing comprising a cartridge body which has a top surface, bottom surface and outer walls defining a housing perimeter, said body further comprising an inner end and outer end;
a deposition well located in said cartridge body for receiving fluid to be analyzed, said deposition well having an inlet and an outlet;
an electrochemical device for measuring the ionic activity of said fluid, said electrochemical device comprising a sample inlet for receiving said fluid and a reference inlet for receiving a reference fluid;
a sample overflow well located in said cartridge body, said overflow well having an inlet and outlet;
a sample metering system which comprises a sample passageway which comprises a first passageway which connects the outlet of said deposition well to the overflow well inlet and a second passageway which connects the outlet of said deposition well to the sample inlet of said electrochemical device, wherein said first and second passageways are integral with each other at said deposition well outlet;
a reference fluid well for housing reference fluid, said reference fluid well having an outlet;
a reference fluid passageway which is connected between said reference fluid well outlet and the reference inlet of said electrochemical device;
a sample pressurization device for pressurizing said deposition well to provide movement of sample fluid from said sample passageway to said electrochemical device; and
a reference fluid pressurization device for pressurizing said reference fluid well to provide movement of reference fluid through said reference fluid passageway.
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0 Petitions
Accused Products
Abstract
An electro-analytical cartridge adapted for use in analyzing fluids. The cartridge includes an electrochemical device that measures ionic activity using ion-specific electrodes. The cartridge further includes a plumbing system composed of the electrochemical device and various wells or chambers which are interconnected by passageways. After introduction into the cartridge, liquid samples are measured out and transported to the electrochemical device utilizing a sequential application of centrifugal force followed by pressurization of the system. Reference fluid is transported from a reference fluid well or reservoir to the electrochemical device for use in measuring ionic activity. The cartridge may be used to measure the ionic activity of a wide variety of ions in fluids including bodily fluids.
196 Citations
17 Claims
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1. An analytical cartridge for use in electrochemical analysis of fluids, said cartridge comprising:
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a housing comprising a cartridge body which has a top surface, bottom surface and outer walls defining a housing perimeter, said body further comprising an inner end and outer end; a deposition well located in said cartridge body for receiving fluid to be analyzed, said deposition well having an inlet and an outlet; an electrochemical device for measuring the ionic activity of said fluid, said electrochemical device comprising a sample inlet for receiving said fluid and a reference inlet for receiving a reference fluid; a sample overflow well located in said cartridge body, said overflow well having an inlet and outlet; a sample metering system which comprises a sample passageway which comprises a first passageway which connects the outlet of said deposition well to the overflow well inlet and a second passageway which connects the outlet of said deposition well to the sample inlet of said electrochemical device, wherein said first and second passageways are integral with each other at said deposition well outlet; a reference fluid well for housing reference fluid, said reference fluid well having an outlet; a reference fluid passageway which is connected between said reference fluid well outlet and the reference inlet of said electrochemical device; a sample pressurization device for pressurizing said deposition well to provide movement of sample fluid from said sample passageway to said electrochemical device; and a reference fluid pressurization device for pressurizing said reference fluid well to provide movement of reference fluid through said reference fluid passageway. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. An analytical cartridge for use in analyzing sample fluids, said cartridge comprising:
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a housing comprising a cartridge body which has a top surface, bottom surface and outer walls defining a housing perimeter, said body further comprising an inner end and outer end; a deposition well located in said cartridge body for receiving sample fluid to be analyzed, said deposition well having an inlet and outlet; a test well comprising a sample inlet for receiving said sample fluid and a reference inlet for receiving a reference fluid; a sample overflow well located in said cartridge body, said overflow well comprising an inlet and outlet; a sample metering system which comprises a sample passageway which comprises a first passageway which connects the outlet of said deposition well to the overflow well inlet and a second passageway which connects the outlet of said deposition well to the sample inlet of said test well, wherein said first and second passageways are integral with each other at said deposition well outlet; a reference fluid well for housing reference fluid, said reference fluid well having an outlet; a reference fluid passageway which is connected between said reference fluid well outlet and the reference inlet of said test well; a sample pressurization device for pressurizing said deposition well to provide movement of sample fluid from said sample passageway to said test well; and a reference fluid pressurization device for pressurizing said reference fluid well to provide movement of reference fluid through said reference fluid passageway. - View Dependent Claims (12, 13, 14, 15, 16, 17)
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Specification