Materials and method for the immobilization of bioactive species onto biodegradable polymers
First Claim
1. A biodegradable material for immobilization of bioactive species thereon, the material comprising:
- a porous hydrophobic biodegradable support member;
a first layer comprised of at least one species of a polymeric surfactant, wherein the polymeric surfactant is adsorbed to the support member, and wherein the surfactant is cross-linked to itself with a cross-linking agent that forms covalent bonds that are subject to enzymatic cleavage or non-enzymatic hydrolysis under in vivo conditions.
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Abstract
The present invention is directed to hydrophobic biodegradable polymeric materials having at least one surface thereof rendered more hydrophilic by attachment of at least one layer of a hydrophilic polymer thereto. The hydrophilic polymer layer is cross-linked together on the surface of the biodegradable material with a cross-linking agent or scheme that is biodegradable. Bioactive species are immobilized to chemically functional groups of the components of the first layer or to unreacted chemically functional groups of the cross-linking agent. Optionally, the bioactive species may be reversibly immobilized through chemically functional linkages that are degradable. The result is an implantable construction with immobilized bioactive species having structural components that are all subject to degradation in the body of a recipient.
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Citations
75 Claims
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1. A biodegradable material for immobilization of bioactive species thereon, the material comprising:
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a porous hydrophobic biodegradable support member; a first layer comprised of at least one species of a polymeric surfactant, wherein the polymeric surfactant is adsorbed to the support member, and wherein the surfactant is cross-linked to itself with a cross-linking agent that forms covalent bonds that are subject to enzymatic cleavage or non-enzymatic hydrolysis under in vivo conditions. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67)
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19. A biodegradable material having bioactive species immobilized thereon, the material comprising:
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a porous hydrophobic biodegradable support member; a first layer comprised of at least one species of a polymeric surfactant, wherein the polymeric surfactant is adsorbed to the support member, wherein the surfactant is cross-linked to itself through acid-base coacervation, carboxyic acid-ether complexation, ion complexation, ionic interactions, metal complexation, or alcoholic hydrogen bonding, and wherein the cross-linked surfactant is subject to degradation under in vivo conditions. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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35. A method of making a material for the immobilization of bioactive species thereon, the method comprising:
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providing a porous hydrophobic biodegradable support member; adsorbing a first layer comprised of at least one type of polymeric surfactant to the support member; and cross-linking the polymeric surfactant to itself with chemical bonds that are subject to degradation in a recipient. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54)
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68. A biodegradable material for immobilization of bioactive species thereon, the material comprising:
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a support member comprising poly(glycolic acid); and a first layer comprising poly(ethyleneimine) adsorbed to the support member, wherein the poly(ethyleneimine) is cross-linked to itself with a cross-linking agent that forms covalent bonds that are subject to enzymatic cleavage or non-enzymatic hydrolysis. - View Dependent Claims (69, 70, 71)
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72. A biodegradable material for immobilization of bioactive species thereon, the material comprising:
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a support member comprising a copolymer of glycolide and trimethylene carbonate; and a first layer comprising poly(ethyleneimine) adsorbed to the support member, wherein the poly(ethyleneimine) is cross-linked to itself with a cross-linking agent that forms covalent bonds that are subject to enzymatic cleavage or non-enzymatic hydrolysis. - View Dependent Claims (73, 74, 75)
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Specification