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Composition and method using solid-phase particles for sustained in vivo release of a biologically active agent

  • US 5,916,597 A
  • Filed: 08/29/1996
  • Issued: 06/29/1999
  • Est. Priority Date: 08/31/1995
  • Status: Expired due to Term
First Claim
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1. A pharmaceutical composition for the sustained release in vivo of a biologically active agent, comprising:

  • a) microcarrier particles of about one millimeter or less containing an effective amount of a biologically active agent encapsulated within a first polymer which biocompatible and selected from the group consisting of poly(lactide)s, poly(glycolide)s, poly(lactide-co-glycolide)s, poly(lactic acid)s, poly(glycolic acid)s, poly(lactic acid-co-glycolic acid)s, polycaprolactone, polycarbonates, polyesteramides, polyanhydrides, poly(amino acids), polyorthoesters, polyacetyls, polycyanoacrylates, polyetheresters, poly(dioxanone)s, poly(alkylene alkylate)s, copolymers of polyethylene glycol and polyorthoester, biodegradable polyurethanes, blends and copolymers thereof, wherein the microcarriers sustain the in vivo release of the biologically active agent, andb) microparticles of about one millimeter or less of a second polymer which is biocompatible and biodegradable, wherein said microparticles are substantially free of the biologically active agent, and which are separate form but commingled with the microcarrier particles of a) and are present in an amount sufficient to elongate the release period of biologically active agent from the microcarrier particles of a).

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