System and method for treating cellular disorders in a living being

• US 5,919,135 A
• Filed: 02/28/1997
• Issued: 07/06/1999
• Est. Priority Date: 02/28/1997
• Status: Expired due to Term

• Current Assignee: Jerome H. Lemelson
• Original Assignee: Jerome H. Lemelson
• Inventors: Lemelson, Jerome
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): SHAW, SHAWNA JEANNINE
• Application Number:
  US08/807,646
• Time in Patent Office: 858 Days
• Field of Search: 600/407, 600/408, 600/410, 600/411, 600/419, 600/420, 600/432, 600/433, 600/436, 600/437, 600/3-5, 128/920, 128/925, 604/4, 604/19, 604/27, 604/28, 604/30, 604/35, 604/36, 604/48, 604/49, 604/51, 604/52, 604/53, 607/901, 378/4
• US Class Current: 600/407
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/704 Tables
• CPC Class Codes: A61B 6/0421 with immobilising means
• CPC Class Codes: A61B 6/481 involving the use of contrast agents
• CPC Class Codes: A61B 6/504 for diagnosis of blood vessels, e.g. by angiography

Abstract

A system and method is provided for the treatment of hypreproliferative diseases, such as cancer, using real-time computer control to visualize, to position and to operate drug infusing and imaging devices within the body of the patient. The invention employs a computerized imaging system (such as CAT scan, MRI imaging, ultrasound imaging, infrared, X-ray, UV/visible light fluorescence, Raman spectroscopy, single photon emission computed tomography or microwave imaging) to sense the position of a drug infusing catheter within the body. In a preferred embodiment, the invention provides real-time computer control to maintain and adjust the position of an infusion catheter and/or the position of the patient relative to the infusion catheter; and also provides real-time computer control of the operation of the infusion catheter based on images and/or computer models of the dispersion of one or more cytotoxic or other drugs or therapeutically active agents through the vascular bed of the neoplastic tissue being treated. In other preferred embodiments of the invention, vasoconstrictive drugs are applied locally based on computer modeling of blood flow patterns in order to channel blood flow carrying the cytotoxic drug or other therapeutic agent into the neoplastic tissue, and to minimize exposure of healthy tissue to such drugs.

Claims

1. A method for treating a tumor in a body which is in communication with arterial and venous blood flow comprising:

a. mapping the surface and volume of said tumor;

b. locating the arteries upstream of said tumor;

c. calculating an optimum controlled dose of a cytotoxic drug suitable for treating said tumor;

d. infusing a controlled dose of said cytotoxic drug into said tumor from one or more of said arteries at select locations upstream of said tumor; and

e. withdrawing blood from one or more veins at select locations downstream of said tumor for extracorporeal treatment to remove said cytotoxic drug from the blood withdrawn whereby a substantial portion of said cytotoxic drug is infused into said tumor and prevented from diffusing into said body.

2. The method of claim 1, further comprising controlling the dispersion of said cytotoxic drug by injecting a vasoconstrictive drug into said arteries at select locations downstream of the select locations upstream for infusion of said cytotoxic drug of said cytotoxic drug.

3. The method of claim 1, further comprising locating the veins downstream of said tumor, and controlling the dispersion of said cytotoxic drug by injecting a vasoconstrictive drug at select locations into said veins.

4. The method of claim 3, further comprising alternately injecting and withdrawing fluid containing a cytotoxic agent at said select locations within said arteries.

5. The method of claim 1, further comprising injecting cleansed blood into said one or more downstream veins, downstream of said select locations upstream for the infusion of said cytotoxic drug.

6. The method of claim 5, further comprising using one or more dual-lumen catheters having longitudinally spaced injection and withdrawal apertures to accomplish removal and injection of blood from said veins.

7. The method of claim 1, further comprising effecting visualization of said tumor using a solution of monoclonal antibodies specific to said tumor conjugated to an imaging marker.

8. The method of claim 1, further comprising effecting visualization of blood flow within said tumor using an angiographic contrast medium.

9. The method of claim 1, further comprising predicting the pattern and concentration of dispersion of said cytotoxic drug within said tumor using potential flow modeling.

10. The method of claim 1, further comprising sealing off said arteries at locations downstream of said select locations upstream for the infusion of said cytotoxic drug.

11. The method of claim 10, wherein said arteries are sealed off by laser cauterization.

12. The method of claim 1, further comprising predicting the pattern and concentration of dispersion of said cytotoxic drug within said tumor using one or more neural networks.

13. The method of claim 1, wherein said cytotoxic drug is selected from the group consisting of alkylating agents, enzyme inhibitors, proliferation inhibitors, lytic agents, DNA synthesis inhibitors, membrane permeability modifiers, DNA intercalators and, antimetabolites.

14. The method of claim 2 or 3, wherein said vasoconstrictive drug is selected from the group consisting of catecholamines, norepinephrine, epinephrine, isoproterenol, dopamine, ephedrine phenylisopropylamines, phenylephrine, amphetamine, metraminol, methoxamine;

ergot alkaloids including lysergic acid, lysergic acid diethylamine, ergonovine, methylergonavine, methysergide, ergotamine;

angiotensins; and

prostaglandins.

15. The method of claim 1, further comprising infusing a sensitizing agent into said tumor.

17. The method of claim 1, wherein said visualizing of said tumor is accomplished by the group consisting of computerized axial tomography (CAT scanning), magnetic resonance imaging (MRI), ultrasonography, positron emission tomography (PET), single-photon emission computed tomography (SPECT), infrared sensing, X-ray imaging and microwave imaging.

16. The method of claim 16, wherein said sensitizing agent is selected from the group consisting of radionuclides of technicium or iridium;

nitroimidazoles;

halogenated pyrimidines (BUdR);

methylated xanthines;

cytokines;

interferons;

lymphokines;

interleukin-2;

tumor necrosis factor; and

transforming growth factor-beta.