Electrical impedance tomography method and apparatus

• US 5,919,142 A
• Filed: 12/19/1997
• Issued: 07/06/1999
• Est. Priority Date: 06/22/1995
• Status: Expired due to Fees

• Current Assignee: BTG International Limited (Boston Scientific Corporation)
• Original Assignee: BTG International Limited (Boston Scientific Corporation)
• Inventors: Boone, Kevin Graham, Holder, David Simon
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US08/994,757
• Time in Patent Office: 564 Days
• Field of Search: 600/547
• US Class Current: 600/547
• CPC Class Codes: A61B 5/0042 for the brain
• CPC Class Codes: A61B 5/0522 Magnetic induction tomography
• CPC Class Codes: A61B 5/0536 Impedance imaging, e.g. by tomography

Abstract

A method and apparatus for use in imaging a body uses electrical impedance tomography (EIT). A plurality of electrodes are provided in electrical contact with the body around the periphery of the body. A first electrical input signal is applied to at least one of the electrodes over a first time period, and a second electrical input signal, which is preferably in inverted form of the first, then applied to the at least one of the electrodes over a subsequent, second time period. The resulting electrical output signal is measured at one or more pairs of the remaining electrodes over the first and second time periods and the difference between the measured signal obtained during the first time period and that obtained during the second time period is calculated to provide a difference signal. The difference signal can stored and used for image reconstruction. The invention has particular application in imaging neurological function within the body, where the impedance changes associated with neuronal depolarizations are very small and the resulting electrical signals measured at the body periphery are even smaller. By use of this technique electrical signals corresponding to the dynamic components of impedance change can be reinforced whilst those corresponding to other unwanted components can be cancelled.

Claims

1. A method for use in imaging a body by means of the technique of electrical impedance tomography (EIT), the method comprising:

providing a plurality of electrodes in electrical contact with the body around the periphery of the body;

applying a stimulus to the body;

applying a first electrical input signal to at least one of the electrodes over a first time period;

applying a second electrical input signal to the at least one of the electrodes over a subsequent, second time period, wherein the second signal is an inverted form of the first electrical input signal;

measuring the resulting electrical output signal at one or more pairs of the remaining electrodes over the first and second time periods; and

calculating the difference between the measured signal obtained during the first time period and that obtained during the second time period, to provide a difference signal.

2. A method according to claim 1, wherein the first and second electrical input signals are unidirectional signals of equal and respectively opposite sign.

3. A method according to any preceding claim, wherein the applications of the first electrical input signal and that of the second electrical input signal are continuously alternated, the first and second time periods being equal, and the electrical signal measurements are taken at regular intervals during each time period.

4. A method according to claim 1, wherein the measurement is carried out on a number of different pluralities of electrodes, and images representative of the body are generated using said difference signal.

5. A method according to claim 1, wherein the signal application is carried out in synchronization with the application of the stimulus signal to the body.

6. A method according to claim 1, wherein the first and second time periods are each between 0.1 and 1.0 seconds.

7. Apparatus for use in imaging a body suitable for use in the technique of electrical impedance tomography (EIT), the apparatus comprising:

a plurality of electrodes adapted for electrical contact with the body around the periphery of the body;

means for applying a first electrical input signal to at least one of the electrodes over a first time period;

means for applying a stimulus signal to the body;

means for providing an inverted form of the first electrical signal to produce the second electrical signal;

means for applying the second electrical input signal to the at least one of the electrodes over a second, subsequent time period;

means for measuring the resulting electrical output signals at one or more pairs of the remaining electrodes over the first and second time periods; and

means for calculating the difference between the measured signal obtained during the first time period and that obtained during the second time period, to provide a difference signal.

8. Apparatus according to claim 7, further comprising:

an electrical current generator electrically isolated from the measuring means, and

wherein the means for providing the inverted form of the first electrical input signal comprises a switching means controlling the electrical current generator.

9. Apparatus according to claim 8, wherein the electrical current generator is electrically isolated from the measuring means by one or more optical isolators.