Electrotransport system having flexible connector means

• US 5,919,155 A
• Filed: 01/18/1995
• Issued: 07/06/1999
• Est. Priority Date: 12/31/1992
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Albert, Charles, Gilbert, Scott Jay, Gyory, J. Richard, Lattin, Gary A.
• Primary Examiner(s): Bockelman, Mark
• Application Number:
  US08/374,006
• Time in Patent Office: 1,630 Days
• Field of Search: 439/29, 439/592, 439/840, 439/909, 604/20-21, 607/115, 607/148, 607/149, 607/152
• US Class Current: 604/20
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0448 Drug reservoir
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
• CPC Class Codes: A61N 1/303 Constructional details electrodes for external use A61N1/0428
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428
• CPC Class Codes: Y10S 439/909 Medical use or attached to human body

Abstract

A device (10) for the electrically assisted delivery of a therapeutic agent is described. The device (10) has rigid zones or regions (12, 14) which are physically connected by a flexible means (16) such as a web. The flexible means (16) permits the rigid zones (12, 14) to move independently with respect to each other while remaining physically connected or coupled. In a preferred embodiment, the rigid zones are physically and electronically coupled by the flexible means. In another embodiment, the device (500) comprises one or more rigid zones, the skin side of the rigid zone having a radius of curvature (520) which approximates that of the body site to which the device (500) is to be attached. A method of increasing the body surface conformability of an electrotransport device (50, 150, 170) is described. The method involves the step of intentionally placing rigid subcomponents (58, 36, 37) of the device in physically separate zones (52, 54; 152, 154, 156, 158; 172, 174, 176, 178) within the device. The rigid zones (52, 54; 152, 154, 156, 158; 172, 174, 176, 178) are separate and are coupled by flexible connector means (56, 62; 160, 162). In this manner, a conformable mosaic of rigid zones which comprises the device is created.

Claims

1. A device for delivering an agent by electrotransport through a body surface, the device having a source of electrical power electrically connected to a pair of electrode assemblies, one of the pair of electrode assemblies having a reservoir for containing the agent to be delivered, the device comprising at least two regions which are placed against the body surface at spaced apart locations and which are held in intimate contact with said body surface, at least one of the two regions being rigid and comprising the power source and an electrode assembly, the regions being physically connected to one another by a connector, the connector having a folded non-extended configuration and an unfolded extended configuration, whereby the regions may be placed on the body surface at:

(i) a first set of locations when the connector is in the folded non-extended configuration, or (ii) a second set of locations less proximate that the first set of locations when the connector is in the extended unfolded configuration.

2. The device of claim 1, wherein the first set of locations is more closely spaced than the second set of locations.

3. The device of claim 1, wherein the connector is accordion shaped or serpentine shaped.

4. The device of claim 3, wherein the connector is comprised of a plurality of overlapping portions when in the non-extended configuration, at least some of the overlapping portions becoming non-overlapping when the connector is in the extended configuration.

5. The device of claim 1, wherein the connector is flexible and has a flexural rigidity of less than about 0.75×

10^-3 kg-m² /rad.

6. The device of claim 1, wherein the connector is flexible and has a flexural rigidity of less than about 0.45×

10^-3 kg-m² /rad.

7. The device of claim 1, wherein at least one of the regions comprises an electronic assembly electrically connected to the power source.

8. The device of claim 1, wherein at least one of the regions consists essentially of an electrode assembly.

9. The device of claim 1, wherein each of the regions comprises an electrode assembly.

10. The device of claim 1, wherein the connector permits angular movement of one region relative to another region.

11. The device of claim 10, wherein the connector permits the regions to deviate from substantial planarity by at least about 15 degrees.

12. The device of claim 1, wherein the connector permits adjustable positioning of one region on the body surface relative to the positioning of another region on the body surface.

13. The device of claim 1, wherein the connector includes an electrical conductor which electrically connects one of the regions to an electrical component in another region.

14. The device of claim 13, wherein the electrical conductor electrically connects an electrode assembly to an electronic controller.

15. The device of claim 13, wherein the electrical conductor comprises an electrically conductive trace.

16. The device of claim 15, wherein the trace is comprised of an electrically conductive ink.

17. The device of claim 1, wherein the connector is comprised of a substrate having an electrically conductive ink trace.

18. The device of claim 17, wherein the substrate comprises a multi-laminate including a layer of foam and an ink-printable polyester sheet.

19. The device of claim 1, wherein the reservoir contains a locally acting agent.

20. The device of claim 1, wherein the reservoir contains an agent selected from the group consisting of local anesthetics, anti-inflammatory agents, anti-fungal agents, wart-removing agents, anti-tumor agents, anti-spasmodic agents and erection-inducing agents.