Transdermal system for simultaneous delivery of a number of active principles
First Claim
1. A system for the simultaneous transdermal delivery of at least two active principles from at least two juxtaposed devices, said system comprising:
- (a) a first device containing a mixture of all the active principles in which at least one first active principle (A) is present in an amount which enables the effective therapeutic dose to be delivered, and at least one second active principle (B) is present in an amount which is less than that required to deliver the therapeutic dose, and(b) one or more additional devices each containing a single active principle (B) selected from those present in the first device and provided in an amount which is less than that required to deliver the effective therapeutic dose, the sum total of the amount in said additional device(s) making up the balance of the effective therapeutic dose of each of the active principles (B) present in the system.
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Accused Products
Abstract
A novel system for percutaneously delivering at least two active principles, consisting of at least two juxtaposed devices. The system includes (i) a first device containing a mixture of all the active principles in which at least one first active principle (A) is present in an amount enabling the effective therapeutic dose to be delivered, and at least one second active principle (B) is present in an amount smaller than the amount needed to deliver the effective therapeutic dose; and (ii) one or more additional devices each containing a single active principle (B) selected from those in the first device and provided in an amount smaller than the amount needed to deliver the effective therapeutic dose, said additional device(s) being designed to top up the amount of each of the active principles (B) in the system until the effective therapeutic dose is achieved.
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Citations
20 Claims
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1. A system for the simultaneous transdermal delivery of at least two active principles from at least two juxtaposed devices, said system comprising:
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(a) a first device containing a mixture of all the active principles in which at least one first active principle (A) is present in an amount which enables the effective therapeutic dose to be delivered, and at least one second active principle (B) is present in an amount which is less than that required to deliver the therapeutic dose, and (b) one or more additional devices each containing a single active principle (B) selected from those present in the first device and provided in an amount which is less than that required to deliver the effective therapeutic dose, the sum total of the amount in said additional device(s) making up the balance of the effective therapeutic dose of each of the active principles (B) present in the system. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 20)
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18. A method for simultaneous transdermal delivery of at least two active principles to a mammal in need of treatment comprising the steps of:
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(a) providing a system comprising at least two juxtaposed devices, said system comprising; (i) a first device containing a mixture of all the active principles comprising at least one first active principle (A), and at least one second active principle (B); and (ii) one or more additional devices each containing a single active principle (B) selected from the active principles present in the first device; (b) delivering at least two active principles in the first device wherein the first active principle (A) being present in an amount effective to provide the therapeutic dose; and
the second active principle (B) being present in an amount less than the required effective therapeutic dose;c) conducting the delivery of a single active principle (B) in the one or more additional devices being present in an amount which is less than that required to deliver the effective therapeutic dose, said additional device or devices making up the amount of each of the active principle (B) present; and (d) continuing the delivery steps (b) and (c) until the effective therapeutic dose is reached. - View Dependent Claims (19)
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Specification