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Derivatization of solid supports and methods for oligomer synthesis

  • US 5,919,523 A
  • Filed: 10/24/1997
  • Issued: 07/06/1999
  • Est. Priority Date: 04/27/1995
  • Status: Expired due to Term
First Claim
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1. A method of preparing a polymer-coated support for use in solid-phase synthesis using in situ polymerization, comprising:

  • (a) preparing a mixture comprising monomers and a polymerization initiator to initiate polymerization of the monomers;

    (b) contacting a support derivatized with a derivatizing agent having a substrate attaching group attached to the support and a reactive site distal to the support with said mixture to form a polymer linked to the support via the reactive site on the derivatizing agent.

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