Derivatization of solid supports and methods for oligomer synthesis
First Claim
Patent Images
1. A method of preparing a polymer-coated support for use in solid-phase synthesis using in situ polymerization, comprising:
- (a) preparing a mixture comprising monomers and a polymerization initiator to initiate polymerization of the monomers;
(b) contacting a support derivatized with a derivatizing agent having a substrate attaching group attached to the support and a reactive site distal to the support with said mixture to form a polymer linked to the support via the reactive site on the derivatizing agent.
4 Assignments
0 Petitions
Accused Products
Abstract
Methods and derivatized supports which are useful in solid-phase synthesis of peptides, oligonucleotides or other small organic molecules as well as arrays of ligands. The methods provide means to control the functional site density on a solid support. Some of the derivatized supports are polymer-coated or glycan-coated. Other methods for regenerating the surface of a used ligand array are also provided.
-
Citations
7 Claims
-
1. A method of preparing a polymer-coated support for use in solid-phase synthesis using in situ polymerization, comprising:
-
(a) preparing a mixture comprising monomers and a polymerization initiator to initiate polymerization of the monomers; (b) contacting a support derivatized with a derivatizing agent having a substrate attaching group attached to the support and a reactive site distal to the support with said mixture to form a polymer linked to the support via the reactive site on the derivatizing agent. - View Dependent Claims (2, 3, 4, 5, 6, 7)
-
Specification