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Slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly(N-vinylpyrrolidone) polymer hydrogel, coated polymer and metal substrate materials, and coated medical devices

  • US 5,919,570 A
  • Filed: 02/01/1995
  • Issued: 07/06/1999
  • Est. Priority Date: 02/01/1995
  • Status: Expired due to Term
First Claim
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1. A material bearing thereon a coating of a wet, slippery, tenaciously adhering, commingled hydrogel of a hydrophilic polyurethane-polyurea polymer hydrogel and a poly(N-vinylpyrrolidone) polymer hydrogel, said material and coating comprising:

  • a) a hydrophilic or hydrophilicized hydrophobic polymer substrate or a metal substrate, having a surface with reactive chemical functional groups thereon, at least some of which are amine-containing groups;

    b) a first coating, applied onto said substrate surface, said first coating being a hydrophilic polyurethane-urea prepolymer intermediate, that is capable of forming a polyurethane-polyurea hydrogel-forming polymer, and that contains terminal isocyanate groups that are free to react with other species, such that at least some of said terminal isocyanate groups are reacted with and are covalently bonded to said reactive chemical functional groups on said substrate surface, forming covalent polyurea bonds therewith, resulting in the formation of a tie coat of a polyurethane-polyurea hydrogel-forming polymer, on said substrate surface, such that said polyurethane-polyurea hydrogel-forming polymer tenaciously adheres to said substrate surface; and

    wherein at least some of said terminal isocyanate groups of said polyurethane-urea prepolymer intermediate are present in said polyurethane-polyurea hydrogel-forming polymer such that they remain free to react with other species; and

    c) a second coating, applied onto said tie coat, said second coating being an aqueous solution of a poly(N-vinylpyrrolidone) hydrogel-forming polymer, such that a barrier coat which is a commingled hydrogel of a polyurethane-polyurea polymer hydrogel and a poly(N-vinylpyrrolidone) polymer hydrogel is formedwherein water of said aqueous solution of said poly(N-vinylpyrrolidone) hydrogel-forming polymer is bound with said polyurethane-polyurea hydrogel-forming polymer to form a polyurethane-polyurea polymer hydrogel;

    wherein water of said aqueous solution of said poly(N-vinylpyrrolidone hydrogel-forming polymer is bound with said poly(N-vinylpyrrolidone) hydrogel-forming polymer to form a poly(N-vinylpyrrolidone polymer hydrogel; and

    wherein said poly(N-vinylpyrrolidone polymer hydrogel is adherent to said substrate surface as a result of being commingled with said polyurethane-polyurea polymer hydrogel.

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