System and method for delivery of neutron beams for medical therapy

• US 5,920,601 A
• Filed: 10/21/1997
• Issued: 07/06/1999
• Est. Priority Date: 10/25/1996
• Status: Expired due to Fees

• Current Assignee: Battelle Energy Alliance LLC (Battelle Memorial Institute)
• Original Assignee: Lockheed Martin Postal Technologies Inc (Opex Corporation)
• Inventors: Wemple, Charles A., Nigg, David W.
• Primary Examiner(s): Wasil, Daniel D.
• Assistant Examiner(s): Lattig, M. J.
• Application Number:
  US08/955,194
• Time in Patent Office: 623 Days
• Field of Search: 376/190, 376/194, 376/156, 376/158, 376/112, 350/505.1, 350/518.1, 350/251, 600/1
• US Class Current: 376/194
• CPC Class Codes: A61N 2005/109 Neutrons
• CPC Class Codes: A61N 2005/1095 Elements inserted into the radiation path within the system, e.g. filters or wedges
• CPC Class Codes: A61N 5/10 X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy A61N5/01 takes precedence
• CPC Class Codes: G21K 5/04 with beam-forming means
• CPC Class Codes: H05H 3/06 Generating neutron beams targets for producing nuclear reactions H05H6/00; neutron sources G21G4/02

Abstract

A neutron delivery system that provides improved capability for tumor control during medical therapy. The system creates a unique neutron beam that has a bimodal or multi-modal energy spectrum. This unique neutron beam can be used for fast-neutron therapy, boron neutron capture therapy (BNCT), or both. The invention includes both an apparatus and a method for accomplishing the purposes of the invention.

Claims

1. A neutron delivery system providing improved capability for tumor control during medical therapy, the system comprising:

a means for producing a proton beam;

at least one target;

a means for directing the proton beam into the at least one target;

said at least one target comprising means for producing, when impacted by the proton beam, at least one neutron beam having a bimodal energy spectrum for use with both fast-neutron therapy and boron neutron capture therapy; and

a collimator wherein the at least one neutron beam passes prior to delivery to a patient.

2. The neutron delivery system of claim 1 wherein the means for producing a proton beam comprises a particle accelerator.

3. The neutron delivery system of claim 2 wherein the particle accelerator comprises a cyclotron.

4. The neutron delivery system of claim 3 wherein the cyclotron comprises a compact superconducting cyclotron.

5. The neutron delivery system of claim 1 wherein the means for producing a proton beam comprises means for producing a proton beam in the 50-70 MeV range.

6. The neutron delivery system of claim 1 wherein the means for directing the proton beam into the at least one target comprises a proton beam bending magnet system.

7. The neutron delivery system of claim 1 wherein the at least one target comprises means for producing at least one neutron beam having a high energy component in the 30-60 MeV range and a low-energy component in the 10 KeV to 2 MeV range.

8. The neutron delivery system of claim 1 wherein the at least one target comprises a plurality of layers having means for producing at least one neutron beam that is a single tailored neutron beam with certain energies being suppressed and other energies being enhanced.

9. The neutron delivery system of claim 8 wherein the plurality of layers of the at least one target comprises:

a proton-neutron conversion region;

a spectral filter means for producing a neutron beam from the neutron filtering subassembly, the means adjustable by an operator for producing a spectrum having a bimodal shape; and

a plurality of filters for flattening and wedging purposes wherein the neutron beam is flattened and tilted, the plurality of filters being operator-controlled so that the low-energy component of the neutron beam can be reduced when it is desired to administer fast-neutron therapy alone, without neutron capture therapy augmentation.

10. The neutron delivery system of claim 9 wherein the proton-neutron conversion region comprises a layer of beryllium operably attached to a layer of tungsten.

11. The neutron delivery system of claim 10 wherein the layer of beryllium has a thickness of between about 3 to about 10 millimeters and wherein the layer of tungsten has a thickness of between about 1 to about 7 millimeters.

12. The neutron delivery system of claim 9 wherein the neutron filtering subassembly comprises neutron cross section characteristics suitable for effecting the desired spectral modification of the beam.

13. The neutron delivery system of claim 9 wherein the spectral filter means further tailors the tailored neutron beam into a desired multi-modal spectral shape such that when the neutron beam impinges upon a volume of hydrogenous tissue (the "treatment volume"), the resulting absorbed radiation dose-depth profile induced by such neutrons has a half-value depth of at least from about 17 to about 21 centimeters when such neutron beam is collimated to transverse dimensions of 20 centimeters by 20 centimeters and such that when the collimated neutron beam impinges on the treatment volume a scaler thermal-neutron fluency field of from about 2 to about 5×

10¹⁰ neutron per square centimeter (2200 meters per second equivalent) per 100 centigrays of fast neutron dose is simultaneously generated at a 5 centimeter depth on-axis.

14. The neutron delivery system of claim 13 wherein the spectral filter means comprises tungsten, bismuth, and iron, and a hydrogeneous material.

15. The neutron delivery system of claim 9 wherein the bimodal shape of the spectrum is a function of energy as the result of the action of the target and filter.

16. The neutron delivery system of claim 9 wherein the plurality of filters for flattening and wedging purposes are composed of tungsten and iron.

17. The neutron delivery system of claim 16 wherein the plurality of filters for flattening and wedging purposes additionally comprise a hydrogenous material for reducing the low-energy component of the spectrum.

18. The neutron delivery system of claim 17 wherein the hydrogenous material comprises polyethylene.

19. The neutron delivery system of claim 1 wherein the collimator comprises a multi-segment collimator for the neutron beam to pass through prior to delivery to the patient at an isocenter.

20. The neutron delivery system of claim 1 wherein the collimator comprises iron and bismuth.

21. The neutron delivery system of claim 1 wherein a balanced rotating structure houses the system and wherein the balanced rotating structure comprises a rotating isocentric gantry means to contain all system components in a manner such that the neutron beam from the collimator is easily moved for exposing the target to be treated in different directions.

22. The neutron delivery system of claim 21 wherein the balanced rotating structure for housing the system comprises:

a housing that is mounted in a large circular opening in an interior wall of a building where the system is installed, said housing being mounted on roller bearings within the interior wall;

said interior wall being providing neutron shielding;

a ring gear wrapped circumferentially around a periphery of the housing; and

at least one drive motor mechanically coupled to the ring gear to engage the ring gear and facilitate rotation of the balanced rotating structure, wherein the structure is rotated about an isocenter.

23. A neutron delivery system providing improved capability for tumor control during medical therapy, the system comprising:

a means for producing a proton beam in the 50-70 MeV energy range;

a target comprising means for producing a tailored neutron beam having a high-energy component in the 30-50 MeV range and a low-energy component in the 10 KeV to 2 MeV range;

a means for directing the proton beam onto the target which produces a neutron beam in response to such proton beam/target interaction;

a spectral filter means immediately downstream of the target and which further tailors the tailored neutron beam into a desired bimodal spectral shape such that when the neutron beam impinges upon a volume of hydrogenous tissue (the "treatment volume"), the resulting absorbed radiation dose-depth profile induced by such neutrons has a half-value depth of at least from about 17.0 to about 21.0 centimeters when such neutron beam is collimated to transverse dimensions of 20 centimeters by 20 centimeters and such that when the collimated neutron beam impinges on the treatment volume a scaler thermal-neutron fluency field of from about 2 to about 5×

10¹⁰ neutron per square centimeter (2200 meters per second equivalent) per 100 centigrays of fast neutron dose is simultaneously generated at a 5 centimeter depth on-axis;

a flattening and wedge filter means downstream of the spectral filter means and having additional components to selectively reduce the low energy component of the neutron beam when it is desired to administer fast-neutron therapy alone, without neutron capture therapy augmentation; and

a collimator means for directing the one or more neutron beams to a desired target to be treated.

24. A method for using a neutron delivery system to provide improved tumor control capability during medical therapy, the method comprising:

producing a proton beam;

directing the proton beam into at least one target;

creating at least one neutron beam having a bimodal energy spectrum for use with both fast-neutron therapy and boron neutron capture therapy, the at least one neutron beam being created upon impact of the proton beam with the at least one target;

tailoring the at least one neutron beam by means of a collimator;

delivering the tailored at least one neutron beam to a patient; and

housing the system in a balanced rotating structure for ease of adjustment.

25. The method of claim 24 wherein the step of producing a proton beam comprises producing a proton beam in the 50-70 MeV energy range.

26. The method of claim 24 wherein the step of producing a proton beam comprises producing a proton beam with a superconducting cyclotron.

27. The method of claim 24 wherein the step of creating at least one neutron beam having a bimodal energy spectrum comprises creating at least one neutron beam having a high energy component in the 30-70 MeV range and a low-energy component in the 10 KeV to 2 MeV range.

28. The method of claim 24 wherein the step of creating at least one neutron beam comprises creating a single tailored neutron beam by exposing a target means with the neutron beam and by the use of filters to eliminate or enhance neutrons of certain energies.

29. The method of claim 28 further comprising the step of passing the tailored neutron beam through a spectral filter means which further tailors the tailored neutron beam into a desired multi-modal spectral shape such that when the neutron beam impinges upon a volume of hydrogenous tissue (the "treatment volume"), the resulting absorbed radiation dose-depth profile induced by such neutrons has a half-value depth of from at least about 17 to about 21 centimeters when such neutron beam is collimated to transverse dimensions of 20 centimeters by 20 centimeters and such that when the collimated neutron beam impinges on the treatment volume a scaler thermal-neutron fluency field of from about 2 to about 5×

10¹⁰ neutron per square centimeter (2200 miles per second equivalent) per 100 centigrays of fast neutron dose is simultaneously generated at a 5 centimeter depth on-axis.