Microfluidic sub-millisecond mixers
First Claim
Patent Images
1. A method of mixing liquids, comprising:
- obtaining a first and second liquid;
obtaining a micro-machined chip, with a substrate that has a first mixer integrated with a second mixer;
mixing said first and second liquid at a Reynolds number greater than 2000 and at a flow rate greater than 250 μ
L/s.
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Abstract
A micromachined, high Reynolds number, sub-millisecond liquid mixer for the study of chemical reaction kinetics. This bulk micromachined silicon mixer is capable of initiating and quenching chemical reactions in intervals as short as 100 μs. The mixer chip contains two tee mixers connected by one channel which serves as a reaction chamber. Each tee mixer consists of opposing channels where liquids meet head-on and exit into a third channel forming the base of a "T".
246 Citations
33 Claims
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1. A method of mixing liquids, comprising:
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obtaining a first and second liquid; obtaining a micro-machined chip, with a substrate that has a first mixer integrated with a second mixer; mixing said first and second liquid at a Reynolds number greater than 2000 and at a flow rate greater than 250 μ
L/s.
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2. An apparatus for mixing, comprising:
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a support substrate; a first reactant inlet area formed on said support substrate; a second reactant inlet area formed on said support substrate; a inhibitor inlet area formed on said support substrate; a reservoir outlet hole formed in said support substrate; a system of fluid channels formed on said support substrate, wherein said fluid channels include a first reactant channel extending from said first reactant inlet area to said inhibitor inlet area, a second reactant channel extending from said second reactant channel to said inhibitor inlet area, a delay channel, an inhibitor channel, and a reservoir channel, said delay channel is positioned at a first intersection of said first reactant channel and said second reactant channel, said inhibitor channel is positioned to feed liquid out of said inhibitor inlet area, said reservoir channel is positioned at a second intersection of said inhibitor channel and said delay channel; a first mixer, positioned at said first intersection having a shape to mix fluids; a second mixer positioned at said second intersection having a shape to mix fluids; a cover layer having a first hole corresponding to said first reactant inlet area, a second hole corresponding to said second reactant inlet area, and a third hole corresponding to said inhibitor inlet area, said cover layer being bonded to said support layer. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9)
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10. An apparatus for mixing on a substrate, comprising:
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a first mixer formed in said silicon substrate; a second mixer also formed in said silicon substrate; a system of fluid channels each formed in said silicon substrate including a delay fluid channel, connecting said first mixer to said second mixer. - View Dependent Claims (11, 12, 13, 14, 15, 16)
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17. An apparatus comprising:
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a mixer chip, wherein said mixer chip having a system of fluid channels connecting a plurality of mixers on a common substrate; a flow regulation device, wherein said mixer chip is positioned to interface with said flow regulation device. - View Dependent Claims (18, 19, 20)
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21. A mixer apparatus comprising:
a mixer chip, wherein said mixer chip having a system of fluid channels connecting a plurality of mixers, said mixers operating at Reynolds number greater than 2000, said mixers capable of initiating and quenching chemical reactions in intervals of shorter than 100 microseconds.
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22. A method of characterizing a mixer, comprising:
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performing a first order chemical reaction with a specified time constant; and characterizing said mixer based on a result of said performing. - View Dependent Claims (23, 24)
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25. A method of characterizing a mixer, comprising:
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performing visualization techniques using a visual indicator; and using said visualization techniques to characterize said mixer. - View Dependent Claims (26, 27)
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28. A method for mixing, comprising:
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first obtaining a first fluid sample; second obtaining a second fluid sample; forming a fluid channel with an intersection on a support substrate; injecting said first and second fluid sample into said fluid channel wherein said first and second fluid samples meet head-on at said intersection forming a fluid flow; forming sharp-edged structures in said fluid channel; breaking said fluid flow with said sharp-edged structures thereby increasing turbulence.
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29. An apparatus for mixing, comprising:
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a fluid channel having a channel roof and a channel floor; a plurality of sharp-edged structures positioned within said fluid channel with at least one end connected to said channel roof or said channel floor. - View Dependent Claims (30)
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31. A method for mixing, comprising:
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forming a first fluid channel, a second fluid channel, and a third fluid channel wherein said first, second, and third fluid channel forms an intersection; first injecting a first liquid sample at a first fluid velocity in said first fluid channel; second injecting a second liquid sample at a second fluid velocity in said second fluid channel, wherein said first liquid sample and said second liquid sample meet at said intersection; flowing said first liquid sample and said second liquid sample out of said intersection into said third fluid channel at an angle.
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32. A method as in 31, wherein said first fluid velocity and said second fluid velocity are similar.
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33. A method as in 32, wherein said angle is 90 degrees.
Specification