Extracorporeal blood processing methods and apparatus

• US 5,921,950 A
• Filed: 10/10/1997
• Issued: 07/13/1999
• Est. Priority Date: 06/07/1995
• Status: Expired due to Term

• Current Assignee: Terumo BCT, Inc. (Terumo Corporation)
• Original Assignee: Cobe Cardiovascular Incorporated (LivaNova Plc)
• Inventors: Kappus, John J., Brierton, Mark J., Shouldice, David R., Toavs, Coy, Blakeslee, Jeffrey J.
• Primary Examiner(s): Weiss, John G.
• Assistant Examiner(s): O YONG, KI
• Application Number:
  US08/948,968
• Time in Patent Office: 641 Days
• Field of Search: 604/4-6, 204/157.62, 422/20
• US Class Current: 604/4.01
• CPC Class Codes: A61M 1/30 Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
• CPC Class Codes: A61M 1/303 having a reservoir for treated blood to be returned
• CPC Class Codes: A61M 1/308 Volume control, e.g. with open or flexible containers, by counting the number of pump revolutions, weighing
• CPC Class Codes: A61M 1/36222 Details related to the interface between cassette and machine
• CPC Class Codes: A61M 1/36224 with sensing means or components thereof
• CPC Class Codes: A61M 1/36225 with blood pumping means or components thereof
• CPC Class Codes: A61M 1/36226 Constructional details of cassettes, e.g. specific details on material or shape
• CPC Class Codes: A61M 1/362262 Details of incorporated reservoirs
• CPC Class Codes: A61M 1/362263 Details of incorporated filters
• CPC Class Codes: A61M 1/362265 Details of valves
• CPC Class Codes: A61M 1/362266 Means for adding solutions or substances to the blood
• CPC Class Codes: A61M 1/3624 Level detectors; Level control
• CPC Class Codes: A61M 1/3639 Blood pressure control, pressure transducers specially adapted therefor
• CPC Class Codes: A61M 1/3641 Pressure isolators
• CPC Class Codes: A61M 1/3652 using gas, e.g. air
• CPC Class Codes: A61M 1/3692 Washing or rinsing blood or blood constituents
• CPC Class Codes: A61M 1/3693 using separation based on different densities of components, e.g. centrifuging
• CPC Class Codes: A61M 1/3696 with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
• CPC Class Codes: A61M 2205/12 with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 2205/123 with incorporated reservoirs
• CPC Class Codes: A61M 2205/125 : with incorporated filters
• CPC Class Codes: A61M 2205/128 : with incorporated valves
• CPC Class Codes: A61M 2205/14 : Detection of the presence or absence of a tube, a connector or a container in an apparatus
• CPC Class Codes: A61M 2205/3382 : Upper level detectors
• CPC Class Codes: A61M 2205/3386 : Low level detectors
• CPC Class Codes: A61M 2205/505 : Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
• CPC Class Codes: B04B 2005/045 : having annular separation channels
• CPC Class Codes: B04B 5/0442 : with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
• CPC Class Codes: B04B 9/08 : Arrangement or disposition of transmission gearing for solid bowl screw centrifuges B04B1/2016; Couplings; Brakes

Abstract

An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.

Claims

1. A device for extracorporeal blood processing, comprising:

a cassette member for transferring at least one of whole blood and blood components during use, and having a plurality of separate tubing loops extending outwardly therefrom;

a plurality of separate flow control means for contacting corresponding ones of said tubing loops to control the flow of fluids therethrough during use;

at least one ultrasonic sensing means for sensing a predetermined parameter relating to said transfer of at least one of said whole blood and blood components through said cassette member during use;

a mounting means for selectively, securably and supportably receiving said cassette member in a substantially fixed position relative thereto, said mounting means being selectively moveable between first and second locations relative to said plurality of flow control means and said sensing means, wherein upon moving said mounting means from said first to said second location, said plurality of tubing loops move into an operative position relative to said corresponding plurality of flow control means, and said cassette member moves into an operative position for operation of said ultrasonic sensing means whereupon said ultrasonic sensing means provides a corresponding signal.

2. A device for extracorporeal blood processing as claimed in claim 1, said mounting means comprising:

a pivotable, spring-loaded member for engaging said cassette member, said pivotable, spring-loaded member being pivotable in said first location.

3. A device as claimed in claim 2, wherein at least one of said separate flow control means is positioned in predetermined relation relative to said cassette member, and wherein said pivotal, spring-loaded member is physically restricted from pivotal movement in said second location.

4. A device as claimed in claim 1, further comprising:

drive means for moving mounting means between said first and second locations.

5. A device as claimed in claim 4, said drive means including:

force limiting means for limiting the maximum amount of drive force providable by said drive means to said mounting means to a predetermined level.

6. A device as claimed in claim 4, further comprising:

indicator means interconnected with said drive means synchronous movement with said mounting means; and

optical sensor means for optically sensing the position of said indicating means and providing an output signal employable in controlling said drive means.

7. A device as claimed in claim 1, said cassette member further having a plurality of outwardly extending lips, and said mounting means further comprising a plurality of channel projections for receiving said plurality of lips.