Treating aneurysms by applying hardening/softening agents to hardenable/softenable substances

• US 5,921,954 A
• Filed: 07/10/1996
• Issued: 07/13/1999
• Est. Priority Date: 07/10/1996
• Status: Expired due to Fees

• Current Assignee: Lawrence G. Mohr Jr, Stuart D. Edwards
• Original Assignee: Lawrence G. Mohr Jr, Stuart D. Edwards
• Inventors: Mohr, Lawrence G. Jr., Edwards, Stuart D.
• Primary Examiner(s): Coggins, Wynn Wood
• Assistant Examiner(s): Sadula, Jennifer R.
• Application Number:
  US08/677,811
• Time in Patent Office: 1,098 Days
• Field of Search: 604/19-22, 604/48, 604/49, 604/51-53, 604/96, 606/191-194, 606/198, 623/1, 623/11, 623/12
• US Class Current: 604/508
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2017/003 Steerable
• CPC Class Codes: A61B 2018/00214 Expandable means emitting energy, e.g. by elements carried thereon
• CPC Class Codes: A61B 2018/0022 Balloons
• CPC Class Codes: A61B 2018/00261 arranged in a line
• CPC Class Codes: A61B 2018/0041 Removal of thrombosis
• CPC Class Codes: A61B 2018/00416 Treatment of aneurisms
• CPC Class Codes: A61B 2018/00797 measured by multiple temperature sensors
• CPC Class Codes: A61B 2090/3614 using optical fibre
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00

Abstract

A method and system for treating aneurysms by applying RF energy to collagen. A catheter is disposed near the aneurysm and collagen is exuded into or near the aneurysm. RF energy is applied, using the same catheter or a second catheter, to the collagen, causing the collagen to harden and cover the weak region of the blood vessel wall, and providing a base onto which epithelial cells of the blood vessel may grow. The catheter comprises an electrophysiology catheter, including a ring electrode preferably disposed to deliver between about 5 and about 30 watts of RF energy at a frequency preferably between about 450 and about 600 Megahertz, to apply sufficient energy to cause the collagen to harden while avoiding damage to surrounding tissue.

Claims

1. Apparatus for medical treatment of an aneurysm in a blood vessel of a body, said apparatus comprising:

a multi-lumen catheter having a distal and a proximal end;

a catheter tip electrode housing having a distal and a proximal end, said electrode housing proximal end being connected to said catheter distal end;

a plurality of ports located on the surface of said electrode housing, said ports being connected to a source of substantially non-translucent treatment fluid by a lumen running longitudinally through said catheter, said ports being disposed for exuding said treatment fluid in a plurality of directions from said electrode housing;

a substantially non-translucent inflatable balloon disposed on said electrode housing, said balloon being effective to expand and substantially fill said blood vessel;

a conductor running longitudinally through a lumen in said catheter from an energy source;

at least one ring electrode located in said electrode housing and connected to said conductor, said ring electrode being operative to emit between 5 watts and 30 watts of RF energy in a frequency range from 450 KHz to 600 KHz;

means for moving said balloon while said balloon and said catheter tip electrode housing are located near said aneurysm and while said balloon is at least partially inflated, said movement of said balloon being effective to buff the surface of said treatment fluid to a smooth condition.

2. Apparatus as in claim 1, wherein said treatment fluid is at least one of the following:

a collagenous fluid, a bioactive fluid, or a chemoactive fluid.

3. Apparatus as in claim 1, wherein said ring electrode is effective to emit at least one of the following:

microwave energy, or energy in a pulsed wave form.

4. Apparatus as in claim 1, wherein said movement is at least one of the following:

longitudinal along the axis of said blood vessel, rotational about the axis of said blood vessel, or a combination of longitudinal movement and rotational movement relative to the axis of said blood vessel.

5. Apparatus as in claim 1, including

a stent;

means of disposing said stent near said aneurysm.

6. A method comprising the following steps:

disposing a catheter in a blood vessel such that a catheter tip electrode housing of said catheter is located near an aneurysm;

exuding a mass of a treatment fluid from a set of ports in said catheter into or near said aneurysm;

at least partially inflating a balloon disposed on said catheter tip electrode housing;

emitting a first amount of RF energy for a first length of time effective to cause at least a portion of said treatment fluid to couple or adhere to said aneurysm;

emitting a second amount of said RF energy for a second length of time effective to harden at least a portion of said treatment fluid;

emitting a third amount of said RF energy for a third length of time effective to soften at least a portion of said treatment fluid;

moving said balloon within said blood vessel to buff the interior surface of said treatment fluid to a smooth condition; and

,

allowing said treatment fluid to cool and harden with said interior surface in said smooth condition.

7. A method as in claim 6, wherein said steps are repeated at a single location in said blood vessel to create more than one layer of smoothed and hardened treatment fluid.

8. A method as in claim 6, wherein said steps are repeated at several adjacent locations in said blood vessel to create a seamless sequence of adjacent treated areas of at least one layer each.

9. Method as in claim 6, wherein said steps are repeated more than once at each of several adjacent areas of said blood vessel to create a seamless sequence of adjacent treated areas of more than one layer each.

10. Method as in claim 6, wherein said step of exuding a treatment fluid includes exuding at least one of the following:

a collagenous fluid, a bioactive fluid, or a chemoactive fluid.

11. Method as in claim 6, wherein said steps of emitting energy include emitting at least one of the following:

microwave energy, or energy in a pulsed wave form.

12. Method as in claim 6, wherein said step of moving said balloon to buff the interior of said treatment fluid to a smooth condition includes at least one of the following:

movement longitudinal along the axis of said blood vessel, movement rotational about the axis of said blood vessel, or a combination of movement longitudinal and rotational relative to the axis of said blood vessel.

13. A method as in claim 6, including steps for

disposing a stent before said mass of treatment fluid is exuded,

wherein said step of buffing operates to conceal said stent from flow in said blood vessel.