Interlocking couplings for osmotic delivery devices

• US 5,922,353 A
• Filed: 10/08/1997
• Issued: 07/13/1999
• Est. Priority Date: 06/07/1995
• Status: Expired due to Fees

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Robinson, Urano A., Smith, Jonathan P., Pike, James B., Bourneuf, Edward V., Sharockman, John M., Magruder, Judy A., Wright, Jeremy C., Peery, John R., Cortese, Richard, Eckenhoff, deceased, James B.
• Primary Examiner(s): BROUILLETTE, D GABRIELLE
• Application Number:
  US08/947,110
• Time in Patent Office: 643 Days
• Field of Search: 424/473, 424/438, 604/890.1
• US Class Current: 424/473
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Abstract

A delivery system is disclosed for delivering a fluid-sensitive active agent such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a first wall section, a second wall section and a locking coupling therebetween. The coupled wall sections define a compartment, enclosing an active agent and an expandable driving member. Various embodiments of the locking coupling are disclosed.

Claims

1. An osmotic delivery device for dispensing an active agent to an environment of use, the delivery device comprising:

a first wall section;

a second wall section;

an interlocking coupling between the first and second wall sections, the coupled sections defining an internal compartment;

an active agent and an expandable driving member enclosed within the compartment formed by the coupled first and second wall sections; and

an exit passageway in the first wall section for delivering the active agent to the environment of use.

2. The device of claim 1, further comprising a movable partition between the active agent and the expandable driving member.

3. The device of claim 1, wherein the first wall section comprises a fluid impermeable material and the second wall section comprises an fluid permeable material.

4. The device of claim 1, wherein the interlocking coupling comprises a projection received within a depression.

5. The device of claim 4, wherein the projection and the depression define an adhesive receiving compartment therebetween.

6. The device of claim 4, wherein the projection comprises a threaded portion of the first wall section that threadingly engages with the depression that comprises a threaded portion of the second wall section.

7. The device of claim 6, wherein the threaded portion of the first and second wall sections define a compartment for receiving an adhesive therebetween.

8. The device of claim 4, wherein the projection comprises a gently sloping inserting face and a sharply sloping retaining face.