Oligonucleotide modulation of protein kinase C
First Claim
1. An oligonucleotide having up to 50 nucleotide units hybridizable with a nucleic acid encoding protein kinase C-α
- and which modulates protein kinase C-α
expression, wherein said oligonucleotide comprises a nucleotide sequence selected from the group consisting of SEQ ID NO;
1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 52, and 53.
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Accused Products
Abstract
Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. Oligonucleotides specifically hybridizable with a translation initiation site, 5'"'"'-untranslated region or 3'"'"'-untranslated region are provided. Oligonucleotides specifically hybridizable with a particular PKC isozyme or set of isozymes are also provided. In preferred embodiments, the oligonucleotides contain one or more chemical modifications. Methods of modulating PKC expression and of treating animals suffering from disease amenable to therapeutic intervention by modulating protein kinase C expression using oligonucleotides targeted to PKC are disclosed.
23 Citations
13 Claims
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1. An oligonucleotide having up to 50 nucleotide units hybridizable with a nucleic acid encoding protein kinase C-α
- and which modulates protein kinase C-α
expression, wherein said oligonucleotide comprises a nucleotide sequence selected from the group consisting of SEQ ID NO;
1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 52, and 53. - View Dependent Claims (2, 3, 4, 5, 6, 7)
- and which modulates protein kinase C-α
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8. An oligonucleotide having up to 50 nucleotide units hybridizable with a nucleic acid encoding protein kinase C-α
- and which modulates protein kinase C-α
expression, wherein said oligonucleotide comprises SEQ ID NO;
2. - View Dependent Claims (9)
- and which modulates protein kinase C-α
-
10. An oligonucleotide having up to 50 nucleotide units hybridizable with a nucleic acid encoding protein kinase C-α
- and which modulates protein kinase C-α
expression, wherein said oligonucleotide comprises SEQ ID NO;
3. - View Dependent Claims (11)
- and which modulates protein kinase C-α
-
12. An oligonucleotide having up to 50 nucleotide units hybridizable with a nucleic acid encoding protein kinase C-α
- and which modulates protein kinase C-α
expression, wherein said oligonucleotide comprises SEQ ID NO;
5. - View Dependent Claims (13)
- and which modulates protein kinase C-α
Specification