Therapeutic methods and delivery systems utilizing sex steroid precursors
First Claim
1. A kit for inhibiting the development of or treating, physical symptoms of menopause comprising a first container having therein at least one sex steroid precursor selected from the group consisting of dehydroepiandrosterone, dehydroepiandrosterone sulphate, and compounds converted in vivo to either of the foregoing and further comprising at least one additional container having therein progestin, suitable for administration to obtain and maintain DHEA serum levels within 4 to 13 micrograms per liter.
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Abstract
Sex steroid precursors such as dehydroepiandrosterone and dehydroepiandrosterone sulphate, and compounds converted in vivo to either of the foregoing, are utilized for the treatment of vaginal atrophy, hypogonadism, diminished libido, loss of collagen or connective tissues in the skin, and, in combination with an estrogen and/or progestin, for the treatment of menopause. The precursors may be formulated for percutaneous or transmucosal administration. Gels, solutions, lotions, creams, ointments and transdermal patches for the administration of these precursors are provided, as are certain pharmaceutical compositions and kits which can be used for the prevention and treatment of a wide variety of conditions related to decreased secretion of sex steroid precursors by the adrenals.
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Citations
3 Claims
- 1. A kit for inhibiting the development of or treating, physical symptoms of menopause comprising a first container having therein at least one sex steroid precursor selected from the group consisting of dehydroepiandrosterone, dehydroepiandrosterone sulphate, and compounds converted in vivo to either of the foregoing and further comprising at least one additional container having therein progestin, suitable for administration to obtain and maintain DHEA serum levels within 4 to 13 micrograms per liter.
Specification