Method and apparatus for magnetic resonance arteriography using contrast agents

• US 5,924,987 A
• Filed: 10/06/1997
• Issued: 07/20/1999
• Est. Priority Date: 10/06/1997
• Status: Expired due to Term

• Current Assignee: Martin R. Prince
• Original Assignee: Martin R. Prince
• Inventors: Prince, Martin R., Meaney, James F. M.
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): SHAW, SHAWNA JEANNINE
• Application Number:
  US08/944,426
• Time in Patent Office: 652 Days
• Field of Search: 600/410, 600/419, 600/420, 600/415, 324/306, 324/309, 324/318
• US Class Current: 600/420
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/704 Tables
• CPC Class Codes: G01R 33/5601 involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
• CPC Class Codes: G01R 33/5635 Angiography, e.g. contrast-enhanced angiography [CE-MRA] or time-of-flight angiography [TOF-MRA]
• CPC Class Codes: G01R 33/56383 involving motion of the sample as a whole, e.g. multistation MR or MR with continuous table motion

Abstract

The present invention is a technique of, and system for, imaging vascular anatomy over distance considerably greater than the maximum practical field of view of a magnetic resonance imaging system while using substantially one contrast agent injection. The technique and system of the present invention acquires image data of a plurality of image volumes which are representative of different portions of the patient'"'"'s body. The image data of each image volume includes image data which is representative of the center of k-space. The acquisition of image data which is representative of the center of k-space is correlated with a concentration of contrast agent in the artery(ies) residing in the image volume being substantially greater than the concentration of contrast agent in veins and background tissue adjacent to the artery(ies). This provides preferential enhancement of arteries relative to adjacent veins and background tissue for each acquisition, wherein each acquisition is representative of a different portion of the arterial system (e.g., abdominal aorta, femoral, popliteal, and tibial arteries).

Claims

1. A method of imaging arteries in a patient using a magnetic resonance imaging system and an administered contrast agent of substantially one injection which provides an arterial phase of contrast enhancement, wherein the arteries include a first artery which is located in a first image volume and a second artery in a second image volume, the method comprising:

positioning the patient in a first location in the imaging apparatus;

collecting magnetic resonance image data of the first image volume, including image data which is representative of a center of k-space, during the arterial phase of contrast enhancement of the first artery and while the patient is in the first location;

re-positioning the patient in the second location in the imaging apparatus; and

collecting magnetic resonance image data of the second image volume, including image data which is representative of a center of k-space, during the arterial phase of contrast enhancement of the second artery and while the patient is in the second location.

2. The method of claim 1 further including constructing an image of the first and second arteries using the image data of the first and second image volumes.

3. The method of claim 2 further including the step of administering the magnetic resonance contrast agent to the patient includes administering the contrast agent in a bolus type injection.

4. The method of claim 1 wherein the step of collecting the image data of the second image volume includes collecting image data which is representative of the center of k-space substantially at a beginning of a second imaging sequence.

5. The method of claim 4 wherein the second imaging sequence is a 3D imaging sequence.

6. The method of claim 5 wherein the step of administering the magnetic resonance contrast agent to the patient includes administering the contrast substantially throughout collection of image data of the first and second image volumes.

7. The method of claim 5 wherein the first image volume overlaps the second image volume by less than about 25%.

8. The method of claim 1 further including:

re-positioning the patient in a third location in the imaging apparatus to image a third artery;

collecting image data of the third image volume, including image data which is representative of a center of k-space, during the arterial phase of contrast enhancement of the third artery and while the patient is in the third location.

9. The method of claim 1 further including:

collecting image data of a pre-contrast data set including collecting image data before administering a substantial amount of the magnetic resonance contrast agent to the patient; and

constructing an image of the first artery by subtracting the image data of the pre-contrast data set from the image data of the first image volume.

10. The method of claim 9 further including:

collecting image data of a pre-contrast data set including collecting image data before administering a substantial amount of the magnetic resonance contrast agent to the patient; and

constructing an image of the second artery by subtracting the image data of the pre-contrast data set from the image data of the second image volume.

11. The method of claim 1 further including:

collecting image data of a pre-contrast image data set including collecting image data before administering a substantial amount of the magnetic resonance contrast agent to the patient; and

constructing an image of the artery by subtracting an image constructed using the pre-contrast image data set from an image constructed using image data of the first image volume.

12. The method of claim 1 wherein the step of collecting the image data of the first image volume includes collecting image data while a slice thickness is less than about 5 millimeters.

13. The method of claim 1 wherein the step of collecting the image data of the first image volume includes collecting image data using a coronally oriented imaging volume.

14. The method of claim 1 wherein the step of collecting the image data of the first image volume includes collecting image data while a field of view is greater than about 30 centimeters.

15. The method of claim 1 wherein the step of collecting the image data of the first image volume includes collecting a substantial portion of the center of k-space while a flip angle is between about 30°

to about 90°

, TR≦

30 milliseconds and TE≦

7 milliseconds.

16. The method of claim 1 wherein the step of collecting the image data of the first image volume includes collecting a substantial portion of the center of k-space while a flip angle is between about 30°

to about 90°

, TR≦

10 milliseconds and TE≦

3 milliseconds.

17. The method of claim 1 wherein the step of collecting the image data of the first image volume includes collecting a substantial portion of the center of k-space while a flip angle is between about 30°

to about 90°

, TR≦

5 milliseconds and TE≦

2.5 milliseconds.

18. The method of claim 1 wherein the step of collecting the image data of the first image volume includes using a 3D gradient echo pulse sequence.

19. The method of claim 18 wherein the 3D gradient echo pulse sequence is a 3D spoiled gradient echo pulse sequence.

20. The method of claim 1 wherein the first artery is an aorta.

21. The method of claim 1 wherein the second artery is an artery in at least one of a pelvis, leg or foot.

22. The method of claim 1 wherein the first artery is an artery in the leg and the second artery is an artery in a foot.

23. The method of claim 1 wherein the step of administering the contrast agent to the patient further includes administering the magnetic resonance contrast agent to the patient to provide a maximum concentration of the contrast agent in the first artery, relative to adjacent veins and background tissue, which coincides with collecting image data of the first image volume which is representative of the center of k-space.

24. The method of claim 1 further including correlating the administration of the contrast agent with the step of collecting image data of a first image volume in accordance with at least one of a delay time in a delivery system and a location of the artery.

25. A magnetic resonance imaging system for imaging arteries in a patient using an injected contrast agent of substantially one injection which provides an arterial phase of contrast enhancement, the arteries include a first artery which is located in a first image volume and a second artery which is located in a second image volume, the system comprises:

a magnetic resonance imaging apparatus,

a platform for supporting the patient in a substantially horizontal posture, the platform being moveable with respect to the imaging apparatus and between a plurality of locations, including a first location and a second location, along a longitudinal axis of the platform, wherein the platform moves at a rate sufficient to allow positioning between the first location and the second location in a time period less than the arterial phase of contrast enhancement;

imaging means for collecting magnetic resonance image data of the first image volume during the arterial phase of contrast enhancement of the first artery and while the platform is positioned at the first location, and for collecting magnetic resonance image data of the second image volume during the arterial phase of contrast enhancement of the second artery and while the platform is positioned at the second location.

26. The system of claim 25 further including means for moving the platform between a plurality of discrete locations along the longitudinal axis.

27. The system of claim 25 wherein the imaging means collects image data which is representative of a periphery of k-space after collecting image data which is representative of the center of k-space.

28. The system of claim 25 wherein the imaging means collects image data which is representative of a periphery of k-space of the first image volume after collecting image data which is representative of the center of k-space of the first image volume.

29. The system of claim 25 wherein the imaging means collects image data which is representative of a periphery of k-space of the first image volume before collecting image data which is representative of the center of k-space of the first image volume.

30. The system of claim 25 wherein the imaging means collects image data which is representative of a periphery of k-space of the second image volume after collecting image data which is representative of the center of k-space of the second image volume.

31. The system of claim 25 wherein the imaging means collects image data which is representative of a periphery of k-space of the second image volume before collecting image data which is representative of the center of k-space of the second image volume.

32. The system of claim 25 wherein the imaging means generates a data collection complete signal in response to completing collection of the image data of the first image volume and wherein the platform, in response to the data collection complete signal, automatically moves from the first location to the second location.

33. The system of claim 32 wherein the platform generates a move complete signal in response to arriving at the second location and wherein the imaging means automatically collects the image data of the second image volume in response to the move complete signal.

34. The system of claim 32 wherein an operator, in response to the data collection complete signal, moves the platform from the first location to the second location.

35. The system of claim 32 wherein the imaging means automatically collects the image data of the second image volume when the platform is positioned at the second location.

36. The system of claim 25 further including monitoring means for monitoring a concentration of the injected magnetic resonance contrast agent in a region of interest and wherein the imaging means collects image data of the first image data volume in response to an image acquisition signal.

37. The system of claim 36 further including means for generating the image acquisition signal when the magnetic resonance contrast agent in the region of interest is above a predetermined concentration.

38. The system of claim 36 wherein an operator interface generates the image acquisition signal in response to an operator input.

39. The system of claim 25 further including administration means for administering the contrast agent at a rate greater than about 0.05 millimoles/sec or at a rate greater than about 1 cc/sec.

40. The system of claim 25 wherein the imaging means further includes means for constructing an image of the first and second arteries using the image data of the first and second image volumes.

41. The system of claim 25 wherein the imaging means further includes:

means for collecting image data of a pre-contrast image data set including collecting image data before administering a substantial amount of the magnetic resonance contrast agent to the patient; and

means for constructing an image of the first artery by subtracting the image data of the pre-contrast image data set from the image data of the first image volume.

42. The system of claim 25 wherein the imaging means further includes:

means for collecting image data of a pre-contrast image data set including collecting image data before administering a substantial amount of the magnetic resonance contrast agent to the patient; and

means for constructing an image of the second artery by subtracting the image data of the pre-contrast image data set from the image data of the second image volume.

43. The system of claim 25 wherein the means for collecting the image data of the first image volume includes means for collecting image data while a slice thickness is less than 5 millimeters.

44. The system of claim 25 wherein the means for collecting the image data of the first image volume includes means for collecting image data using a coronally oriented imaging volume.

45. The system of claim 25 wherein the means for collecting the image data of the first image volume includes means for collecting image data while a field of view is greater than about 30 centimeters.

46. The system of claim 25 wherein the means for collecting the image data of the first image volume includes means for collecting image data which is representative of a substantial portion of the center of k-space while a flip angle is between about 30°

to about 70°

, TR≦

15 milliseconds and TE≦

3 milliseconds.

47. The system of claim 25 wherein the means for collecting the image data of the first image volume includes means for collecting image data using a 3D gradient echo pulse sequence.

48. The system of claim 47 wherein the 3D gradient echo pulse sequence is a 3D spoiled gradient echo pulse sequence.

49. The system of claim 25 wherein the imaging means collects the image data of the first image volume including image data which is representative of the center of k-space while the patient suspends respiration and while a concentration of the contrast agent in the artery is substantially a maximum relative to a concentration of contrast agent in adjacent veins and background tissue.

50. The system of claim 25 wherein the first image volume overlaps the second image volume by less than about 25%.

51. The system of claim 25 wherein the second artery is an artery in at least one of a pelvis, leg or foot.

52. The system of claim 25 wherein the imaging means automatically collects the image data of the second image volume when the platform is positioned at a second location.

53. A magnetic resonance imaging system for imaging arteries in a patient using an injected contrast agent of substantially one injection which provides an arterial phase of contrast enhancement, the arteries include a first artery which is located in a first image volume, a second artery which is located in a second image volume, and a third artery which is located in a third image volume, the system comprises:

a platform for supporting the patient, the platform being moveable along a horizontal axis of the platform between a first location on the longitudinal axis, a second location on the longitudinal axis, and a third location on the longitudinal axis;

an magnetic resonance imaging unit for collecting magnetic resonance image data of the first image volume, including image data which is representative of the center of k-space, during the arterial phase of contrast enhancement of the first artery and while the platform is positioned in the first location and for collecting magnetic resonance image data of the second image volume, including image data which is representative of the center of k-space, during a portion of the arterial phase of contrast enhancement of the second artery and while the platform is positioned in the second location, and for collecting magnetic resonance image data of the third image volume, including image data which is representative of the center of k-space, during a portion of the arterial phase of contrast enhancement of the third artery and while the platform is positioned in the third location.

54. The system of claim 53 further including platform moving means for automatically moving the platform between the first, second and third locations.

55. The system of claim 54 wherein the imaging unit generates a data collection complete signal in response to completing collection of the image data of the first image volume, and wherein the platform moving means, in response to the data collection complete signal, automatically moves the platform from the first location to the second location.

56. The system of claim 54 wherein the imaging unit generates a data collection complete signal in response to completing collection of the image data of the second image volume, and wherein the platform moving means, in response to the data collection complete signal, automatically moves the platform from the second location to the third location, wherein the platform moving means generates a move complete signal in response to arriving at the third location and wherein the imaging unit automatically collects the image data of the third image volume in response to the move complete signal.

57. The system of claim 53 wherein the imaging unit constructs an image of the first, second and third arteries using the image data of the first, second and third image volumes.

58. The system of claim 53 wherein the first image volume overlaps the second image volume by less than about 25%.

59. The system of claim 58 wherein the second image volume overlaps the third image volume by less than about 25%.

60. A method of imaging arteries in a patient using a magnetic resonance imaging system and using an injected magnetic resonance contrast agent of substantially one injection, wherein the arteries include a first artery which is located in a first image volume and a second artery which is located in a second image volume, the method comprising:

positioning the patient in a first location to define a first field of view which encompasses the first artery;

collecting magnetic resonance image data of the first image volume, including image data which is representative of a center of k-space, during the arterial phase of contrast enhancement of the first artery and while the patient is in first location;

positioning the patient in a second location to define a second field of view which encompasses the second artery; and

collecting magnetic resonance image data of the second image volume, including collecting image data which is representative of a center of k-space, during the arterial phase of contrast enhancement of the second artery and while the patient is in the second location; and

constructing an image of the first artery using the image data of the first image volume and an image of the second artery using the image data of the second image volume.

61. The method of claim 60 wherein the step of collecting the image data of the second image volume includes collecting image data which is representative of the center of k-space substantially at a beginning of a second imaging sequence.

62. The method of claim 60 further including injecting the magnetic resonance contrast agent to the patient substantially throughout the step of collecting image data of the first image volume.

63. The method of claim 60 wherein the first image volume overlaps the second image volume by less than about 25%.

64. The method of claim 60 further including the steps of:

positioning the patient in a third location to define a third field of view which encompasses a third artery; and

collecting image data of a third image volume wherein the step of collecting image data of the third image volume includes collecting image data which is representative of a center of k-space during a portion of the arterial phase of contrast enhancement of the third artery.

65. The method of claim 64 wherein the first, second and third image volumes overlap by less than about 25%.

66. The method of claim 60 wherein the step of collecting the image data of the first image volume includes using a 3D gradient echo pulse sequence.

67. The method of claim 60 further including:

collecting image data of a pre-contrast data set including collecting image data before administering a substantial amount of the magnetic resonance contrast agent to the patient; and

constructing an image of the first artery by subtracting the image data of the pre-contrast data set from the image data of the first image volume.

68. The method of claim 67 further including:

collecting image data of a pre-contrast data set including collecting image data before administering a substantial amount of the magnetic resonance contrast agent to the patient; and

constructing an image of the second artery by subtracting the image data of the pre-contrast data set from the image data of the second image volume.

69. The method of claim 60 further including:

collecting image data of a pre-contrast image data set including collecting image data before administering a substantial amount of the magnetic resonance contrast agent to the patient; and

constructing an image of the artery by subtracting an image constructed using the pre-contrast image data set from an image constructed using image data of the first image volume.

70. A magnetic resonance imaging system for imaging arteries in a patient using an injected contrast agent of substantially one injection which provides an arterial phase of contrast enhancement, wherein the arteries include a first artery which is located in a first image volume and a second artery which is located in a second image volume, the system comprises:

a platform for supporting the patient, the platform being moveable between a plurality of locations including a first location which defines a first field of view encompassing the first artery and a second location which defines a second field of view encompassing the second artery, wherein the platform moves at a rate sufficient to allow positioning between the first location and the second location in a time period less than the arterial phase of contrast enhancement; and

a magnetic resonance imaging unit for collecting magnetic resonance image data of the first image volume during a portion of the arterial phase of contrast enhancement of the first artery and while the platform is positioned at the first location, and for collecting magnetic resonance image data of the second image volume during a portion of the arterial phase of contrast enhancement of the second artery and while the platform is positioned at the second location.

71. The system of claim 70 wherein platform automatically moves from the first location to the second location after the imaging means collects the image data of the first image volume.

72. The system of claim 71 wherein the magnetic resonance imaging system generates a move complete signal in response to arriving at the second location and wherein the imaging means, in response to a data collect signal, collects the image data of the second image volume in response to the move complete signal.

73. The system of claim 72 wherein an operator interface generates the data collect signal in response to an operator input.

74. The system of claim 71 wherein the imaging means automatically collects the image data of the second image volume when the platform is positioned at the second location.

75. The system of claim 70 further including monitoring means for monitoring a concentration of the injected magnetic resonance contrast agent in a region of interest and wherein the imaging means collects image data of the first image data volume in response to an image acquisition signal.

76. The system of claim 75 further including means for generating the image acquisition signal when the magnetic resonance contrast agent in the region of interest is above a predetermined concentration.

77. The system of claim 75 wherein an operator interface generates the image acquisition signal in response to an operator input.