Systems and methods for drug delivery including treating thrombosis by driving a drug or lytic agent through the thrombus by pressure

• US 5,925,016 A
• Filed: 09/27/1995
• Issued: 07/20/1999
• Est. Priority Date: 09/27/1995
• Status: Expired due to Fees

• Current Assignee: Medtronic Ave Incorporated (Medtronic Plc)
• Original Assignee: XRT Corp. (Medtronic Plc)
• Inventors: Chornenky, Victor I., Forman, Michael R.
• Primary Examiner(s): Coggins, Wynn Wood
• Assistant Examiner(s): Gring, N. Kent
• Application Number:
  US08/534,856
• Time in Patent Office: 1,392 Days
• Field of Search: 604/53, 604/27, 604/28, 604/101, 604/102, 604/35, 604/43, 604/96, 604/95, 604/19
• US Class Current: 604/96.01
• CPC Class Codes: A61M 2025/0047 the inner layer having a higher lubricity
• CPC Class Codes: A61M 2025/09008 having a balloon
• CPC Class Codes: A61M 2025/09083 having a coil around a core
• CPC Class Codes: A61M 2025/1052 for temporarily occluding a vessel for isolating a sector
• CPC Class Codes: A61M 2205/36 related to heating or cooling
• CPC Class Codes: A61M 25/007 Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
• CPC Class Codes: A61M 25/09 Guide wires
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 25/1011 Multiple balloon catheters

Abstract

Systems and methods for treating thrombosis by driving the drugs or lytic agents through the thrombus by pressure, are disclosed. The system preferably comprises a guide catheter with an occlusion balloon for isolating the region proximal to the thrombus, a guide wire with an occlusion balloon for isolating the region distal to the thrombus and an infusion catheter for delivering drugs or other agents into the region distal to the thrombus under pressure. A lumen of the guide catheter is preferably provided to evacuate material proximal to the thrombus, decreasing the pressure in the proximal to the thrombus. The lumen can be coupled to a thrombus filter to remove thrombolytic material from the drug or lytic agent evacuated from the proximal region. The filtered drug or lytic agent can then be redelivered into the distal region. Recycling of the drug or lytic agent in this manner decreases the costs of the procedure. The systems and methods of the invention can be used to treat other blockages in lumens or vessels in the body or to deliver drugs or other agents to lumens, vessels or cavities within the body, as well.

Claims

1. A system for treating a blockage in a lumen, vessel or cavity comprising:

means for delivering a drug or other agent to a first region proximate the blockage,

means for forcing the drug or other agent from the first region through the thrombus, comprising a pump in fluid communication with the first region which delivers drugs or other agents into the first region under pressure;

means for occluding the region; and

a filter coupled to the means for delivering such that filtered material comprising filtered drug or other agent is delivered to the first region.

2. A system for treating thrombosis comprising:

at least one inflation/deflation unit;

a first occlusion balloon coupled to the inflation/deflation unit, such that the first occlusion balloon can isolate a region distal to a thrombus;

a second occlusion balloon coupled to the inflation/deflation unit, such that the second occlusion balloon can isolate a second region proximal to the thrombus;

a pump;

a first lumen coupled to the pump and the first region, wherein a drug or lytic agent can be infused into the first region through the first lumen under pressure by the pump, to force the drug or other agent through the thrombus;

a second lumen coupled to the pump and the second region wherein the material can be evacuated from the second region; and

a filter between the second lumen and the pump, such that material evacuated from the second region is filtered prior to infusion into the first region through the first lumen.

3. The system of claim 2, further comprising a guide catheter, wherein the first occlusion balloon is part of the guide catheter.

4. The system of claim 2, further comprising an infusion catheter, wherein the first occlusion balloon is part of the infusion catheter.

5. The system of claim 2, further comprising an infusion catheter, wherein the first lumen is part of the infusion catheter.

6. The system of claim 2, further comprising a guide wire, wherein the first lumen is part of the guide wire.

7. The system of claim 2, further comprising an infusion catheter, wherein the second occlusion balloon is coupled to the infusion catheter.

8. The system of claim 2, further comprising a guide wire, wherein the second occlusion balloon is coupled to the guide wire.