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Therapeutic use of multilamellar liposomal prostaglandin formulations

  • US 5,925,375 A
  • Filed: 11/03/1994
  • Issued: 07/20/1999
  • Est. Priority Date: 05/22/1987
  • Status: Expired due to Fees
First Claim
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1. A method of treating an animal afflicted with a cell activation and adhesion, inflammation or toxemic disorder which comprises administering to the animal a composition comprising a pharmaceutically acceptable carrier and a multilamellar liposome comprising:

  • (i) a prostaglandin;

    (ii) multiple bilayers comprising an amphipathic phospholipid; and

    , (iii) multiple aqueous compartments comprising a release-inhibiting citric acid buffer, wherein the phospholipid consists essentially of a phospholipid having saturated acyl chains and wherein an anti-disorder effective amount of the prostaglandin comprising from about 10-12 g to about 10-3 g of the prostaglandin per kg of the animal'"'"'s body weight is administered per dose of the composition.

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