Therapeutic use of multilamellar liposomal prostaglandin formulations
First Claim
1. A method of treating an animal afflicted with a cell activation and adhesion, inflammation or toxemic disorder which comprises administering to the animal a composition comprising a pharmaceutically acceptable carrier and a multilamellar liposome comprising:
- (i) a prostaglandin;
(ii) multiple bilayers comprising an amphipathic phospholipid; and
, (iii) multiple aqueous compartments comprising a release-inhibiting citric acid buffer, wherein the phospholipid consists essentially of a phospholipid having saturated acyl chains and wherein an anti-disorder effective amount of the prostaglandin comprising from about 10-12 g to about 10-3 g of the prostaglandin per kg of the animal'"'"'s body weight is administered per dose of the composition.
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Abstract
This invention provides a multilamellar liposome containing an arachidonic acid metabolite, two or more lipid-containing bilayers and two or more aqueous compartments containing a release-inhibiting buffer. Preferred arachidonic acid metabolites are the prostaglandins, particularly PGE1. The liposomal formulations can be used to treat animals, particularly humans, for diseases, disorders or conditions which can be ameliorated by prostaglandins, e.g., disorders characterized by cellular activation and adhesion, inflammation and/or toxemia.
49 Citations
19 Claims
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1. A method of treating an animal afflicted with a cell activation and adhesion, inflammation or toxemic disorder which comprises administering to the animal a composition comprising a pharmaceutically acceptable carrier and a multilamellar liposome comprising:
- (i) a prostaglandin;
(ii) multiple bilayers comprising an amphipathic phospholipid; and
, (iii) multiple aqueous compartments comprising a release-inhibiting citric acid buffer, wherein the phospholipid consists essentially of a phospholipid having saturated acyl chains and wherein an anti-disorder effective amount of the prostaglandin comprising from about 10-12 g to about 10-3 g of the prostaglandin per kg of the animal'"'"'s body weight is administered per dose of the composition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
- (i) a prostaglandin;
Specification