Remotely programmable matrices with memories
First Claim
1. A combination of a matrix with memory, comprising:
- (A) a recording device, comprising a data storage unit; and
(B) a matrix material, wherein;
the matrix material is comprised of particles of a size such that at least one dimension is no more than 100 mm;
the recording device is in contact with the matrix or in a solution that is in contact with the matrix;
the data storage unit comprises an optical recording medium having a plurality of unique recording locations therein; and
each of the plurality of unique recording locations is uniquely addressable for storing a plurality of the data points.
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Accused Products
Abstract
Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The data storage units are preferably non-volatile antifuse memories. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, chemical modification and other uses.
193 Citations
26 Claims
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1. A combination of a matrix with memory, comprising:
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(A) a recording device, comprising a data storage unit; and (B) a matrix material, wherein; the matrix material is comprised of particles of a size such that at least one dimension is no more than 100 mm; the recording device is in contact with the matrix or in a solution that is in contact with the matrix; the data storage unit comprises an optical recording medium having a plurality of unique recording locations therein; and each of the plurality of unique recording locations is uniquely addressable for storing a plurality of the data points. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 16, 17, 24, 25)
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12. A combination of a matrix with memory, comprising:
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(A) a recording device, comprising an optical recording medium; (B) a matrix material; (C) biological particles and/or molecules in proximity to or linked to the matrix material, wherein; the recording device comprises an optical recording medium and is of a size of about 10 mm3 or less; the matrix material is in the form of a container; and the recording device is in contact with the matrix or in a solution that is in contact with the matrix and comprises data regarding the identity of or synthesis of the molecules or biological particles. - View Dependent Claims (13, 15, 22, 23, 26)
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14. A combination of a matrix with memory, comprising:
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(A) a recording device, comprising an optical recording medium; and (B) a matrix material, wherein; the recording device comprises an optical recording medium; and the matrix material is in the form of a microtiter plate, comprising a plurality of recording devices.
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18. A combination of a matrix with memory, comprising:
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(A) a recording device, comprising an optical recording medium; and (B) a matrix material in the form of a container; (C) a biological particle or molecule in a mixture in or linked directly or indirectly to the surface of the container, wherein; the matrix material is in the form of a container used for chemical syntheses; the optical recording medium comprises information that identifies the biological particle or molecule; and the recording device is in contact with the matrix or in a solution that is in contact with the matrix. - View Dependent Claims (19, 20, 21)
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Specification