Liquid embolic agents
First Claim
Patent Images
1. An occludant precursor composition for forming an occlusion mass upon introduction of the precursor into a mammalian body comprising a solution of:
- a.) partially hydrolyzed polyvinylacetate,b.) a pharmaceutically acceptable solvent, andc.) a soluble radio-opaque material.
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Abstract
This relates to a composition of matter comprising partially hydrolyzed polyvinyl acetate solutions suitable for use as embolic agent precursors. In addition, a procedure for introducing the solutions into the human body to form precipitated embolic occlusion masses is shown. Finally, a procedure for treatment of hepatic tumors using portal vein embolism is described.
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Citations
48 Claims
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1. An occludant precursor composition for forming an occlusion mass upon introduction of the precursor into a mammalian body comprising a solution of:
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a.) partially hydrolyzed polyvinylacetate, b.) a pharmaceutically acceptable solvent, and c.) a soluble radio-opaque material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for occluding a selected site in a mammalian body comprising the steps of:
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a.) introducing to said selected site an occludant precursor composition for forming an occlusion mass, said precursor comprising a solution of; i) partially hydrolyzed polyvinylacetate, and ii.) a pharmaceutically acceptable solvent, iii.) a soluble radio-opaque material, and b.) releasing said occludant precursor composition at said selected site to form said occlusion mass. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. An occludant precursor composition for forming an occlusion mass upon introduction of the precursor into a mammalian body comprising a solution of:
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a.) partially hydrolyzed polyvinylacetate, and b.) a pharmaceutically acceptable solvent comprising an aqueous ethanolic solution containing 30 to 55% (vol) ethanol. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36)
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37. A method for occluding a selected site in a mammalian body comprising the steps of:
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a.) introducing to said selected site an occludant precursor composition for forming an occlusion mass, said precursor comprising a solution of; i) partially hydrolyzed polyvinylacetate, and ii.) a pharmaceutically acceptable solvent comprising an aqueous ethanolic solution containing 30 to 55% (vol) ethanol, and b.) releasing said occludant precursor composition to form said occlusion mass. - View Dependent Claims (38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48)
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Specification