System for locating and detecting a source of photon emissions

• US 5,928,150 A
• Filed: 10/04/1997
• Issued: 07/27/1999
• Est. Priority Date: 10/04/1997
• Status: Expired due to Term

• Current Assignee: Devicor Medical Products Incorporated (Danaher Corporation)
• Original Assignee: Neoprobe Corporation
• Inventors: Call, John D.
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US08/944,078
• Time in Patent Office: 661 Days
• Field of Search: 600/431, 600/436, 600/407, 250/336.1, 250/363.01, 250/370.01, 250/370.07, 250/370.13
• US Class Current: 600/436
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: G01T 1/161 Applications in the field of nuclear medicine, e.g. in vivo counting apparatus for radiation diagnosis A61B6/00

Abstract

System for detecting emissions from a radiopharmaceutical injected within a lymph duct wherein a hand-held probe is utilized. When employed to locate sentinel lymph nodes, supplementary features are provided including a function for treating validated photon event pulses to determine count rate level signals. A function for count rate based ranging as well as an adjustable thresholding feature are also present. A post-threshold amplification circuit develops full-scale aural and visual outputs.

Claims

1. A system for detecting and locating a source of photon emissions emanating from tissue within a body, comprising:

a hand manipular probe having a housing, a crystal detector forwardly disposed within said housing responsive to said emissions impinging thereon to provide corresponding detector outputs, and a signal treatment circuit within said housing responsive to said detector outputs to provide count outputs at an output;

a control assembly located remotely from said probe, having an input network for receiving and evaluating said count outputs to derive photon count signals, a converter network responsive to said photon count signals for deriving a rate output level signal corresponding with the frequency of said photon count signals, a threshold network responsive to said rate output level signal to apply a select threshold level value thereto corresponding with a value of the rate of occurrence of said count signals to derive an adjusted count rate signal, a post thresholding amplification network responsive to said adjusted count rate signal and having a gain corresponding with said threshold level value for amplifying said adjusted count rate signal to provide an amplified count rate signal at levels within a predetermined output dynamic range, and an aural cuing network having an aurally perceptive frequency output range corresponding with said predetermined output dynamic range and responsive to said amplified output signal to provide an aurally perceptive cuing output; and

transmission means connected with said probe for conveying said count outputs to said control assembly.

2. The system of claim 1 in which:

said converter network derives said rate output level signal as a voltage of given polarity within a dynamic range of voltages extending between minimum and maximum voltage values;

said threshold network includes a summing stage with a summing input for receiving said rate output level signal and a threshold signal corresponding with said threshold level of polarity opposite said given polarity in summing relationship to derive said adjusted rate signal as voltage values within said dynamic range.

3. The system of claim 2 in which said threshold network includes a threshold voltage source and a variable resistor component electrically coupled therewith and manually actuable to provide said threshold signal.

4. The system of claim 1 in which said control assembly threshold network threshold signal is variable to effect derivation of said threshold signal in correspondence with threshold values falling within a predetermined range extending to a maximum threshold value representing a first percentage of said dynamic range.

5. The system of claim 4 in which said first percentage is about 80%.

6. The system of claim 4 in which said predetermined threshold range extends from a minimum threshold value representing a second percentage of said dynamic range less than said first percentage.

7. The system of claim 6 in which said second percentage is about 5%.

8. The system of claim 1 in which:

said threshold network derives said adjusted rate signal as voltage values within a dynamic range of voltage values remaining after application of a threshold voltage value; and

said post thresholding amplification network includes an amplification stage and a post threshold variable resistor component coupled in gain defining relationship with said amplification stage.

9. The system of claim 1 in which:

said converter network derives said rate output level signal as a voltage of given polarity within a dynamic range of voltage levels extending between minimum and maximum voltage values;

said threshold network includes a threshold voltage source of polarity opposite said given polarity, a threshold variable resistor component coupled with said source and adjustably actuable to provide a threshold signal corresponding with a selected said threshold level, and a summing stage with a summing input for receiving and summing said rate output level signal and said threshold signal to derive said adjusted rate signal as voltage values remaining subsequent to said summing stage derivation;

said post thresholding amplification network includes an amplification stage and a post threshold variable resistor component coupled in gain defining relationship with said amplification stage and adjustably actuable in correspondence with said threshold variable resistor component actuator to derive said amplified current rate signal.

10. The system of claim 9 in which said threshold variable resistor component and said post threshold variable resistor component are ganged together mechanically actuated potentiometers.

11. The system of claim 9 in which:

said threshold variable resistor component and said post threshold variable resistor component are switch actuated electronic variable resistors having commonly coupled first and second switching inputs, responsive to respectively applied first and second switching conditions to effect a common variable resistor component actuation; and

said probe includes first and second probe switches hand actuable to derive respective said first and second switching conditions.

12. The system of claim 1 in which:

said converter network derives said rate output level signal as voltages within a converter dynamic range of voltages; and

said control assembly includes a ranging network having a ranging amplification stage with at least two gain orientations selectable in correspondence with predetermined ranges of frequencies of occurrence of said photon count signals and responsive to said rate output level signal at a selected said gain orientation for providing a substantially full scale dynamic range capability for a said rate output level signal derived in correspondence with a said selected gain orientation.

13. The system of claim 1 in which:

said photon count signals are present as pulses exhibiting substantially constant pulse width; and

said converter network comprises an R-C integrating stage having a time constant of about one second.

14. The system of claim 1 in which said control assembly includes a dynamic bar graph comprised of a linear array of light emitting devices and a driver circuit responsive to said amplified output signal to energize a number of said light emitting devices corresponding with the amplitude thereof.

15. A system for detecting and locating a source of photon emissions emanating from tissue within a body, comprising:

a hand manipular probe having a housing, a crystal detector forwardly disposed within said housing and responsive to said emissions impinging thereon to provide detector outputs, and a signal treatment circuit responsive to said detector outputs to provide count outputs at an output;

a control assembly having an input network for receiving and evaluating said count outputs to derive photon count signals as pulses exhibiting a substantially constant pulse width, a frequency to voltage converter responsive to said photon count signals for deriving a rate output voltage signal having voltage values within a converter dynamic range of voltages, a ranging network including a ranging amplifier having at least two range designated gain orientations selectable in correspondence with at least two predetermined ranges of rates of occurrence of said photon count signals and responsive to said rate output voltage signal occurring at a selected said gain orientation to provide said rate output voltage signal at substantially full scale range with respect to said converter dynamic range of voltages as a ranged rate output voltage signal of given polarity, a threshold circuit having a summing stage, and a threshold signal network including a threshold variable resistor component actuable to derive a select threshold voltage of polarity opposite said given polarity and corresponding with a threshold percentage of said ranged rate output signal full scale range, said summing stage summing said select threshold voltage and said ranged rate output signal to derive an adjusted count rate signal, an aural cuing network having a frequency output range and responsive to an amplified output signal to generate an aurally perceptive output at a pitch within said frequency output range corresponding therewith, and a post threshold amplification network responsive to said adjusted count rate signal, including an amplification stage and a post threshold variable resistor component coupled in gain defining relationship with said amplification stage and actuable in correspondence with the said actuation of said threshold variable resistor component to derive said amplified output signal at full scale with respect to said frequency output range.

16. The system of claim 15 in which said threshold variable resistor component and said post threshold variable resistor component are ganged together mechanically actuated potentiometers.

17. The system of claim 15 in which:

said threshold variable resistor component and said post threshold variable resistor component are switch actuated electronic variable resistors having commonly coupled first and second switching inputs, responsive to respectively applied first and second switching conditions to effect a common variable resistor component actuation; and

said probe includes first and second probe switches hand actuable to derive respective said first and second switching conditions.

18. The system of claim 15 in which said threshold percentage is selectable within a range of percentages extending from a minimum threshold percentage to a maximum threshold percentage.

19. The system of claim 18 in which said minimum threshold percentage is about 5%.

20. The system of claim 18 in which said maximum threshold percentage is about 80%.

21. The system of claim 15 in which said control assembly includes a dynamic bar graph comprised of a linear array of light emitting devices and a driver circuit responsive to said amplified output signal to energize a number of said light emitting devices corresponding with the amplitude thereof.