Dose setting device

• US 5,928,201 A
• Filed: 06/19/1997
• Issued: 07/27/1999
• Est. Priority Date: 07/05/1996
• Status: Expired due to Fees

• Current Assignee: Novo Nordisk A/S
• Original Assignee: Novo Nordisk A/S
• Inventors: Poulsen, Jens Ulrik, Christensen, Lars Hofmann, Ljunggreen, Henrik
• Primary Examiner(s): Stright, Jr., Ronald
• Assistant Examiner(s): NGUYEN, ANH TUAN TUONG
• Application Number:
  US08/878,955
• Time in Patent Office: 768 Days
• Field of Search: 604/151, 604/152, 604/154, 604/207, 604/208, 604/67, 604/235, 128/DIG. 1
• US Class Current: 604/208
• CPC Class Codes: A61M 2005/31588 electrically driven
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 5/14546 Front-loading type injectors
• CPC Class Codes: A61M 5/14566 with a replaceable reservoir for receiving a piston rod of the pump
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/31525 Dosing burettes, pipettes B01L3/02
• CPC Class Codes: A61M 5/31546 Electrically operated dose setting, e.g. input via touch screen or plus/minus buttons
• CPC Class Codes: Y10S 128/01 Motorized syringe

Abstract

The present invention relates to a drug delivery device wherein a dose to be apportioned from a cartridge is set by changing the relative position of co-operating dose setting elements (3, 5) and is injected by pressing a button (5) until this button abuts a stop (6). By operation of count up (7) or count down (8) buttons the dose is set and read into an electronic circuit (9) comprising a microprocessor and the dose setting movement of the dose setting elements relative to each other is performed by a motor (11) controlled by the circuit in accordance with the read in dose. The set dose is shown on a display (10). The motor (11) is further controlled to perform certain movements of the piston rod (3) so as retraction of this rod when a cartridge (1) is going to be changed an advancing of the piston rod to abutment with the piston (2) after the cartridge has been changed and further to advance this piston to expel air from the cartridge.

Claims

1. A drug delivery device for dispensing set doses from a cartridge, comprising:

cooperating dose-setting elements, the relative position of which can be changed to set a dose;

a delivery button which is moved away from an original position relative to the device in response to setting of a dose and which is exposed such that the user of the device may manually press it back toward said original position, and wherein pressing the delivery button toward said original position causes the set dose to be injected;

an electronic circuit into which a value representing a set dose may be read and stored; and

an electromechanical device which is controlled by the electronic circuit to move the dose setting elements relative to one another in accordance with the stored dose value, thereby to set the desired dose, wherein the set dose may thereafter be administered manually by pressing said delivery button.

2. A device according to claim 1, wherein said electronic circuit comprises a microprocessor.

3. A device according to claim 1, further comprising a pair of dose-setting switches, wherein operation of said switches causes a stepwise increase or decrease in dose value to be read into said electronic circuit.

4. A device according to claim 1, wherein said electronic circuit includes means for determining the number of units of drug left in the cartridge and for setting such number as an upper limit for the value which can be read into said electronic circuit to set a dose.

5. A device according to claim 1, wherein said electronic circuit has an output representing the size of the set dose, and further comprising an output device such as an electronic display or speech synthesizer coupled to receive said output for communicating the size of the set dose to the user of the device.

6. A device according to claim 5, further comprising means to monitor the relative position of dose-setting elements, wherein said electronic circuit compares the dose represented by said relative position with the dose communicated to the user and includes means to control the electromechanical device to move said dose-setting elements to a relative position corresponding to the dose communicated to the user in the event of any discrepancy.

7. A device according to claim 5, further comprising a position reader for sensing the mechanical movements of the dose-setting elements, wherein said electromechanical device comprises a motor, wherein said electronic circuit controls said motor in accordance with the stored dose, and wherein the output to said output device is in response to said position reader.

8. A device according to claim 1, wherein the button is coupled to a dose-setting element so that it moves, when a dose is set, a distance corresponding to the set dose.

9. A device according to claim 1, further comprising a button switch which is actuated when said button is pressed to its original position.

10. A device according to claim 1, further comprising a cartridge holder which may be open or closed, and a cartridge holder switch, coupled to the electronic circuit, which detects whether a cartridge holder is open or closed.

11. A device according to claim 10, further comprising a piston rod which may be moved between a retracted position and various extended positions, and a button switch which is actuated when said button is pressed to its original position, wherein said electromechanical device comprises a motor, and wherein said electronic circuit is programmed to activate said motor, in response to said cartridge holder switch detecting that said cartridge holder is open and said button switch detecting that said button is in its original position, to move said piston rod to said retracted position.

12. A device according to claim 11, wherein said electronic circuit further comprises means for sensing the power consumption of said motor, and wherein, responsive to a signal from said cartridge holder switch indicating that said cartridge holder has been moved from an open to a closed position and a signal from said injection button switch that said injection button is in its original position, said electronic circuit activates said motor to advance said piston rod until sensing a predetermined increase in power consumption by said motor, indicating that said piston rod abuts a piston in the cartridge.

13. A device according to claim 12, further comprising an air shot button, and wherein said electronic circuit, when said air shot button is pressed and said injection button switch indicates that said injection button is in its original position, activates said motor to advance said piston rod until its power consumption exceeds a predetermined value, indicating that liquid and not air is being pressed out of the cartridge.

14. A device according to claim 13, wherein said electronic circuit monitors its respective input signals and alerts the user in the event of a signal malfunction.