Microneedle with isotropically etched tip, and method of fabricating such a device

• US 5,928,207 A
• Filed: 06/30/1997
• Issued: 07/27/1999
• Est. Priority Date: 06/30/1997
• Status: Expired due to Term

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Pisano, Albert P., Lebouitz, Kyle S.
• Primary Examiner(s): Coggins, Wynn Wood
• Assistant Examiner(s): GRING, NOELLE K
• Application Number:
  US08/884,867
• Time in Patent Office: 757 Days
• Field of Search: 604/272, 604/273, 604/274, 604/264, 606/222, 606/223, 606/224, 606/181
• US Class Current: 604/272
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/296 for electromyography [EMG]
• CPC Class Codes: A61B 5/6848 Needles
• CPC Class Codes: A61B 5/685 Microneedles

Abstract

A microneedle includes an elongated body with a top surface, a bottom surface, a first side wall between the top surface and the bottom surface, and a second side wall between the top surface and the bottom surface. An end is defined by the bottom surface converging into a tip, an isotropically etched portion of the first side wall converging into the tip, and an isotropically etched portion of the second side wall converging into the tip. The elongated body is less than approximately 700 μm wide and less than approximately 200 μm thick. The elongated body may incorporate a fluid channel. The elongated body may be formed of silicon that is not doped with Boron. In such a configuration, integrated circuitry or a micromachined device, such as a heater or pump may also be formed on the device. A number of novel processing techniques are associated with the fabrication of the device. The device may be formed by relying solely on isotropic etching. Alternately, a combination of isotropic and anisotropic etching may be used. Unlike prior art micromachined devices, the disclosed device may be processed at relatively low temperatures below 1100° C. and without using the carcinogen ethylenediamin pyrocatechol.

Claims

1. A method of fabricating a lancet, said method comprising the steps of:

providing a semiconductor substrate;

defining a mask configuration on said semiconductor substrate, said mask configuration corresponding to the shape of a lancet for lancing tissue; and

applying an isotropic etchant to said semiconductor substrate, said mask configuration causing said isotropic etchant to etch said semiconductor substrate to define a lancet with isotropically etched sidewalls converging into a tip.

2. The method of claim 1 wherein said providing step includes the step of providing a silicon on-insulator (SOI) wafer as said semiconductor substrate.

3. The method of claim 1 wherein said applying step is performed at temperatures below approximately 1100°

C.

4. The method of claim 1 wherein said applying step results in a lancet that is between approximately 100 μ

m wide and 700 μ

m wide.

5. The method of claim 1 wherein said applying step results in a lancet that is between approximately 100 μ

m thick and 200 μ

m thick.

6. A method of fabricating a lancet, said method comprising the steps of:

providing a semiconductor substrate;

defining a mask configuration on said semiconductor substrate, said mask configuration corresponding to the shape of a lancet for lancing tissue; and

applying an isotropic etchant to said semiconductor substrate, said mask configuration causing said isotropic etchant to etch said semiconductor substrate to define a lancet with isotropically etched sidewalls converging into a tip, wherein said applying step is performed without the use of ethylenediamine pyrocatechol.

7. A method of fabricating a needle, said method comprising the steps of:

providing a semiconductor substrate;

defining a mask configuration on said semiconductor substrate, said mask configuration corresponding to the shape of a needle;

applying an isotropic etchant to said semiconductor substrate, said mask configuration causing said isotropic etchant to etch said semiconductor substrate to define a needle with isotropically etched sidewalls converging into a tip, wherein said applying step is performed without the use of ethylenediamine pyrocatechol; and

fabricating a cap on said needle to establish a channel between said cap and said semiconductor substrate.