Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas

• US 5,928,226 A
• Filed: 10/06/1997
• Issued: 07/27/1999
• Est. Priority Date: 03/13/1990
• Status: Expired due to Term

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Sepetka, Ivan, Guglielmi, Guido
• Primary Examiner(s): COHEN, LEE S
• Application Number:
  US08/944,581
• Time in Patent Office: 659 Days
• Field of Search: 606/32, 606/41, 606/49, 606/28, 606/108, 606/191, 606/200, 600/569, 600/585, 604/104, 607/122, 623/1, 623/12
• US Class Current: 606/32
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12113 within an aneurysm
• CPC Class Codes: A61B 17/1214 Coils or wires
• CPC Class Codes: A61B 17/12145 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/1215 comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2017/00292 mounted on or guided by flexible, e.g. catheter-like, means
• CPC Class Codes: A61B 2017/12063 electrolytically detachable
• CPC Class Codes: A61B 2017/22038 with a guide wire
• CPC Class Codes: A61B 2018/00678 upper
• CPC Class Codes: A61B 2018/00761 Duration
• CPC Class Codes: A61B 2018/00875 Resistance or impedance
• CPC Class Codes: A61B 2018/00886 Duration
• CPC Class Codes: A61B 2018/1226 powered by a battery
• CPC Class Codes: A61B 2018/1253 monopolar
• CPC Class Codes: A61B 2018/126 bipolar
• CPC Class Codes: A61B 2018/1266 with DC current output
• CPC Class Codes: A61B 2018/1435 Spiral
• CPC Class Codes: A61B 2018/1495 Electrodes being detachable from a support structure
• CPC Class Codes: A61B 2090/3966 Radiopaque markers visible in an X-ray image
• CPC Class Codes: A61B 90/39 : Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61M 2025/0042 : Microcatheters, cannula or the like having outside diameters around 1 mm or less
• CPC Class Codes: A61M 2025/09175 : having specific characteristics at the distal tip
• CPC Class Codes: A61M 25/09 : Guide wires

Abstract

An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire. Electrothrombosis is facilitate by placing the ground electrode on the distal end of the microcatheter and flowing current between the microcatheter electrode and the tip.

Claims

1. An apparatus for use in electrothrombosis in combination with a microcatheter the apparatus comprising:

a core wire having a main body with a distal portion and a detachable coil coupled to said main body via said distal portion and comprised of material not susceptible to electrolytic disintegration, said detachable coil containing no internal reinforcement and being for insertion within a body cavity;

wherein said distal portion is susceptible to electrolytic disintegration so that on the application of current to the apparatus when said detachable coil is disposed in the cavity, electrothrombosis can be performed and at least one portion of said distal portion electrolytically disintegrated to detach said detachable coil from said main body.

2. The apparatus of claim 1 wherein said distal portion is exposed stainless steel comprising a stainless steel coil connected at its proximal end to said core wire and connected at its distal end to said detachable coil, and wherein said distal portion further comprises a threadlike extension of the main body of the core wire extending concentrically within said stainless steel coil and connected at its distal end to the connection of the distal end of the stainless steel coil and the detachable coil both said threadlike extension and said stainless steel coil needing to be electrolytically disintegrated at least at one point in order to detach the detachable coil from the main body.

3. The apparatus of claim 1 wherein said distal portion is exposed stainless steel comprising a stainless steel coil connected at its proximal end to said core wire and connected at its distal end to said detachable coil, and wherein said stainless steel coil defines an interior space, said interior space being free and unreinforced.

4. The apparatus of claim 1, wherein the detachable coil is a long and pliable segment.

5. The apparatus of claim 4 wherein said detachable coil has a length sufficient to substantially fill the cavity when disposed therein.

6. The apparatus of claim 1 wherein the detachable coil is comprised of a metal not susceptible to electrolytic disintegration.

7. The apparatus of claim 1 wherein the detachable coil is prebiased to form a helix or spiral when advanced from a microcatheter into the cavity.

8. The apparatus of claim 7 wherein the detachable coil is prebiased to have a conical envelope.

9. The apparatus of claim 7 wherein the detachable coil is prebiased to have a cylindrical envelope.

10. The apparatus of claim 7 wherein although prebiased the detachable coil is extremely soft and its overall shape is easily deformed such that, once advanced from a microcatheter into the cavity, it will loosely deform to the interior shape of the cavity.

11. The apparatus of claim 1 wherein the detachable coil is unbiased.

12. The apparatus of claim 1 wherein the main body of the core wire is covered with insulation to prevent the underlying portion of the apparatus from coming into contact with any fluid.