Consumable gummy delivery system

• US 5,928,664 A
• Filed: 02/11/1998
• Issued: 07/27/1999
• Est. Priority Date: 02/11/1998
• Status: Expired due to Fees

• Current Assignee: Fuisz Technologies Limited (Bausch Health Cos., Inc.)
• Original Assignee: Fuisz Technologies Limited (Bausch Health Cos., Inc.)
• Inventors: Yang, Robert K., Oh, T. Victor
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): FAULKNER, DIEDRA SARRAE
• Application Number:
  US09/022,244
• Time in Patent Office: 531 Days
• Field of Search: 424/441, 424/404, 424/440, 424/465, 514/948
• US Class Current: 424/440
• CPC Class Codes: A23G 2200/04 containing vitamins, antibiotics, other medicaments
• CPC Class Codes: A23G 2200/06 containing beet sugar or cane sugar if specifically mentioned or containing other carbohydrates, e.g. starches, gums, alcohol sugar, polysaccharides, dextrin or containing high or low amount of carbohydrate
• CPC Class Codes: A23G 2220/02 Foamed, gas-expanded or cellular products
• CPC Class Codes: A23G 3/346 Finished or semi-finished products in the form of powders, paste or liquids A23G3/343 takes precedence
• CPC Class Codes: A61K 9/0056 Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
• CPC Class Codes: A61K 9/2063 Proteins, e.g. gelatin

Abstract

The present invention provides consumable, gummy delivery systems and methods of making the same. The gummy delivery systems include an active ingredient admixed with a glycerylated gelatin matrix prepared by heating an aqueous solution of gelatin and glycerin to a temperature and for a time sufficient to remove some of the moisture content of the initial aqueous solution. The active ingredient can be delivered from a shearform matrix carrier.

Claims

1. A consumable, gummy delivery system which comprises:

an elastic, continuous glycerylated gelatin matrix prepared by heating an aqueous solution of gelatin admixed with glycerin to a temperature and for a time sufficient to remove about 100% by weight of initial moisture content to provide a gummy glycerylated gelatin matrix as an elastic, water soluble solid; and

one or more active ingredients in the form of a shearform matrix admixed with said glycerylated gelatin matrix, whereby said consumable gummy deliver system is formed which is readily soluble in aqueous media;

wherein said results glycerylated gelatin matrix contains about 0% moisture.

2. A consumable, gummy delivery system which comprises:

an elastic, continuous glycerylated gelatin matrix prepared by heating an aqueous solution of gelatin admixed with glycerin to a temperature and for a time sufficient to remove from about 10% to about 100% by weight of initial moisture content to provide a gummy glycerylated gelatin matrix as an elastic, water soluble solid; and

one or more active ingredients in the form of a shearform matrix admixed with said glycerylated gelatin matrix, whereby said consumable gummy delivery system is formed which is readily soluble in aqueous media;

wherein said glycerine is present in an amount of from about 10% by weight to about 50% by weight of said gummy delivery system.

3. A consumable, gummy delivery system which comprises:

an elastic, continuous glycerylated gelatin matrix prepared by heating an aqueous solution of gelatin admixed with glycerin to a temperature and for a time sufficient to remove about 100% by weight of initial moisture content to provide a gummy glycerylated gelatin matrix as an elastic, water soluble solid; and

one or more active ingredients in the form of a shearform matrix admixed with said glycerylated gelatin matrix, whereby said consumable gummy delivery system is formed which is readily soluble in aqueous media;

wherein said glycerylated gelatin matrix contains residual moisture in an amount of about 0% by weight of said matrix.

4. A consumable, gummy delivery system which comprises:

an elastic, continuous glycerylated gelatin matrix prepared by heating an aqueous solution of gelatin admixed with glycerin to a temperature and for a time sufficient to remove from about 10% to about 100% by weight of initial moisture content to provide a gummy glycerylated gelatin matrix as an elastic, water soluble solid; and

one or more active ingredients provided as a component of a shearform matrix carrier prepared by flash-flow processing a feedstock comprising said active ingredient and a carrier material, said processed active ingredient being further admixed with said glycerylated gelatin matrix, whereby said consumable gummy delivery system is formed which is readily soluble in aqueous media; and

wherein said active ingredient is selected from the group consisting of medicaments, flavors, sweeteners and mixtures thereof.

5. The delivery system of claim 4, wherein said carrier material is selected from the group consisting of saccharides, water soluble cellulosics and mixtures thereof.

6. The delivery system of claim 5, wherein said saccharide is corn syrup solids.

7. The delivery system of claim 4, wherein said feedstock further comprises one or more additives selected from the group consisting of fats, medium chain triglycerides, flavors, sweeteners, colorings, humectants, fillers, emulsifiers, thickeners and mixtures thereof.

8. A consumable, gummy delivery system which comprises:

an elastic, continuous glycerylated gelatin matrix prepared by heating an aqueous solution of gelatin admixed with glycerin to a temperature and for a time sufficient to remove from about 10% to about 100% by weight of initial moisture content to provide a gummy glycerylated gelatin matrix as an elastic, water soluble solid; and

one or more active ingredients in the form of a shearform matrix admixed with said glycerylated gelatin matrix, whereby said consumable gummy delivery system is formed which is readily soluble in aqueous media;

wherein said shearform matrix is prepared by flash-flow processing.

9. A consumable, gummy delivery system which comprises:

an elastic, continuous glycerylated gelatin matrix prepared by heating an aqueous solution of gelatin admixed with glycerin to a temperature and for a time sufficient to remove from about 10% to about 100% by weight of initial moisture content to provide a gummy glycerylated gelatin matrix as an elastic, water soluble solid; and

one or more active ingredients in the form of a shearform matrix admixed with said glycerylated gelatin matrix, whereby said consumable gummy delivery system is formed which is readily soluble in aqueous media;

wherein said gelatin is further provided as a component of a shearform matrix.

10. The delivery system of claim 9, wherein said shearform matrix for at least one of said active ingredient(s) and said gelatin further comprises a carrier material.

11. The delivery system of claim 10, wherein said carrier material is selected from the group comprising of saccharides, water soluble cellulosics and mixtures thereof.

12. A consumable gummy delivery system for an active which comprises:

an elastic, continuous glycerylated gelatin matrix including an active-bearing shearform matrix carrier prepared by flash-flow processing, said shearform matrix carrier comprising a carrier material and an active ingredient.

34. The delivery system of claim 12, said delivery system having about 0% moisture.

13. A method of preparing a consumable gummy delivery system comprising:

(i) providing an elastic, continuous glycerylated gelatin matrix;

(ii) mixing said glycerylated gelatin matrix with an active ingredient to form a homogeneous mixture which is elastic, continuous and readily soluble in aqueous media;

(iii) forming the resulting mixture into suitable chewable shapes.

14. The method of claim 13, wherein said glycerylated gelatin matrix is prepared by heating an aqueous solution of gelatin and glycerin to a temperature and for a time sufficient to remove from about 10% to about 100% of initial moisture of said gummy delivery system.

15. The method of claim 13, wherein said glycerylated gelatin matrix is present in an amount of from about 2% by weight to about 70% by weight of the gummy delivery system.

16. The method of claim 13, wherein said gelatin is present in an amount of from about 2% by weight to about 50% by weight of said gummy delivery system.

17. The method of claim 13, wherein said gelatin is present in an amount of from about 5% by weight to about 30% by weight of said gummy delivery system.

18. The method of claim 13, wherein said glycerine is present in an amount from about 4% by weight to about 60% by weight of said gummy delivery system.

19. The method of claim 13, wherein said glycerine is present in an amount from about 10% by weight to about 50% by weight of said gummy delivery system.

20. The method of claim 13, wherein said active ingredient is selected from the group consisting of medicaments, flavors, sweeteners and mixtures thereof.

21. The method of claim 20, wherein said medicament is selected from the group consisting of antitussives, antihistamines, decongestants, alkaloids, mineral supplements, laxatives, vitamins, antacids, ion exchange resins, anticholesterolemics, antilipid agents, antiarrhythmics, antipyretics, analgesics, appetite suppressants, expectorants, anti-inflammatory substances, coronary dilators, cerebral dilators, penpheral vasocilators, antiinfectives, psychotropics, antimanics, stimulants, gastrointestinal agents, sedatives, antidiarrheal preparations, antianginal drugs, vasodialators, antihypertensive drugs, vasoconstrictors and migraine treatments, antibiotics, tranquilizers, antipsychotics, antitumor drugs, anticoagulants and antithrombotic drugs, hypnotics antiemetics, antinauseants, anticonvulsants, neuromuscular drugs, hyper- and hypoglycemic agents, thyroid and antithyroid preparations, diuretics, antispasmodics, uterine relaxants, mineral and nutritional additives, antiobesity drugs, anabolic drugs, erythropoietic drugs, antiasthmatics, cough suppressants, mucolytics, antiuricemic drugs, and mixtures thereof.

22. The method of claim 20, wherein said flavor is selected from the group consisting of natural flavors, artificial flavors and mixtures thereof.

23. The method of claim 22, wherein said natural flavors is selected from the group consisting of peppermint oil, spearmint oil, eucalyptus oil, cinnamon oil, menthol, oil of wintergreen (methylsalicylate), citrus oils, fruit essences and mixtures thereof.

24. The method of claim 22, wherein said artificial flavor is selected from the group of artificial sweeteners, synthetic flavor oils, aldehydes and esters.

25. The method claim 24, wherein said artificial sweetener is selected from the group consisted of saccharin, saccharin salts, cyclamic acid, cyclamic acid salts, aspartame, sucralose, acesulfame, and combinations thereof.

26. The method of claim 13, wherein comprising one or more additives admixed with said glycerylated gelatin matrix.

27. The method of claim 26, wherein said additive is selected from the group consisting of fats, medium chain triglycerides, sweeteners, flavors, colorings, humectants, fillers, emulsifiers, thickeners and mixtures thereof.

28. The method of claim 13, wherein said active ingredient is provided as a shearform matrix carrier prepared by flash flow processing a feedstock comprising an active ingredient and a carrier material.

29. The method of claim 28, wherein said carrier material is selected from the group consisting of saccharides, water soluble cellulosics and mixtures thereof.

30. The method of claim 29, wherein said saccharide is corn syrup solids.

31. The method of claim 27, wherein said feedstock further comprises one or more additives selected from the group consisting of fats, medium chain triglycerides, flavors, sweeteners, colorings, humectants, fillers, emulsifiers, thickeners and mixtures thereof.

32. The method of claim 13, further comprising a shearform matrix prepared by flash-flow processing.

33. The method of claim 13, wherein said gelatin is provided as a component of said shearform matrix.

35. The method of claim 14, wherein about 100% of initial moisture of said gummy delivery system is removed.