Method for treating sleep disorders

• US 5,929,065 A
• Filed: 03/01/1996
• Issued: 07/27/1999
• Est. Priority Date: 07/13/1995
• Status: Expired due to Term

• Current Assignee: Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften e.V. (Max-Planck-Gesellschaft zur Frderung der Wissenschaften e)
• Original Assignee: Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften e.V. (Max-Planck-Gesellschaft zur Frderung der Wissenschaften e)
• Inventors: Lancel, Marike
• Primary Examiner(s): Wortman, Donna C.
• Assistant Examiner(s): Brumback, Brenda G.
• Application Number:
  US08/609,461
• Time in Patent Office: 1,243 Days
• Field of Search: 514/188
• US Class Current: 514/188
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/165 having aromatic rings, e.g. colchicine, atenolol, progabide
• CPC Class Codes: A61K 31/42 Oxazoles
• CPC Class Codes: A61K 31/4355 the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
• CPC Class Codes: A61K 31/4409 only substituted in position 4, e.g. isoniazid, iproniazid
• CPC Class Codes: A61K 31/4535 containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
• CPC Class Codes: A61P 25/20 Hypnotics; Sedatives
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The invention relates to a method of treating sleep disorders in a patient in need thereof comprising the administration of a hypnotically effective amount of a non-allosteric GABA_A agonist.

Claims

1. A method for treating a sleep disorder in a patient in need thereof comprising administering to said patient a hypnotically effective amount of 4,5,6,7-tetrahydroisoxazolo(5.4-C)pyridin-3-ol (THIP).

2. The method according to claim 1, wherein said patient is elderly.

3. The method according to claim 1, wherein said sleep disorder is difficulty in falling asleep.

4. The method according to claim 1, wherein said sleep disorder is frequent nocturnal arousal.

5. The method according to claim 1, wherein the amount of THIP administered is 5 to 50 mg per day.

6. A method for treating a sleep disorder in a patient in need thereof comprising administering to said patient a hypnotically effective amount of tiagabine.

7. The method according to claim 6, wherein said patient is elderly.

8. The method according to claim 6, wherein said sleep disorder is nocturnal arousal difficulty in falling asleep.

9. The method according to claim 6, wherein said sleep disorder is frequent nocturnal arousal.

10. The method according to claim 6, wherein the amount of tiagabine administered is 5 to 50 mg per day.