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Methods for electronic synthesis of polymers

  • US 5,929,208 A
  • Filed: 10/04/1996
  • Issued: 07/27/1999
  • Est. Priority Date: 11/01/1993
  • Status: Expired due to Term
First Claim
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1. An electronically controlled method for combinatorial synthesis of a biopolymer, comprising the steps of:

  • providing a plurality of reaction locations on a substrate, each reaction location being individually electronically addressable;

    providing an attachment layer upon at least some reaction locations;

    placing said reaction locations in contact with a solution containing a charged monomer-A;

    selectively biasing those locations at which monomer A is to react at an opposite charge to monomer-A, and biasing those locations at which monomer A is not to react at the same charge as monomer-A;

    concentrating and reacting monomer A on the specific A locations;

    removing unreacted monomer A;

    providing said reaction locations in contact with charged monomer B;

    selectively biasing those locations for which monomer B is to react at the opposite charge of monomer-B, and biasing those locations at which monomer B is not to react at the same charge as monomer-B;

    concentrating and reacting monomer B on the specific B locations;

    removing unreacted monomer B, andrepeating the process with monomers until all biopolymer sequences are complete.

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