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Carbohydrate-directed cross-linking reagents

  • US 5,929,211 A
  • Filed: 09/04/1997
  • Issued: 07/27/1999
  • Est. Priority Date: 08/05/1992
  • Status: Expired due to Term
First Claim
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1. A conjugate molecule having a glycoprotein covalently attached to a thiol-containing compound via a compound of formula I ##STR3## wherein the conjugate has a hydrazide moiety and a maleimide moiety, wherein the hydrazide and the maleimide moieties are separated by a spacer X,wherein X is an aliphatic hydrocarbon spacer of 6 to about 25 carbon atoms or consists of an aliphatic hydrocarbon chain and an alicyclic or aromatic moiety having a total number of 6 to about 25 carbon atoms,wherein X is covalently attached to the hydrazide moiety and X is covalently attached to the heteronitrogen of the maleimide moiety,wherein the glycoprotein is covalently attached to the hydrazide via a hydrazone linkage;

  • andwherein the thiol-containing compound is covalently attached to a heterocyclic carbon atom of the maleimide via a thioether linkage.

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