Method of fixing a physiologic mitral valve bioprosthesis
First Claim
1. A method for fixing a mitral valve in its natural geometry comprising the steps of:
- (a) collecting a whole animal heart having myocardium, endocardium, a mitral valve having an annulus, chordae tendineae, papillary heads, left ventricle and left atrium shortly after the death of an animal;
(b) exposing, but not removing from the whole animal heart, the mitral valve, chordae tendineae and papillary heads of the animal heart such that major portions of the left ventricle and left atrium remain along with the exposed mitral valve, chordae tendineae, and papillary heads;
(c) fixing the entire result of step (b) to preserve the natural geometry of the mitral valve in situ with the major portions of the left ventricle and left atrium;
(d) excising tissue from the result of step (c), the excised tissue including the mitral valve, the annulus, and a portion of the endocardium containing the papillary heads, so that for each set of chordae tendineae and papillary head exposed in step (b), the entire chordae tendineae and substantially the entire corresponding papillary head are included in the excised tissue; and
(e) retaining the excised tissue while disposing the remainder of the fixed result of step (c).
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Abstract
A whole heart is collected shortly after the death of the animal. The left ventricle and left atrium of the animal heart is sectioned and exposed thereby exposing the mitral valve, the chordae tendineae and the papillary heads. The mitral valve is fixed in situ by fixing portions of the left ventricle and left atrium containing the mitral valve. The mitral valve is excised from the animal heart remnant to include a portion of the endocardium containing the papillary heads and the annulus. In the preferred embodiment of the invention, the excised mitral valve is further fixed to complete fixation of the papillary heads. Then, the excess myocardial tissue is trimmed away and the mitral valve is stored in fixing solution to await further processing.
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Citations
19 Claims
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1. A method for fixing a mitral valve in its natural geometry comprising the steps of:
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(a) collecting a whole animal heart having myocardium, endocardium, a mitral valve having an annulus, chordae tendineae, papillary heads, left ventricle and left atrium shortly after the death of an animal; (b) exposing, but not removing from the whole animal heart, the mitral valve, chordae tendineae and papillary heads of the animal heart such that major portions of the left ventricle and left atrium remain along with the exposed mitral valve, chordae tendineae, and papillary heads; (c) fixing the entire result of step (b) to preserve the natural geometry of the mitral valve in situ with the major portions of the left ventricle and left atrium; (d) excising tissue from the result of step (c), the excised tissue including the mitral valve, the annulus, and a portion of the endocardium containing the papillary heads, so that for each set of chordae tendineae and papillary head exposed in step (b), the entire chordae tendineae and substantially the entire corresponding papillary head are included in the excised tissue; and (e) retaining the excised tissue while disposing the remainder of the fixed result of step (c). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method for fixing a mitral valve from a heart comprising the steps of:
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(a) collecting a whole animal heart having myocardium, endocardium, a mitral valve having an annulus, chordae tendineae, papillary heads, left ventricle and left atrium shortly after the death of an animal; (b) exposing, but not removnig from the whole animal heart, the mitral valve, chordae tendineae and papillary heads of the animal heart such that major portions of the left ventricle and left atrium remain along with the exposed mitral valve, chordae tendineae, papillary heads; (c) fixing the entire result of step (b) to preserve the natural geometry of the mitral valve in situ with the major portions of the left ventricle and left atrium; (d) excising the tissue from the result of step (c), the excised tissue including the mitral valve, the annulus, and a portion of the endocardium containing the papillary heads, so that for each set of chordae tendineae and papillary head exposed in step (b, the entire chordae tendineae and substantially the entire corresponding papillary head are included in the excised tissue; (e) retaining the excised tissue while disposing the remainder of the fixed result of step (c); (f) completing fixation of the papillary heads; and
,(g) trimming away excess myocardial tissue from the fixed result of step (d).
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10. A mitral valve fixed according to a method for fixing a mitral valve from a heart, the method comprising the steps of:
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collecting a whole animal heart having myocardium, endocardium, a mitral valve, chordae tendineae, papillary heads, left ventricle and left atrium shortly after the death of an animal, the mitral valve having an annulus; sectioning the left ventricle and left atrium of the animal heart thereby exposing the mitral valve, chordae tendineae and papillary heads of the animal heart, the resulting mitral valve, chordae tendineae, papillary heads and portions of the left ventricle and left atrium forming a heart remnant; fixing the animal heart remnant including the mitral valve; excising the mitral valve from the animal heart remnant to include the annulus, a portion of the endocardium containing the papillary heads so that for each set of chordae tendineae and papillary head, the entire chordae tendineae and substantially the entire corresponding papillary head is removed. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
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19. A mitral valve fixed according to the method for fixing a mitral valve from a heart comprising the steps of:
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collecting a whole animal heart having myocardium, endocardium, a mitral valve, chordae tendineae, papillary heads, left ventricle and left atrium shortly after the death of an animal, the mitral valve having an annulus; sectioning the left ventricle and left atrium of the animal heart thereby exposing the mitral valve, chordae tendineae and papillary heads of the animal heart, the resulting mitral valve, chordae tendineae, papillary heads and portions of the left ventricle and left atrium forming a heart remnant; fixing the animal heart remnant including the mitral valve; excising the mitral valve from the animal heart remnant to include the annulus, a portion of the endocardium containing the papillary heads so that for each set of chordae tendineae and papillary head, the entire chordae tendineae and substantially the entire corresponding papillary head is removed; fixing the animal heart remnant to complete fixation of the papillary heads; trimming away excess myocardial tissue from the heart remnant.
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Specification