Method for modifying the surface of an object

• US 5,932,299 A
• Filed: 04/22/1997
• Issued: 08/03/1999
• Est. Priority Date: 04/23/1996
• Status: Expired due to Fees

• Current Assignee: KT Holdings, LLC
• Original Assignee: Mohammad W. Katoot
• Inventors: Katoot, Mohammad W.
• Primary Examiner(s): PIANALTO, BERNARD D
• Application Number:
  US08/837,791
• Time in Patent Office: 833 Days
• Field of Search: 427/508, 427/512, 427/521, 427/557, 427/559, 427/595, 427/385.5
• US Class Current: 427/508
• CPC Class Codes: A61L 2400/18 Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 33/062 Mixtures of macromolecular compounds
• CPC Class Codes: B05D 7/00 Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials coating of foodstuffs A23P20/17, A23P20/15, A23P20/18
• CPC Class Codes: D06M 10/001 Treatment with visible light, infrared or ultraviolet, X-rays
• CPC Class Codes: D06M 10/003 Treatment with radio-waves or microwaves
• CPC Class Codes: D06M 10/025 Corona discharge or low temperature plasma
• CPC Class Codes: D06M 10/04 Physical treatment combined with treatment with chemical compounds or elements graft polymerisation using wave energy or particle radiation D06M14/18 ; treatment with radioactive elements D06M10/008
• CPC Class Codes: D06M 10/10 Macromolecular compounds
• CPC Class Codes: D06M 14/18 using wave energy or particle radiation
• CPC Class Codes: D06M 14/20 on to materials of natural origin
• CPC Class Codes: D06M 14/26 on to materials of synthetic origin
• CPC Class Codes: D06M 16/003 with enzymes or microorganisms
• CPC Class Codes: D06M 2200/00 Functionality of the treatment composition and/or properties imparted to the textile material
• CPC Class Codes: D06M 2200/12 Hydrophobic properties
• CPC Class Codes: D06M 2200/40 Reduced friction resistance, lubricant properties; Sizing compositions

Abstract

The present invention relates to several novel compositions and methods employing infrared radiation, microwave radiation or high voltage polymerization for modifying the surfaces of materials to impart desired characteristics thereto. More particularly, the present invention relates to a method for modifying the surfaces of objects to increase the lubricity, hydrophilicity, hydrophobicity, or biofunctionality of the surface of the object.

Claims

1. A method of modifying a surface of an object, comprising:

coating the object with a micrograft initiator and a hydrophilic polymer, a hydrophobic polymer, or a biofunctional compound, or a combination of these; and

,

exposing the coated object to infrared radiation, microwave radiation or high voltage polymerization, thereby producing a graft to the surface.

2. The method of claim 1, wherein the object is selected from the group consisting of metals, woods, polymers, ceramics, plastics, fibers and composites thereof.

3. The method of claim 1, wherein the object is a medical device, surgical instrument or an implant.

4. The method of claim 1, wherein the object is a web.

5. The method of claim 1, wherein the surface is made from substances comprising fluorocarbon polymers, polyolefins, polyolefin/hydrocarbon polymers, polyvinyl chloride, polypropylene, polystyrene, silicone, polyacrylates, methacrylates, styrene-butadiene copolymers, ethylene propylene copolymers, styrene-ethylene/butadiene/styrene block copolymers, polycarbonates, fluorocarbon polymers, polyperfluoroethylenepropylene, polysiloxanes, polyurethanes, polyurethane polyester, polyether block copolymers, polyvinyl chloride, polyesters, polyethylene terephthalate, vinyl, or polycarbonate/polydimethylsiloxane copolymer.

6. The method of claim 1, wherein the biofunctional compound comprises a protein, receptor, enzyme, enzyme inhibitor, immunological molecule, hormone, neurotransmitter, peptide, lipid, phospholipid, nucleic acid, sugar, carbohydrate, glycoprotein, lectin, bacterium, virus, replication inhibitor, protease, antibiotic, antifungal, bacteriostatic compound, toxin, microbial, anti-microbial, growth factor, angiogenic factor, nutrient, phosphatidylcholine, anti-coagulent, or vitamin.

7. The method of claim 1, wherein the hydrophilic polymer comprises hydroxyethyl methacrylate, N-vinyl pyrrolidinone, carboxymethyl cellulose, acrylamide, polyethylene glycol, hydroxypropyl acrylamide, sulfopropyl acrylate, styrene sulfonic acid, potassium styrene sulfonic propyl acrylate, methacrylamide, acrylate, acrylic acid, methacrylic acid, hexa(hydroxypropylcarbamlymethyl)melamine, ethylhydroxyethyl cellulose, or protein.

8. The method of claim 1, wherein the hydrophobic polymer comprises polyolefin, isobutene, methacrylate, hydroxyethyl methacrylate, halogenated polymer, fluorinated polymer, or styrene polymers.

9. The method of claim 1, wherein the micrograft initiator comprises:

a first solution of polyvinyl alcohol, ethylene glycol, and polyaniline dissolved in N-methyl pyrrolidinone;

a second solution of copper perchlorate; and

a third solution comprising a mixture of the second solution, the first solution, acid and peroxide.

10. The method of claim 9, wherein the second solution is copper perchlorate in methanol.

11. The method of claim 9, wherein the second solution is copper perchlorate in tetrahydrofuran.

12. The method of claim 9, wherein the second solution is copper perchlorate in isopropyl alcohol.

13. The method of claim 1, wherein the micrograft initiator comprises:

a first solution of polyvinyl alcohol, acid, and polyaniline dissolved in N-methyl pyrrolidinone;

a second solution of copper perchlorate in tetrahydrofuran, and ethylene glycol; and

a third solution comprising a mixture of the second solution, the first solution, phenol and peroxide.

14. The method of claim 1, wherein the micrograft initiator comprises:

a first solution of polyvinyl alcohol, and polyaniline dissolved in N-methyl pyrrolidinone;

a second solution of copper perchlorate in isopropyl alcohol; and

a third solution comprising a mixture of the second solution, the first solution, acid and peroxide.

15. The method of claim 1, wherein the micrograft initiator comprises:

a first solution of polyvinyl alcohol, polyaniline dissolved in N-methyl pyrrolidinone, and acid;

a second solution of copper perchlorate in isopropyl alcohol, and ethylene glycol; and

a third solution comprising a mixture of the second solution, the first solution, and peroxide.

16. The method of claim 1, wherein the micrograft initiator comprises:

a first solution of polyvinyl alcohol, polyaniline dissolved in N-methyl pyrrolidinone, and acid;

a second solution of copper perchlorate in tetrahydrofuran, and ethylene glycol; and

a third solution comprising a mixture of the second solution, the first solution, and peroxide.

17. The method of claim 1, wherein the micrograft initiator comprises:

a first solution of aqueous carboxymethylcellulose, and polyaniline dissolved in N-methyl pyrrolidinone;

a second solution of p-toluenesulfonic acid in acetonitrile, and water; and

a third solution comprising a mixture of the second solution, the first solution, and peroxide.

18. A method of modifying a surface of an object, comprising:

coating the object with (a) a micrograft initiator and (b) a hydrophilic polymer, a hydrophobic polymer, a biofunctional compound, or a combination of these; and

,

exposing the coated object to infrared radiation, microwave radiation or high voltage polymerization, thereby producing a graft to the surface, wherein the object is a medical device, surgical instrument or an implant.

19. The method of claim 18, wherein the medical device comprises a catheter, intravenous catheter, central venous catheter, stent, wire, guidewire, graft, balloon, suture, screw, staple, pin, plate, drainage device, shunt, tube, gastrointestinal tubes, enteral feeding tubes, vascular tube, vascular shunt, tube for placement in the respiratory system, endotracheal and tracheostomy tubes and cuffs, tube to drain the middle ear, wound drainage tube, fluid drainage tube, tube for placement in the urinary system, tube for placement in the reproductive system, tube for placement in the cardiovascular system, tube which act as shunts, cuff, pump, minipump, electrode, prosthetic device, artificial joint, artificial lens, laser angioplasty device, balloon angioplasty device, ventricular assist, blood dialysis components, blood oxygenators, blood bags, test tubes, blood collection tubes, vacutainers, syringes, needles, pipettes, pipette tips, blood tubing or a contact lens.

20. The method of claim 18, wherein the implant comprises an artificial knee, ankle, hip, shoulder, thyroplastic device, laryngoplastic device, artificial larynx, pump, tube, shunt, intraocular implant, lens implant, contact lens, electrode, corneal inlay, kerato-prosthesis, vascular stent, epikeratophalia device, glaucoma shunt, retinal staple, scleral buckle, dental prosthesis, dental implants, vascular graft, soft tissue prosthesis, hard tissue prosthesis, pumps, electrical devices including stimulators and recorders, auditory prosthesis, pacemaker, mammary implant, penile implant, cranio/facial tendon, artificial joint, tendon, ligament, menisci, disks, artificial bone, artificial organs including artificial pancreas, artificial heart, artificial limb or heart valve.

21. The method of claim 18, wherein the surgical instrument comprises a probe, retractor, tissue separator, vessel separator, irrigation tool, aspiration tool, phacoemulsification tool, sponge, hemostat, clamp, blade, scalpel blades, glove, lens glide, positioning tool, catheter, forceps, insertion tool, staple or suture.

22. The method of claim 18 wherein the micrograft initiator comprises:

a first solution of polyvinyl alcohol, ethylene glycol, and polyaniline dissolved in N-methyl pyrrolidinone;

a second solution of copper perchlorate; and

a third solution comprising a mixture of the second solution, the first solution, acid and peroxide.

23. The method of claim 18, wherein the hydrophilic polymer comprises hydroxyethyl methacrylate, N-vinyl pyrrolidinone, carboxymethyl cellulose, acrylamide, polyethylene glycol, hydroxypropyl acrylamide, sulfopropyl acrylate, styrene sulfonic acid, potassium styrene sulfonic propyl acrylate, methacrylamide, acrylate, acrylic acid, methacrylic acid, hexa(hydroxypropylcarbamlymethyl)melamine, ethylhydroxyethyl cellulose, or protein.

24. A method of modifying a surface of an object, comprising:

coating the object with (a) a rhicrograft initiator and (b) a hydrophilic polymer, a hydrophobic polymer, a biofunctional compound, or a combination thereof;

wherein the micrograft initiator comprises (a) a first solution containing polyaniline dissolved in N-methyl pyrrolidinone, (b) a second solution containing copper, perchiorate or p-toluenesulfonic acid, and (c) a peroxide; and

exposing the coated object to infrared radiation, microwave radiation or high voltage polymerization, thereby producing a graft to the surface.

25. The method of claim 24, wherein the object is selected from the group consisting of metals, woods, polymers, ceramics, plastics, fibers and composites thereof.

26. The method of claim 24, wherein the object is a medical device, surgical instrument or an implant.