Quinazoline derivatives
First Claim
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1. A quinazoline derivative of the formula I ##STR4## wherein n is 1, 2 or 3 and each R2 is independently halogeno;
- and R1 is di- (1-4C)alkyl!amino-(2-4C)alkoxy. pyrrolidin-1-yl-(2-4C)alkoxy, piperidino-(2-4C)alkoxy, morpholino-(2-4C)alkoxy, piperazin-1-yl-(2-4C)alkoxy or 4-(1-4C)alkylpiperazin-1-yl-(2-4C)alkoxy;
or a pharmaceutically-acceptable salt thereof.
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Abstract
The invention concerns quinazoline derivatives of formula wherein n is 1, 2 or 3 and each R2 is independently halogeno; and R1 is di- (1-4C)alkyl!amino-(2-4C)alkoxy, pryolidin-1-yl-(2-4C)alkoxy,piperidino-(2-4C)alkoxy, morpholino-(2-4C)alkoxy, piperazin-1-yl-(2-4C)alkoxy or 4-(1-4C)alkylpiperazin-1-yl-(2-4C)alkoxy; or pharmaceutically-acceptable salts thereof; processes for their preparation, pharmaceutical compositions containing them, and the use of the receptor tyrosine kinase inhibitory properties of the compounds in the treatment of proliferative disease such as cancer.
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8 Claims
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1. A quinazoline derivative of the formula I ##STR4## wherein n is 1, 2 or 3 and each R2 is independently halogeno;
and R1 is di- (1-4C)alkyl!amino-(2-4C)alkoxy. pyrrolidin-1-yl-(2-4C)alkoxy, piperidino-(2-4C)alkoxy, morpholino-(2-4C)alkoxy, piperazin-1-yl-(2-4C)alkoxy or 4-(1-4C)alkylpiperazin-1-yl-(2-4C)alkoxy; or a pharmaceutically-acceptable salt thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
Specification