Chemo-mechanical expansion delivery system
First Claim
1. A method for controlled delivery of a biologically active composition to a biological environment comprising:
- selecting a drug delivery apparatus comprising;
first and second compartments separated by a moveable partition, the first compartment including a screen or membrane forming at least a portion of a side of the first compartment, the first compartment containing a polymer gel network capable of a volume change in response to an environmental condition which varies in the biological environment,the second compartment containing an effective amount of the biologically active compound and including an orifice communicating with the biological environment,disposing the selected apparatus into a varying environment whereupon a change in environment causes a volume change in the polymer network thereby causing the biologically active compound to be delivered to the environment.
6 Assignments
0 Petitions
Accused Products
Abstract
System for delivery of a biologically active substance into an environment. First and second chambers are separated by a moveable partition. The first chamber includes a polymer gel network which undergoes a volume change in response to an environmental condition such as pH. The first compartment includes a screen or membrane for confining the polymer gel network while allowing communication with fluid in an environment. The second compartment contains a biologically active compound or drug which is delivered to the environment through an orifice in the second compartment. Upon the occurrence of the triggering environmental condition, the polymer gel network undergoes a volume change which moves the moveable partition expelling the drug through the orifice. Drug delivery is initiated and continues only when the appropriate environmental condition or trigger is met.
81 Citations
5 Claims
-
1. A method for controlled delivery of a biologically active composition to a biological environment comprising:
-
selecting a drug delivery apparatus comprising; first and second compartments separated by a moveable partition, the first compartment including a screen or membrane forming at least a portion of a side of the first compartment, the first compartment containing a polymer gel network capable of a volume change in response to an environmental condition which varies in the biological environment, the second compartment containing an effective amount of the biologically active compound and including an orifice communicating with the biological environment, disposing the selected apparatus into a varying environment whereupon a change in environment causes a volume change in the polymer network thereby causing the biologically active compound to be delivered to the environment. - View Dependent Claims (2, 3, 4, 5)
-
Specification