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Modified amino acids for drug delivery

  • US 5,935,601 A
  • Filed: 10/22/1996
  • Issued: 08/10/1999
  • Est. Priority Date: 04/22/1994
  • Status: Expired due to Term
First Claim
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1. A composition comprising:

  • (A) at least one biologically active agent, and(B) (a) at least one acylated amino acid;

    (b) at least one peptide comprising at least one acylated amino acid;

    or (c) a combination of (a) and (b);

    wherein said acylated amino acid is acylated by(i) a C3 -C10 cycloalkyl acylating agent, substituted with C1 -C7 alkyl, C2 -C7 alkenyl, C1 -C7 alkoxy, hydroxy, phenyl, phenoxy, or --CO2 R, wherein R is hydrogen, C1 -C4 alkyl or C2 -C4 alkenyl;

    (ii) an unsubstituted C3 -C10 cycloalkyl;

    or(iii) a C1 -C6 alkyl acylating agent substituted with C3 -C10 cycloalkyl.

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