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Formulation for I.V. administration of the boron delivery drug, boronophenylalanine (BPA)

  • US 5,935,944 A
  • Filed: 02/20/1996
  • Issued: 08/10/1999
  • Est. Priority Date: 09/10/1993
  • Status: Expired due to Fees
First Claim
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1. A process for formulating a boronophenylalanine solution for use in a boron neutron capture therapy cancer treatment, the process comprising:

  • a. mixing boronophenylalanine (BPA) with a saccharide in water, thereby forming a mixed solution;

    b. increasing the pH of the mixed solution to a pH of about 10; and

    then,c. readjusting the pH of the solution to about 7.4, thereby forming a high concentration BPA solution at a physiologically relevant pH.

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