Formulation for I.V. administration of the boron delivery drug, boronophenylalanine (BPA)
First Claim
1. A process for formulating a boronophenylalanine solution for use in a boron neutron capture therapy cancer treatment, the process comprising:
- a. mixing boronophenylalanine (BPA) with a saccharide in water, thereby forming a mixed solution;
b. increasing the pH of the mixed solution to a pH of about 10; and
then,c. readjusting the pH of the solution to about 7.4, thereby forming a high concentration BPA solution at a physiologically relevant pH.
1 Assignment
0 Petitions
Accused Products
Abstract
A process and product formulated by complexing boronophenylalanine (BPA) and related compounds with a saccharide in an aqueous solution are disclosed. Formation of the complex is facilitated by raising the pH of the solution to a higher pH of about 10 or by lowering the pH of the solution to a lower pH of about 2 and then readjusting the pH to a body physiological pH of about 7.4. This BPA saccharide complex can then be delivered by i.v. or other injection or administered orally as a key component of the BNCT cancer treatment process The pH manipulation causes a much higher solubility of BPA or related compounds and thus a higher boron concentration in the tumor, thereby improving the therapy.
-
Citations
19 Claims
-
1. A process for formulating a boronophenylalanine solution for use in a boron neutron capture therapy cancer treatment, the process comprising:
-
a. mixing boronophenylalanine (BPA) with a saccharide in water, thereby forming a mixed solution; b. increasing the pH of the mixed solution to a pH of about 10; and
then,c. readjusting the pH of the solution to about 7.4, thereby forming a high concentration BPA solution at a physiologically relevant pH. - View Dependent Claims (2, 3)
-
-
4. A process for formulating a boronophenylalanine solution for use in a boron neutron capture therapy cancer treatment, the process comprising:
-
a. mixing boronophenylalanine (BPA) with a saccharide in water, thereby forming a mixed solution; b. decreasing the pH of the mixed solution to a pH of about 2; and
then,c. readjusting the pH of the solution to about 7.4, thereby forming a high concentration BPA solution at a physiologically relevant pH. - View Dependent Claims (5, 6)
-
-
7. A product for use in boron neutron capture therapy cancer treatment made by the method comprising:
-
a. mixing boronophenylalanine (BPA) with a saccharide in water, thereby forming a mixed solution; b. increasing the pH of the mixed solution to a pH of about 10; and
then,c. readjusting the pH of the solution to about 7.4, thereby forming a high concentration BPA solution of greater than 50 mg/ml at a physiologically relevant pH. - View Dependent Claims (8, 9, 10, 11)
-
-
12. A product for use in boron neutron capture therapy cancer treatment made by the method comprising:
-
a. mixing boronophenylalanine (BPA) with a saccharide in water, thereby forming a mixed solution; b. decreasing the pH of the mixed solution to a pH of about 2; and
then,c. readjusting the pH of the solution to about 7.4, thereby forming a high concentration BPA solution of greater than 50 mg/ml at a physiologically relevant pH. - View Dependent Claims (13, 14, 15, 16)
-
- 17. An aqueous solution for use in a boron neutron capture therapy cancer treatment comprising, in a concentration of greater than 50 mg/ml, a compound selected from the group consisting of boronphenylalanine (BPA), a structural modification of BPA, or an amino acid analog of BPA.
Specification