Method and device for heating by means of ultrasound

• US 5,938,600 A
• Filed: 12/09/1996
• Issued: 08/17/1999
• Est. Priority Date: 12/14/1995
• Status: Expired due to Term

• Current Assignee: US Philips Corporation (Koninklijke Philips N.V.)
• Original Assignee: US Philips Corporation (Koninklijke Philips N.V.)
• Inventors: Hofland, Lennart, Van Vaals, Johannes J.
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US08/767,596
• Time in Patent Office: 981 Days
• Field of Search: 128/653.2, 128/653.3, 128/653.5, 601/2-4, 324/306, 324/309, 600/411, 600/419, 600/410
• US Class Current: 600/411
• CPC Class Codes: A61B 2090/374 NMR or MRI
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00
• CPC Class Codes: G01R 33/4804 Spatially selective measurement of temperature or pH
• CPC Class Codes: G01R 33/563 of moving material, e.g. flow contrast angiography

Abstract

A method of heating a target region by ultrasound radiation includes determination of a position of the target region by a magnetic resonance method. The device for carrying out this method includes an ultrasound device and an MR device. By determining movement of the target region utilizing the MR device (100) and an appropriate magnetic resonance method, and by coupling the movement information to the ultrasound device (118) by an electric signal (122, 124), it is achieved that the ultrasound device can be controlled by the movement information. Various possibilities exist for controlling the ultrasound device. According to a first possibility, the focal region is adjusted to be situated within the target region in order to generate ultrasound. Another possibility is to determine from the movement information the instant at which the target region is situated within the focal region of the ultrasound and to generate ultrasound exclusively for a brief subsequent period during which the focal region is still within the target region. Another possibility is to refrain from generating ultrasound when the movement speed is too high. Finally, the movement information can also be used for making the focal region follow the target region during the generation of ultrasound.

Claims

1. A method of irradiating a moving target region within a body by ultrasound comprising:

performing by a magnetic resonance (MR) device the steps of

generating and receiving MR signals in the body,

processing the received MR signals,

determining automatically movement of the moving target region from the processed MR signals and,

generating automatically from the determined movement a control signal representing the determined movement of the moving target region,

performing by an ultrasound device the step of

irradiating automatically the body with ultrasound, the ultrasound device being responsive to the generated control signal so that a focal region of the ultrasound is in the moving target region, and

repeating the prior steps in order that the focal region of the ultrasound remains within the moving target region.

2. The method of claim 1 wherein the generated MR signals comprise first navigator signals.

3. The method of claim 2 wherein said step of determining movement comprises detecting an edge in the processed MR navigator signals.

4. The method of claim 2 wherein the first MR navigator signals are flow-sensitive, wherein the MR signals further comprise second flow-compensated MR navigator signals, and wherein said step of determining movement further comprises determining a speed of a moving region in the moving target region from the received first and second MR navigator signals.

5. The method of claim 2 wherein said step of generating the MR navigator signals comprises generating 2D RF pulses for exciting spins in the moving target region, and applying magnetic field gradients to the excited spins.

6. The method of claim 1 wherein the generated control signal represents a position of the moving target region.

7. The method of claim 6 wherein said step of irradiating comprises adjusting automatically the focal region of the ultrasound to a position represented by the generated control signal.

8. The method of claim 1 wherein said step of processing of the received MR signal comprises reconstructing an MR image.

9. The method of claim 8 wherein the MR signals are generated using a fast MR imaging pulse sequence.

10. The method of claim 8 wherein said step of determining movement comprises segmenting a reconstructed MR image.

11. The method of claim 1 wherein the control signal represents when the focal region of the ultrasound is in the moving target region.

12. The method of claim 11 wherein said step of generating a control signal comprises determining automatically a period during which the focal region of the ultrasound is situated within the moving target region, and wherein said step of irradiating comprises generating at least one ultrasound pulse during the period thus determined.

13. The method of claim 1 wherein the generated control signal represents a speed of the moving target region.

14. A device for irradiating a moving target region within a body by ultrasound comprising:

a magnetic resonance (MR) device comprising receiving means for generating and MR signals from the body,

means for processing the received MR signals and,

means for determining automatically movement of the moving target region from the processed MR signals and for generating automatically from the determined movement a control signal representing the determined movement of the moving target region, and

an ultrasound device for generating ultrasound to which the generated control signal is applied and which is responsive to the generated control signal so that a focal region of ultrasound radiation is in the moving target region.

15. The device of claim 14 wherein said means for determining generates a control signal which represents a position of the moving target region.

16. The device of claim 15 wherein said ultrasound device comprises a position control input, said ultrasound device being responsive to the position control input so that the focal region of generated ultrasound is at the position presented to the position control input, and the generated control signal being applied to the position control input.

17. The device of claim 16 wherein said MR device and said ultrasound device further comprise means for functioning repetitively whereby the focal region of ultrasound is repetitively controlled by repetitively generated control signals.

18. The device of claim 14 wherein said means for determining generates a control signal which represents a trigger reflecting when the focal region of the ultrasound is in the moving target region.

19. The device of claim 18 wherein said ultrasound device comprises a trigger input, said ultrasound device being responsive to the trigger input so that ultrasound radiation is generated upon presentation of a signal to the trigger input, and the generated control signal being applied to the trigger input.

20. The device of claim 14 wherein said means for determining comprises means for execution of an edge detection algorithm.

21. The device of claim 14 wherein said means for determining comprises means for execution of an image segmentation technique.