Peritoneal dialysis system with variable pressure drive

• US 5,938,634 A
• Filed: 08/23/1996
• Issued: 08/17/1999
• Est. Priority Date: 09/08/1995
• Status: Expired due to Term

• Current Assignee: Baxter International Inc.
• Original Assignee: Baxter International Inc.
• Inventors: Packard, Warren J.
• Primary Examiner(s): THANH, LOAN H
• Application Number:
  US08/702,878
• Time in Patent Office: 1,089 Days
• Field of Search: 604/29, 604/30, 604/67, 604/132, 604/141, 417/395, 128/DIG. 12, 128/DIG. 13
• US Class Current: 604/29
• CPC Class Codes: A61M 1/152 Details related to the interface between cassette and machine
• CPC Class Codes: A61M 1/1524 the interface providing means for actuating on functional elements of the cassette, e.g. plungers
• CPC Class Codes: A61M 1/154 with sensing means or components thereof
• CPC Class Codes: A61M 1/155 with treatment-fluid pumping means or components thereof
• CPC Class Codes: A61M 1/1561 at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
• CPC Class Codes: A61M 1/1565 Details of valves
• CPC Class Codes: A61M 1/159 specially adapted for peritoneal dialysis
• CPC Class Codes: A61M 1/166 Heating for sterilisation A61M1/1686
• CPC Class Codes: A61M 1/28 Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
• CPC Class Codes: A61M 1/281 Instillation other than by gravity
• CPC Class Codes: A61M 2205/123 with incorporated reservoirs
• CPC Class Codes: A61M 5/1483 using flexible bags externally pressurised by fluid pressure

Abstract

A variable pressure drive peritoneal dialysis system has a pneumatic pressure system for purging and controlling a flow of dialysate through a disposable dialysate cassette of a disposable dialysate delivery set. The pneumatic pressure system has a variable-opening flow proportional valve for supplying air at selected profiled pressure or vacuum to a pneumatic interface. The disposable dialysate cassette has a diaphragm pump actuable by the profiled air pressure or vacuum to move dialysate to and from a patient via the disposable dialysate delivery set at a desired profiled dialysate pressure.

Claims

1. A system for performing peritoneal dialysis on a patient comprising:

a) a liquid pump operated by fluid pressure to cause liquid to flow to and from a peritoneal cavity of a patent;

b) a fluid conduit to and from the liquid pump for providing fluid to operate the liquid pump;

c) a vacuum source for communicating negative pressure to the conduit and to the liquid pump to draw liquid into the liquid pump;

d) a positive pressure source for communicating positive pressure to the conduit and to the liquid pump to expel liquid from the liquid pump; and

e) a fluid distribution system including a flow proportional valve to control flow rate and pressure of the fluid through the fluid conduit from the respective pressure and vacuum sources to operate the liquid pump to cause liquid to be pumped into and from the peritoneal cavity.

2. A system for performing peritoneal dialysis on a patient according to claim 1 wherein the fluid distribution system comprises a selector valve for selectively connecting the vacuum source or the positive pressure source to the liquid pump.

3. A system for performing peritoneal dialysis on a patient according to claim 2 wherein the liquid pump comprises a diaphragm pump having a diaphragm and a fluid chamber, and the fluid distribution system further comprises a second flow proportional control valve and a second selector valve, each fluid chamber communicating with one of the flow proportional valves and one of the selector valves.

4. A system for performing peritoneal dialysis on a patient according to claim 1 wherein the fluid distribution system further comprises a second flow proportional control valve and a pump chamber.

5. A system for performing peritoneal dialysis on a patient according to claim 1 further comprising a liquid occluder for stopping liquid flow to or from a peritoneal cavity of the patient, said liquid occluder being connected to said fluid distribution system and operated thereby;

and a valve in said fluid distribution system for allowing air flow from the occluder to render the occluder operative when the system is disabled to prevent liquid flow.

6. A liquid pumping system, comprising:

a) a first liquid pump having a diaphragm;

b) a second liquid pump having a diaphragm;

c) a fluid distribution system for driving each liquid pump, having

(i) selector valve means,

(ii) flow proportional means,

(iii) conduit means between the selector valve means and the flow proportional means and the first and second liquid pumps;

d) a source of positive pressure fluid for expelling liquid from each liquid pump; and

e) a source of vacuum fluid for drawing liquid into each liquid pump.

7. A liquid pumping system according to claim 6 further comprising a plurality of liquid valves in communication with the first and second liquid pumps and a plurality of actuator valves for receiving positive pressure fluid and vacuum fluid from the sources of positive pressure fluid and vacuum fluid for liquid valves connected to and operated by the fluid distribution system.

8. A liquid pumping system, comprising:

a pump having a diaphragm defining a liquid chamber;

a liquid input conduit for transporting liquid to the liquid chamber of the pump;

a liquid output conduit for transporting liquid from the liquid chamber of the pump;

a positive pressure fluid source for supplying fluid at a pressure greater than atmospheric pressure to the diaphragm of the pump to drive the diaphragm to expel liquid from the liquid chamber;

a negative pressure fluid source for supplying fluid at a pressure less than atmospheric pressure to the diaphragm of the pump to drive the diaphragm to draw liquid into the liquid chamber; and

pressure regulating means operatively connected to the positive and negative pressure fluid sources for regulating the flows of positive pressure fluid and negative pressure fluid to the diaphragm of the pump to provide a pressure regulated drive of the diaphragm.

9. A liquid pumping system according to claim 8 wherein the pressure regulating means comprises:

a first control valve between the positive pressure fluid source and the diaphragm; and

a second control valve between the negative pressure fluid source and the diaphragm;

wherein each of said first and second control valves can be opened to varying amounts to regulate fluid flow between the fluid sources and the diaphragm.

10. A liquid pumping system according to claim 9, wherein the positive pressure fluid source comprises a first compressor connected directly to the diaphragm without a reservoir therebetween;

and

wherein the negative pressure fluid source comprises a second compressor connected directly to the fluid chamber without a reservoir therebetween.

11. A liquid pumping system according to claim 9, wherein the positive pressure control valve and the negative pressure control valve are each opened varying amounts at the same time to regulate fluid flow to and from the diaphragm.

12. A liquid pumping system according to claim 9, further comprising a pressure sensor for sensing the pressure being supplied at the diaphragm.

13. A liquid pumping system according to claim 9, wherein a pressure regulating circuit closes the negative pressure flow control valve when the positive pressure flow control valve is opened and closes the positive pressure flow control valve when the negative pressure control valve is opened.

14. A liquid pumping system according to claim 8, further comprising:

a first liquid valve in the liquid input conduit leading into the liquid chamber, and

a second liquid valve in the liquid output conduit leading away from the liquid chamber.

15. A liquid pumping system according to claim 9, wherein

the first and second liquid valves each have a valve diaphragm and a liquid chamber, the valve chambers being separated by the valve diaphragm, the aforementioned elements operating in cooperation to control liquid flow through each valve;

and

further comprising a plurality of fluid conduits extending from the positive pressure fluid source and the negative pressure fluid source to the fluid chambers of the respective valves.

16. A liquid pumping system according to claim 15, further comprising a check valve positioned in the conduit between the positive pressure source and the liquid control valves to prevent positive pressure fluid from moving back into the positive pressure fluid source.

17. A liquid pumping system according to claim 15, wherein each of the liquid flow control valves comprises a raised valve seat which cooperates when engaged by the valve diaphragm stops liquid flow therethrough and which when displaced from the valve seat allows liquid to flow between the valve seat and the diaphragm.

18. A liquid pumping system according to claim 15 wherein each liquid flow control valve is actuated by air controlled by a three-way valve, the three-way valve communicating either positive pressure air or negative pressure air to the fluid valve chamber in order to seat or unseat the valve diaphragm, respectively.

19. A peritoneal dialysis system, comprising:

a pair of diaphragm pumps, each diaphragm pump of the pair of diaphragm pumps having a diaphragm defining a liquid chamber, each liquid chamber having an inlet and an outlet;

a plurality of liquid conduits, each liquid conduit of the plurality being operatively connected to at least one of the diaphragm pumps for providing a liquid input to or a liquid output from the liquid chamber of the respective diaphragm pump;

a positive pressure fluid source for supplying fluid at a first pressure greater than atmospheric pressure to the fluid chamber of the pump to drive the diaphragm to expel liquid from the liquid chamber of the pump;

a negative pressure fluid source for supplying fluid at a second pressure less than atmospheric pressure to the fluid chamber of the pump to drive the diaphragm to draw liquid into the liquid chamber of the pump;

pressure regulating means for regulating fluid flow between the fluid sources and the fluid chambers of the pumps;

a plurality of liquid valves, each liquid valve being associated with one or more of the liquid conduits, whereby actuation of a selected liquid valve will permit liquid to flow through the liquid valve; and

selector/actuator means for each liquid valve for selecting either positive pressure fluid or negative pressure fluid for actuation of each liquid valve.

20. An actuator system for actuating of a plurality of liquid valves and at least two liquid pumps, each liquid pump having a diaphragm defining a liquid chamber, comprising:

a positive pressure fluid source;

a negative pressure fluid source;

a pair of variable pressure fluidic actuators for each liquid pump, each actuator including a first control valve between the positive pressure fluid source and the diaphragm, and a second control valve between the negative pressure fluid source and the diaphragm, wherein each of said first and second control valves can be opened to varying amounts to regulate fluid flow between the fluid sources and the diaphragm; and

selector/actuator means for each liquid valve for selecting either positive pressure fluid or negative pressure fluid for actuation of the liquid valve.

21. An actuator system for fluidic actuation of a plurality of liquid valves and at least two liquid pumps, each liquid pump having a diaphragm defining a driven liquid chamber and a driving fluid chamber, comprising:

a positive pressure fluid source;

a negative pressure fluid source;

a fluid distribution network for distributing fluid between the fluid sources and the fluidic actuators;

a variable pressure fluidic actuator for each liquid pump, including a selector valve for selecting from either the positive pressure fluid source or the negative pressure fluid source and a control valve between the selected fluid source and the fluid chamber, wherein said control valve can be opened to varying amounts to regulate fluid flow between the fluid source and the fluid chamber; and

selector/actuator means for each liquid valve for selecting either positive pressure fluid or negative pressure fluid for actuation of the liquid valve.

22. An automated peritoneal dialysis system for supplying dialysate to a peritoneal cavity of a patient, comprising:

a controller for generating a valve control signal in response to a command signal and to a pressure feedback signal;

a pneumatic pressure distribution system for control by the controller and having a flow adjustable valve for supplying air to an air delivery channel in response to the valve control signal, said pneumatic pressure distribution system having a pressure sensor for producing the pressure signal in response to the pressure of the air supplied by the flow adjustable valve;

a pressure signal feedback channel coupling the pressure signal to the controller; and

a cassette interface for receiving a dialysate handling disposable cassette of a disposable liquid delivery set, said cassette interface having a diaphragm pump station connected to the flow adjustable valve for receiving air therefrom, the received air being for supply to a diaphragm of a diaphragm pump of the disposable cassette for driving the diaphragm pump to pump dialysate through other portions of the disposable liquid delivery set for delivery to a peritoneal cavity of a patient.

23. A dialysate delivery system, comprising:

a dialysate cassette interface for pneumatic coupling to a disposable dialysate cassette having a plurality of pneumatically controlled dialysate valves and a dialysate diaphragm pump, the dialysate cassette interface having a plurality of pneumatically driven cassette valve actuators for coupling with respective ones of the pneumatically controlled cassette dialysate valves and a diaphragm pump drive station for coupling to the dialysate diaphragm of the dialysate cassette;

a controller for generating a plurality of pneumatic valve control signals and for generating a diaphragm pump pressure control signal responsive to a received pressure signal;

a plurality of on-off valves responsive to the pneumatic valve control signals to provide selected pneumatic control forces to the pneumatically driven cassette valve actuators of the cassette interface;

an adjustable pneumatic valve responsive to the pressure control signal to throttle a pneumatic source, resulting in a pneumatic feed to the diaphragm pump drive station of the cassette interface; and

a pressure transducer for producing a pressure signal in response to the pneumatic feed.