Osmotic device for delayed delivery of agent

• US 5,938,654 A
• Filed: 02/01/1995
• Issued: 08/17/1999
• Est. Priority Date: 06/25/1987
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Larsen, Steven D., Wong, Patrick S.-L., Eckenhoff, James B., Theeuwes, Felix, Huynh, Hoa T.
• Primary Examiner(s): Bockelman, Mark
• Application Number:
  US08/382,947
• Time in Patent Office: 1,658 Days
• Field of Search: 604/890.1, 604/892.1, 604/891.1, 604/93, 604/131, 424/473, 424/452, 424/453, 424/472, 424/438, 220/306, 220/352
• US Class Current: 604/892.1
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61K 9/4808 characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release capsules filled with granules or microparticles A61K9/16; filled with microcapsules or coated microparticles A61K9/50; with mixture of different granules, microcapsules, (coated) microparticles A61K9/5084

Abstract

A dispenser for use in a fluid environment of use which is capable of the delivery of one or a plurality of discrete active agent-containing units in any desired delivery pattern or profile. It also can provide for the initially delayed delivery of an active agent to the environment of use and for high accuracy in the timing of delivery of the active agent.

Claims

1. A dispensing device for dispensing an active agent to a fluid environment of use, the dispensing device comprising:

(a) a housing and a container in sliding telescoping relation with each other, the housing comprising an open end and a fluid-passing portion opposite the open end, said fluid-passing portion permitting passage of fluid into the housing, and the container comprising an open end, wherein said container open end is disposed within said housing open end to form a closed unit;

(b) an active agent formulation comprising an active agent within said container;

(c) a fluid-activating driving member within said housing, in fluid-transmitting relationship with the fluid-passing portion of the housing, said fluid-activated driving member expanding as it imbibes fluid thereby effecting separation of the housing and container of the closed unit, for providing a sharp pulsed release of the active agent formulation to the fluid environment of use; and

(d) optionally, a partition layer between the driving member and the container open end.

2. A dispensing device according to claim 1 wherein the container is comprised of a substantially fluid impermeable composition.

3. A dispensing device according to claim 1 wherein the active agent formulation comprises a plurality of dosage forms.

4. A dispensing device according to claim 3 wherein the plurality of dosage forms contain the same active agent.

5. A dispensing device according to claim 3 wherein the plurality of dosage forms contain different active agents.

6. A dispensing device according to claim 1 wherein the active agent is selected from the group consisting of proteins and peptides.

7. A dispensing device according to claim 1 wherein the active agent is calcitonin.

8. A dispensing device according to claim 1 which further comprises an enteric coating.

9. A dispensing device according to claim 1 wherein the container comprises two or more longitudinal portions.

10. A dispensing device according to claim 9 wherein the longitudinal portions comprise interlocking junctions.