Solid active extrusion compound preparations containing low-substituted hydroxypropylcellulose

• US 5,939,099 A
• Filed: 07/30/1997
• Issued: 08/17/1999
• Est. Priority Date: 02/14/1995
• Status: Expired due to Term

• Current Assignee: Abbvie Deutschland GmbH & Company KG (Abbvie Incorporated)
• Original Assignee: BASF AG (BASF SE)
• Inventors: Breitenbach, Jorg, Sanner, Axel, Rosenberg, Joerg, Grabowski, Sven
• Primary Examiner(s): Webman, Edward J.
• Application Number:
  US08/875,514
• Time in Patent Office: 748 Days
• Field of Search: 424/484, 424/488, 424/499, 424/468, 424/457, 264/464, 264/46.1
• US Class Current: 424/488
• CPC Class Codes: A61K 9/2054 Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
• CPC Class Codes: A61K 9/2095 Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing mechanical aspects A61J3/00

Abstract

Solid preparations are obtainable by melt extrusion of

A) at least one active compound,

B) a mixture of

B1) from 10 to 90% by weight of a water-soluble, thermoplastic polymer, and

B2) from 10 to 90% by weight of a low-substituted hydroxypropylcellulose, and

C) from 0 to 50% by weight, based on the total amount of the preparation, of customary pharmaceutical auxiliaries.

Claims

1. A solid pharmaceutical composition obtained by joint melt extrusion of

A) one or more active compounds, and

B) a mixture of

B1) from 10 to 90% by weight of a water-soluble hydroxypropylcellulose, and

B2) from 10 to 90% by weight of a low-substituted water-insoluble hydroxypropylcellulose, and

C) from 0 to 50% by weight, based on the total amount of the preparation of one or more pharmaceutical auxiliaries.

2. A process for producing the composition defined in claim 1, which process comprises processing the active compound component A) with the polymeric component B) and the auxiliaries C) to give a melt, extruding the melt and shaping the extruded melt.