Methods of administering BMP-5 compositions

• US 5,939,388 A
• Filed: 01/23/1997
• Issued: 08/17/1999
• Est. Priority Date: 07/01/1986
• Status: Expired due to Fees

• Current Assignee: Genetics Institute LLC (Pfizer Inc.)
• Original Assignee: Elizabeth A. Wang, John M. Wozney, Vicki A. Rosen
• Inventors: Wang, Elizabeth A., Rosen, Vicki A., Wozney, John M.
• Primary Examiner(s): Kemmerer, Elizabeth
• Application Number:
  US08/788,729
• Time in Patent Office: 936 Days
• Field of Search: 514/2, 514/12, 424/85.1
• US Class Current: 514/8.8
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61L 24/043 Mixtures of macromolecular materials
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 2430/06 for cartilage reconstruction, e.g. meniscus
• CPC Class Codes: A61L 27/227 Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
• CPC Class Codes: C07K 14/51 Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
• CPC Class Codes: C08L 89/00 Compositions of proteins; Compositions of derivatives thereof foodstuff preparations A23J3/00
• CPC Class Codes: C12N 15/85 for animal cells
• CPC Class Codes: C12N 2800/108 episomal vectors
• CPC Class Codes: C12N 2840/20 translation of more than one cistron

Abstract

Purified BMP-5 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.

Claims

1. A method for inducing bone and/or cartilage formation in a patient in need thereof comprising administering to said patient an effective amount of a composition comprising a matrix, a pharmaceutically acceptable vehicle, and a protein selected from the group consisting of:

(a) a purified dimeric BMP-5 protein comprising the amino acid sequence from amino acid #1 or 28 or 317 (Ala) or 328 to amino acid #454 (His) as shown in Table III; and

(b) naturally occurring allelic sequences thereof.

2. The method of claim 1 wherein the protein is encoded by the BMP-5 DNA sequence of ATCC 68019.