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Crystalline FRAP complex

  • US 5,939,528 A
  • Filed: 10/31/1997
  • Issued: 08/17/1999
  • Est. Priority Date: 10/23/1996
  • Status: Expired due to Term
First Claim
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1. An orthorhombic crystalline composition in the space group P21 21 21 which diffracts X-rays at a resolution of 2.7 Å

  • or better, each asymmetric unit of which containing one complex comprising;

    (a) a first protein comprising a peptide sequence derived or selected from the peptide sequence of human FK506 binding protein 12 (FKBP12),(b) a second protein comprising a peptide sequence derived or selected from the peptide sequence of an FKBP;

    rapamycin binding domain of human FKBP;

    Rapamycin Associated Protein (FRAP), and(c) rapamycin or a rapamycin derivative capable of forming a ternary complex with the first and second proteins.

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