Apparatus for tissue type recognition within a body canal

• US 5,941,822 A
• Filed: 03/17/1997
• Issued: 08/24/1999
• Est. Priority Date: 03/17/1997
• Status: Expired due to Fees

• Current Assignee: Polartechnics Ltd.
• Original Assignee: Polartechnics Ltd.
• Inventors: Bull, David J., Wunderman, Irwin, Skladnev, Victor N., Thompson, Richard L.
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): SHAW, SHAWNA JEANNINE
• Application Number:
  US08/818,930
• Time in Patent Office: 890 Days
• Field of Search: 128/664, 128/665, 128/633, 128/634, 600/473, 600/476, 600/310, 600/342, 600/372, 600/373, 600/178, 600/407, 600/475, 600/477
• US Class Current: 600/407
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/4331 of the cervix A61B5/435 takes precedence

Abstract

A method and apparatus for tissue type recognition for use within the narrow confines of body canals and which can quickly produce an objective identification of the tissue types including the presence of pre-cancerous and cancerous activity. Possible configurations for the probe include endocervical probe configurations which make measurements in directions orthogonal to the long axis of the probe and configurations where multiple probe "tips" are arranged in a "wood drill" configuration. The apparatus has a measurement section that has at least one source of electromagnetic radiation such as a light emitting diode, a barrier which acts to confine the direction that the radiation can take and a detector such as a photodiode beyond the barrier, which is able to detect the radiation after it has been backscattered from tissue in close proximity to the surface of the cylinder. In the vicinity of these components one or more electrodes may also be positioned on the surface of the cylinder such that they are able to contact the tissue under examination thereby enabling simultaneous electrical property measurements to be made. The radiation source and the electrodes receive electrical signals produced by a programmed controller. The radiation detector and the electrode signals are processed by the controller. Comparator means in the controller are used to compare the signals with known values to thereby identify the tissue type.

Claims

1. Apparatus for identifying tissue within a body canal which is suspected of being physiologically changed as a result of pre-cancerous or cancerous activity, said apparatus comprising

a plurality of optical and electrode systems, each such system comprising

a light emitting die emitting light in response to a drive signal and configured to irradiate said tissue;

a detector die configured to receive that radiation after it has been backscattered by said tissue and to provide a responding signal;

a barrier sited between the two dice to provide optical and electrical isolation between the two;

an electrode configured to supply electrical signals to said tissue and to measure the response of the tissue;

the components above being configured in a probe of circular or similar cross section small enough to enter the said canal;

a controller coupled to the emitters, the detectors and the electrodes that supplies the necessary drive signals and receives the responses, said controller comprising

a processor to categorize said tissue, and

a comparator for comparing the categorization of said tissue with expected tissue types from a catalogue so as to identify said tissue, and

an indicator arrangement for indicating to a user the tissue type identified.

2. Apparatus as claimed in claim 1 wherein said configurations of opto-electronics and electrodes are situated on more than one face of the probe.

3. Apparatus as claimed in claim 1 wherein said configurations of opto-electronics and electrodes are situated on a cone-shaped probe.

4. Apparatus as claimed in claim 1 in which the wiring from the detectors is shielded electrically by mounting conductive metal surfaces in close proximity to the said wiring to reduce the capacitive coupling of that wiring to the circuit that feeds current to the light emitters in the probe tip and to reduce the capacitive coupling to the patient who is being examined, thereby reducing the amount of cross coupling and electrical interference added to the detector signal.

5. An apparatus as claimed in claim 1 in which a current is applied to LEDs and the voltage drop is measured to determine the temperature of the LEDs to enable calculation of a correction for the radiation output from the LEDs in order to apply an adjustment to the measured values of the detector signal.

6. Apparatus as claimed in claim 2 in which the wiring from the detectors is shielded electrically by mounting conductive metal surfaces in close proximity to the said wiring to reduce the capacitive coupling of that wiring to the circuit that feeds current to the light emitters in the probe tip and to reduce the capacitive coupling to the patient who is being examined, thereby reducing the amount of cross coupling and electrical interference added to the detector signal.

7. Apparatus as claimed in claim 3 in which the wiring from the detectors is shielded electrically by mounting conductive metal surfaces in close proximity to the said wiring to reduce the capacitive coupling of that wiring to the circuit that feeds current to the light emitters in the probe tip and to reduce the capacitive coupling to the patient who is being examined, thereby reducing the amount of cross coupling and electrical interference added to the detector signal.