Method and device for controlling mammalian reproductive cycle
First Claim
1. A method of inducing ovulation in a female mammal having seasonal estrous and anestrous periods, comprising administering an agent selected from the group consisting of LHRH, prodrugs of LHRH, analogs of LHRH, salts thereof and mixtures thereof, to the mammal during a seasonal anestrous period by electrotransport through a body surface of the mammal over a period of time effective to, and in an amount sufficient to, induce ovulation in the mammal.
0 Assignments
0 Petitions
Accused Products
Abstract
A method encompasses the substantially continuous electrotransport delivery of luteinizing hormone releasing hormone (LHRH), prologues, analogues, salts or mixtures thereof, preferably at a substantially constant rate, to a female mammal for the purpose of modifying its reproductive cycle. An electrotransport device substantially is suited for the continuous delivery of LHRH prologues, analogues, salts or mixtures thereof over an extended period of time to a mammal. The present technology may be successfully applied to the controlled breeding of mammals, such as thoroughbred race horses.
-
Citations
19 Claims
- 1. A method of inducing ovulation in a female mammal having seasonal estrous and anestrous periods, comprising administering an agent selected from the group consisting of LHRH, prodrugs of LHRH, analogs of LHRH, salts thereof and mixtures thereof, to the mammal during a seasonal anestrous period by electrotransport through a body surface of the mammal over a period of time effective to, and in an amount sufficient to, induce ovulation in the mammal.
- 5. A method of inducing ovulation in a female mammal having seasonal estrous and anestrous periods, comprising administering an agent selected from the group consisting of LHRH, prodrugs of LHRH, analogs of LHRH, salts thereof and mixtures thereof, to the mammal during a seasonal estrous period by electrotransport through a body surface of the mammal over a period of time effective to, and in an amount sufficient to, restart the estrous cycle of the mammal.
Specification