Passive drug delivery apparatus

• US 5,941,848 A
• Filed: 11/14/1996
• Issued: 08/24/1999
• Est. Priority Date: 11/14/1996
• Status: Expired due to Fees

• Current Assignee: Baxter International Inc., Kanae Co., Ltd.
• Original Assignee: Baxter International Inc.
• Inventors: Nishimoto, Fumiaki, Fowles, Thomas A., Maeda, Kazumasa, Kazama, Haruki
• Primary Examiner(s): Yasko, John D.
• Assistant Examiner(s): MENDEZ, MANUEL A
• Application Number:
  US08/746,696
• Time in Patent Office: 1,013 Days
• Field of Search: 604/82, 604/83, 604/85, 604/86, 604/56, 604/411-414
• US Class Current: 604/82
• CPC Class Codes: A61M 2005/1623 Details of air intake
• CPC Class Codes: A61M 5/1409 in series, e.g. first substance passing through container holding second substance, e.g. reconstitution systems needle sets A61M5/162

Abstract

The present invention provides an apparatus for introducing a reconstituted drug in a drug vial into a medical liquid while venting any gas within the vial to the atmosphere. The assembly includes a receptacle disposed in the middle of a fluid conduit for the medical fluid and which has an upper chamber and lower chamber. The assembly also has a cannula assembly which mounts upon and pierces a septum of the receptacle and also a pierceable stopper of the drug vial. The cannula assembly includes a pair of coaxial cannulas which pierce the stopper of the drug vial and establish a first flow path from the upper chamber to the drug vial and a second flow path from the drug vial to the lower chamber. The cannula assemble also includes a cannula that forms a vent passage in fluid communication with an upper portion of the vial, upon the piercing of the drug vial, with an end of the vent passage communicating with the atmosphere.

Claims

1. An apparatus for the delivery of a passively reconstituted beneficial agent contained in a vial into a medical liquid, comprising:

first flow path adapted to introduce into the vial the medical liquid from a fluid conduit, the first flow path including an upper chamber of a receptacle disposed in the fluid conduit and an annular space coaxially extending from the upper chamber to an upper part of the vial at around a lower cannula hollow tube which is formed at the lower part of a cannula assembly along the central axis thereof, the cannula assembly extending from the bottom of the vial to a lower chamber of the receptacle when the cannula assembly has piercingly and sealingly been mounted on the receptacle for use;

second flow path adapted to deliver the mixed solution containing the medical liquid and agent from the vial into the fluid conduit, the second flow path including the lower cannula hollow tube extending from an upper part of the vial to the receptacle lower chamber and the lower chamber; and

vent passage means for the communication of the vial with the atmosphere, the vent passage including an upper cannula hollow tube which is formed at an upper part of the cannula assembly along the central axis thereof, and which extends from the bottom of the vial to the lower cannula hollow tube, a side cannula tube extending parallel to the lower hollow tube from an end part of the upper cannula hollow tube to a small chamber, which has a vent hole to the atmosphere, and which is intermittently disposed between the vial and the upper chamber, a hollow tube connecting the upper hollow tube and the side hollow tube, and the small chamber.

2. The apparatus of claim 1, wherein both a medical liquid inlet provided at an end part of the annual space extending coaxially from the upper chamber to the upper part of the vial and a mixed outlet provided at an end part of the lower cannula hollow tube extending from the upper part of the vial to the lower chamber are set apart by separate notches provided for their respective flow paths.

3. An apparatus for the delivery of a passively reconstituted beneficial agent contained in a vial into a medical liquid, comprising:

first flow path adapted to introduce into the vial the medical liquid from a fluid conduit, the first flow path including an upper chamber of a receptacle disposed in the fluid conduit and a first toothlike space, which extends around a cannula hollow tube of a cannula assembly from the upper chamber to an upper part of the vial, and which is formed at a central part of the cannula assembly extending from the bottom of the vial to a lower chamber of the receptacle when the cannula assembly has piercingly and sealingly been mounted on the receptacle for use;

second flow path adapted to deliver the mixed solution containing the medical liquid and agent from the vial into the fluid conduit, the second flow path comprises a second space formed around the hollow tube at a central part of the cannula assembly extending from the bottom of the vial to a lower chamber of the receptacle and the lower chamber; and

vent passage means for the communication of the vial with the atmosphere, the vent passage means including the cannula hollow tube extending from the bottom of the vial to a small chamber, which is disposed within the lower chamber, and has a vent hole to atmosphere.

4. An apparatus for the delivery of a passively reconstituted beneficial agent contained in a vial into a medical liquid, comprising:

first flow path adapted to introduce into the vial the medical liquid from a fluid conduit, the first flow path including a front chamber of a receptacle disposed in the fluid conduit and a first toothlike space, which extends around a cannula hollow tube of a cannula assembly from the front chamber to an upper part of the vial;

second flow path adapted to deliver the mixed solution containing the medical liquid and agent from the vial into the fluid conduit, the second flow path including the cannula hollow tube extending from the bottom of the vial to a rear chamber of the receptacle and the rear chamber; and

vent passage means for the communication of the vial with the atmosphere, the vent passage means including the second toothlike space, which extends from an upper part of the vial to a small chamber disposed intermediately between the vial and the front chamber, and which is formed around the hollow tube at a central part of the cannula assembly and the small chamber.