Vaso-occlusive member assembly with multiple detaching points

• US 5,941,888 A
• Filed: 02/18/1998
• Issued: 08/24/1999
• Est. Priority Date: 02/18/1998
• Status: Expired due to Term

• Current Assignee: Stryker European Operations Holdings, LLC (Stryker Corporation)
• Original Assignee: Target Therapeutics, Inc. (Boston Scientific Corporation)
• Inventors: Wallace, Michael P., Roue, Chad C.
• Primary Examiner(s): ROBERT, EDUARDO C
• Assistant Examiner(s): ROBERT, EDUARDO C
• Application Number:
  US09/025,707
• Time in Patent Office: 552 Days
• Field of Search: 606/32, 606/41, 606/49, 606/28, 606/108, 606/191, 606/200
• US Class Current: 606/108
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12113 within an aneurysm
• CPC Class Codes: A61B 17/1214 Coils or wires
• CPC Class Codes: A61B 17/12163 having a string of elements connected to each other
• CPC Class Codes: A61B 2017/1205 Introduction devices
• CPC Class Codes: A61B 2017/12063 electrolytically detachable

Abstract

This device is an apparatus for endovascular occlusion through the formation of thrombi in arteries, veins, aneurysms, vascular malformations, and arteriovenous fistulas. In particular, the device includes multiple vaso-occlusive members connected by electrolytically disintegratible links. Each link connects to the vaso-occlusive member by electrically insulative and conductive joints on opposite ends of the link. The vaso-occlusive members are delivered through a delivery catheter having on its distal end an electrode for electrical contact with the vaso-occlusive member. Upon application of an electrical current through electrode to the vaso-occlusive member and its conductive joint to electrolytically disintegratible link, the link disintegrates, selectively detaching the desired number of vaso-occlusive members into the target thrombus formation site.

Claims

1. An assembly for use in the formation of an occlusion comprising:

a vaso-occlusive member having a proximal end and a distal end,

an electrically insulative joint located proximally on said vaso-occlusive member,

an electrolytically disintegratible link located proximally of said electrically insulative joint, and

an electrically conductive joint located proximally on said electrolytically disintegratible link and distally on an additional vaso-occlusive member.

2. The assembly of claim 1 where at least one of said vaso-occlusive members is a coil.

3. The assembly of claim 1 where the electrically insulative joint comprises an electrically insulative biocompatible adhesive.

4. The assembly of claim 1 where the electrically insulative joint comprises an biocompatible oxide of a biocompatible metal.

5. The assembly of claim 4 where the biocompatible metal is tantalum.

6. The assembly of claim 1 where the electrically insulative joint comprises at least one polymer.

7. The assembly of claim 6 where the polymer is selected from the group consisting of polyfluorocarbons, polyxylylene, polyethylene, polyethylene terepthalate, polypropylene, polyurethane, polyimides, and silicone polymers.

8. The assembly of claim 6 where the electrically insulative joint additionally comprises an electrically insulative biocompatible adhesive.

9. The assembly of claim 6 where the electrically insulative joint additionally comprises a biocompatible oxide of a biocompatible metal.

10. The assembly of claim 9 where the biocompatible metal is tantalum.

11. The assembly of claim 1 where the electrically conductive end of the link comprises a hypotube.

12. An assembly for use in the formation of a vascular occlusion comprising:

a proximal section comprising a core wire having a proximal end and a distal end, a first electrically insulative joint attached to the distal end of said core wire, and a first vaso-occlusive member attached to said first electrically insulative joint,

one or more distal sections, each comprising an electrically conductive joint attached to a distal electrolytically disintegratible link, an additional electrically insulative joint located distally on said electrically disintegratible link, and an additional distal vaso-occlusive member, and

a catheter having a proximal end and a distal end and having an electrode configured for electrical contact with one of said vaso-occlusive members,

whereby upon application of electrical current to a distal section, one of said electrolytically disintegratible links disintegrates, releasing a portion of said assembly.

13. The assembly of claim 12 where at least one of said vaso-occlusive members is a coil.

14. The assembly of claim 12 where the electrically insulative joint comprises an electrically insulative biocompatible adhesive.

15. The assembly of claim 12 where the electrically insulative joint comprises an electrically insulative oxide of a biocompatible metal.

16. The assembly of claim 15 where the biocompatible metal is tantalum.

17. The assembly of claim 12 where the electrically insulative joint comprises at least one polymer.

18. The assembly of claim 17 where the polymers are selected from the group consisting of polyfluorocarbons, polyxylylene, polyethylene, polyethylene terepthalate, polypropylene, polyurethane, polyimides, and silicone polymers.

19. The assembly of claim 17 where the electrically insulative joint comprises an electrically insulative biocompatible adhesive.

20. The assembly of claim 17 where the electrically insulative joint additionally comprises an electrically insulative oxide of a biocompatible metal.

21. The assembly of claim 17 where the biocompatible metal is tantalum.

22. The assembly of claim 12 where the electrically conductive insulative joint comprises a hypotube.

23. The assembly of claim 12 where said catheter additionally comprises at least two radiopaque markers.

24. The assembly of claim 23 where the distance between at least two of said radiopaque markers substantially equals the distance between said electrolytically disintegratible link and a second electrolytically disintegratible link.

25. The assembly of claim 12 where an electrically conductive extension of the electrode extends radially towards the center of the catheter and is in electrical contact with the vaso-occlusive member.

26. The assembly of claim 25 where the electrode extension is configured to allow passage of the vaso-occlusive member through the catheter in a direction from the proximal end towards the distal end and to simultaneously hinder passage of the vaso-occlusive member through the catheter in the opposite direction while maintaining the electrical contact with the vaso-occlusive member.

27. An assembly for use in the formation of a vascular occlusion, comprising:

a proximal section comprising a core wire having a proximal end and a distal end, a first electrically insulative joint attached to the distal end of said core wire, and a first vaso-occlusive member attached to said first electrically insulative joint,

one or more distal sections, each comprising an electrically conductive joint attached to a distal electrolytically disintegratible link, an additional electrically insulative joint located distally on said electrically disintegratible link, and an additional distal vaso-occlusive member,

a first catheter for delivering said proximal and distal sections to a desired vascular occlusion site, and

a second catheter having an electrode configured for electrical contact with one of said vaso-occlusive members,

whereby upon application of electrical current to said assembly, one of said electrolytically disintegratible links disintegrates, releasing a portion of said assembly.

28. The assembly of claim 27 where at least one of said vaso-occlusive members is a coil.

29. The assembly of claim 27 where the electrically insulative joint comprises an electrically insulative biocompatible adhesive.

30. The assembly of claim 27 where the electrically insulative joint comprises an oxide of a biocompatible metal.

31. The assembly of claim 30 where the biocompatible metal is tantalum.

32. The assembly of claim 27 where the electrically insulative joint comprises at least one polymer.

33. The assembly of claim 32 where the polymers are selected from the group consisting of polyfluorocarbons, polyxylylene, polyethylene, polyethylene terepthalate, polypropylene, polyurethane, polyimides, and silicone polymers.

34. The assembly of claim 32 where the electrically insulative joint comprises an electrically insulative biocompatible adhesive.

35. The assembly of claim 32 where the electrically insulative joint additionally comprises an electrically insulative oxide of a biocompatible metal.

36. The assembly of claim 32 where the biocompatible metal is tantalum.

37. The assembly of claim 27 where the electrically conductive insulative joint comprises a hypotube.