Method of local radiotherapy by polymerizing a material in vivo to form a hydrogel

• US 5,942,209 A
• Filed: 11/03/1997
• Issued: 08/24/1999
• Est. Priority Date: 03/11/1996
• Status: Expired due to Fees

• Current Assignee: Genzyme Corporation (Sanofi )
• Original Assignee: Focal PLLC
• Inventors: Avila, Luis Z., Leavitt, Richard D.
• Primary Examiner(s): Dees, Jose' G.
• Assistant Examiner(s): Hartley, Michael G.
• Application Number:
  US08/963,639
• Time in Patent Office: 659 Days
• Field of Search: 424/1.25, 424/1.29, 424/1.33, 424/1.21, 424/1.37, 600/1, 600/3, 600/4, 600/7, 600/8, 623/1
• US Class Current: 424/1.25
• CPC Class Codes: A61K 51/0497 conjugates with a carrier being an organic compounds
• CPC Class Codes: A61K 51/06 Macromolecular compounds , carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules peptides, proteins, polyamino acids A61K51/08; antibodies A61K51/10
• CPC Class Codes: A61K 51/1213 Semi-solid forms, gels, hydrogels, ointments, fats and waxes that are solid at room temperature
• CPC Class Codes: A61P 35/00 Antineoplastic agents

Abstract

Locally deposited polymer depots are used as a vehicle for the immobilization and local delivery of a radionuclide or radiopharmaceutical. Radionuclides are incorporated in their elemental forms, as inorganic compounds, or are attached to a larger molecule or incorporated into the polymer, by physical or chemical methods. Ancillary structure may be employed to control the rate of release. Standard radionuclides which have been used for local radiotherapy may be used, such as radionuclides of iodine, iridium, radium, cesium, yttrium or other elements.

Claims

1. A method for local radiotherapy at a site in a patient, comprising forming a polymeric depot at a site at which therapy is to be administered by combining one or more radioisotopes with a material capable of polymerizing in vivo to form a biodegradable biocompatible polymeric material;

administering the combination to a site in a patient to which radiotherapy is to be administered; and

polymerizing the polymerizable material at the site to form a biodegradable, biocompatible polymeric hydrogel,

wherein the material includes a functional group selected from the group consisting of epoxy, urethane, ester, amide, sulfone, and ethylenically unsaturated groups.

2. The method of claim 1 wherein the polymerizable material is a polymer containing polymerizable groups applied in a first fluent state and converted to a second less fluent state upon application to tissue and subsequent polymerization.

3. The method of claim 1 wherein the polymerizable material is chemically coupled to the radioisotopes.

4. The method of claim 1 wherein the polymerizable material is conjugated to the radioisotopes via a chelating agent coupled to the material.

5. The method of claim 1 wherein the depot comprises microspheres comprising radioisotopes.

6. The method of claim 5 wherein the microspheres are biodegradable at a different rate than the depot.

7. The method of claim 1, wherein the material capable of polymerizing includes degradable linkages selected from the group consisting of ester, orthocarbonate, carbonate, anhydride, amide, peptide, acetal, phosphazene and Schiff base linkages.

8. The method of claim 1, wherein the functional group is an ethylenically unsaturated group.